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Integrally Joined Stainless Steel-NiTi Medical Devices
TS-050057 — A method for manufacturing surgical tools and implants with strong, gapless joints between NiTi (Nitinol) and stainless steel to capitalize on the best properties of both materials.
NiTi (Nitinol) is widely accepted and used for medical devices such as surgical tools and implants due to its biocompatibility and unique thermal-mechanical properties which provide superelastic or shape memory responses. However, there are currently no commercial solutions for joining of NiTi to …
  • College: College of Engineering (COE)
  • Inventors: Panton, Boyd; Dapino, Marcelo; Gingerich, Mark; Headings, Leon; Morris, Jennifer
  • Licensing Officer: Zinn, Ryan

Automotive Security Assurance Testbed
TS-050056 — This testbed serves as a virtual way to increase security assurance in the automotive design phase. With connectivity becoming such a prominent aspect of automotive design security risks can also risk safety. The goal is to be able to provide a stronger assurance of security in modern vehicles.
The days where vehicles functioned in isloation are soon behind us. Push from consumers as well as the government has brought an age in which automobiles now function as complex systems of communication networks and sensors. As communication pathways within vehicles increase, the safety of their p…
  • College: College of Engineering (COE)
  • Inventors: Appel, Matthew; Ahmed, Qadeer; Oruganti, Pradeep Sharma
  • Licensing Officer: Hong, Dongsung

Physics Model-Based Attack Filter for a Controller Area Network (CAN)
TS-050050 — A method for filtering malicious messages on a CAN Network. This method is a physics, model, based method that utilizes knowledge of the CAN network as well as the physics of the systems being controlled to remove malicious messages from effecting the intended function of the controls algorithms on vehicles.
There has been a rapid increase in the number of embedded controllers used onboard vehicles. Connectivity and automation promise better safety, efficiency, and comfort. Vehicles in the future will be connected to more than just our personal devices, but to other vehicles and public infrastructure …
  • College: College of Engineering (COE)
  • Inventors: Appel, Matthew; Ahmed, Qadeer; Oruganti, Pradeep Sharma
  • Licensing Officer: Hong, Dongsung

Method for diagnosis and prognosis of Alzheimer's disease
TS-050046 — Methods using miRNAs for early Alzheimer’s Disease diagnoses and altered expression of key autophagy related proteins
The Need Alzheimer’s Disease (AD) is the most common cause of age-related dementia leading to severe and irreversible neurodegeneration and cognitive decline. Currently, AD has no cure or effective preventive approaches. Using current diagnostic techniques, AD cannot be clinically diagnosed b…
  • College: College of Medicine (COM)
  • Inventors: Amer, Amal
  • Licensing Officer: Flammang, Ann Marie

Device for Harvesting Vibration Energy to Power Remote Sensors or Feed the Power Grid
TS-049909 — A control method based upon properties of linear systems to manipulate the vibrational amplitudes and frequencies of structural systems by exploiting piecewise-linear (PWL) nonlinearities.
Energy harvesting from system vibrations is considered a promising green energy source with the capacity to both self-power small-scale devices and fulfill the need of large-scale electricity generation. A recent report by BCC research found that the markets for Vibration, Displacement, and Mechan…
  • College: College of Engineering (COE)
  • Inventors: D'Souza, Kiran; Tien, Meng-Hsuan
  • Licensing Officer: Zinn, Ryan

Point Prognostics: Closed Loop Particle Forecasting Platform for Decision Support and System Prognostics
TS-049903 — A scalable, adaptive computational platform (software) that performs accurate, predictive computer simulations in less time, with the end goal of supporting a decision-making agency
A report by IOT Analytics evaluated the predictive maintenance (PdM) market at $1.5 billion in 2016 and anticipated a growth of 39% annually to $10.96 billion by 2022. Particle methods (broadly known as "Monte Carlo'' methods, or, MC) are a class of computational algorithms used in Pd…
  • College: College of Engineering (COE)
  • Inventors: Kumar, Mrinal "Mrinal"; Yang, Chao "Chao"
  • Licensing Officer: Zinn, Ryan

Inhibition of DGAT for the treatment of cancer
TS-049730 — Dysregulated fat metabolism is an established hallmark of cancer cells. However, the disruption of lipid homeostasis in cancer cells remains an elusive target for therapy. Diacylglycerol-acyltransferase (DGAT) regulates the final and committed step for triglyceride synthesis. There are two known i…
  • College: College of Medicine (COM)
  • Inventors: Guo, Deliang
  • Licensing Officer: Ezzell, Janel

An improved base editor (iABE-NG) for correcting genetic diseases such as Duchenne muscular dystrophy
TS-049505 — An engineered base editor (iABE-NG) that uses an SpCas9 variant, a shortened adenine deaminase domain with eliminated RNA off-targeting activity, and an intein split for packaging into an adeno-associated virus (AAV), resulting in gene mutation correction.
There are thousands of monogenic diseases such as Duchenne muscular dystrophy (DMD) lacking effective therapeutic treatments. DMD is caused by genetic mutations in the DMD gene, which encodes the dystrophin protein. The mutations including missense point mutations, nonsense point mutations, deleti…
  • College: College of Medicine (COM)
  • Inventors: Han, Renzhi; Gao, Yandi; Xu, Li
  • Licensing Officer: Davis, Stewart

A Novel Vaccine for Listeriosis Infection
TS-049471 — Listeriosis is an infectious disease caused by the bacterial pathogen Listeria monocytogenes. Although the average number of cases is moderate in the United States (1600-2500/year), listeriosis is a significant health concern due to its exceptionally high fatality rate. Indeed, listeriosis is the …
  • College: OSU Wexner Medical Center
  • Inventors: Seveau, Stephanie
  • Licensing Officer: Ezzell, Janel

Portable and automated mechanical ventilator with renewable energy source for harsh or remote environments
TS-048975 — A mechanical ventilation device which incorporates a hand-crank to enable automated breathing assistance without the need for electrical outlets or external generators.
Mechanical ventilators have been developed to provide automated, life-sustaining assistance to individuals with difficulty breathing due to either injury or chronic illness. Current ventilator systems, however, are expensive, require constant medical supervision and require reliable electrical pow…
  • College: OSU Wexner Medical Center
  • Inventors: Vazquez, Daniel; Haney, Amanda; Skidmore, Jeffrey
  • Licensing Officer: Zinn, Ryan

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