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Self-assembled 3D RNA Cage Nanoparticles with Precise Shape and Size for Applications in Medical Sciences, Materials Sciences, Engineering and Nanotechnology
TS-039545 — Self-assembling, highly stable RNA cages amenable to custom functionalization and cargo delivery
One of the primary challenges in therapeutic development is cheap, efficient, and safe drug delivery to specific target tissues. To better target specific tissues, RNA nanotechnology has been progressively applied to generate predefined architectures via self-assembly of modular building blocks. N…
  • College: College of Pharmacy
  • Inventors: Guo, Peixuan; Jasinski, Daniel; Khisamutdinov, Emil; Li, Hui
  • Licensing Officer: Flammang, Ann Marie

Development of novel furano-parthenolides for human leukemia treatment
TS-038998 — Parthenolide analogues derived from plants could be effective in treating leukemia or supplementing other treatments.
The American Cancer Society estimates that in 2017 there will be about 1,688,780 new cancer cases diagnosed and 600,920 cancer deaths in the United States. Chemotherapy has improved, but further development is needed to improve the efficacy of this treatment, and cancers can develop multidrug resi…
  • College: College of Pharmacy
  • Inventors: Ren, Yulin
  • Licensing Officer: Flammang, Ann Marie

Productivity model for Advanced Practice Providers
TS-038991 — A new, well-rounded system of measuring APP productivity
Physician assistants (PAs) and nurse practitioners (NPs) are referred to as advanced practice providers (APPs). They are certified health care professionals that provide care and treatment to patients under a doctor's supervision. Although they are an integral part of many clinics and hospital…
  • College: OSU Wexner Medical Center
  • Inventors: Rosselet, Robin; Brom, Heather; Butz, Jenna; Cackler, Scott; Chen, Ting; Kent, Kelly; Kipp, Kris; Suwignjo, Ronny
  • Licensing Officer: Flammang, Ann Marie

A prototype device for applying beneficial mites to a greenhouse crop
TS-038983 — A method of evenly distributing beneficial mites throughout a greenhouse using a novel device.
Beneficial insects and mites feed on plant pests to improve overall plant health in greenhouses. Also called "biological controls," these mites are a valuable tool in pest management. Current distribution methods typically blow the mites over the crops, which result in uneven application…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Morse, Justin
  • Licensing Officer: Flammang, Ann Marie

Identification of a novel exercise-induced compound in breast milk that improves metabolic health of offspring.
TS-038700 — A novel exercise-induced compound in breast milk that improves metabolic health of offspring.
Type 2 diabetes is a complex disease that arises from a combination of environmental and genetic factors. Recent projections suggest that the prevalence of type 2 diabetes will increase to 25% of the U.S. population by 2050. While the incidence of the disease is rising, there is strong epidemiolog…
  • College: College of Medicine (COM)
  • Inventors: Stanford, Kristin; Bode, Lars
  • Licensing Officer: Flammang, Ann Marie

Development of a microRNA signature predicting local recurrence and overall survival after surgical resection for patients with pancreatic adenocarcinoma.
TS-038461 — A molecular tool for predicting risk of local and regional recurrence of pancreatic adenocarcinoma.
The median survival for patients with pancreatic adenocarcinoma is less than 4 months without treatment, although quick and effective treatments can increase this to 8 months. The five year survival rate is equally dismal at 8% and the disease is the fourth leading cause of cancer deaths in the Un…
  • College: College of Medicine (COM)
  • Inventors: Williams, Terence; Hite, Amy; Wald, Patrick
  • Licensing Officer: Rumpal, Nidhi

A novel synthetic immunomodulator and an adjuvant for vaccines
TS-038032 — A natural plant product possessing potent immunomodulatory activity, which primes T cell immune responses, and could be used for vaccine development.
While vaccines are commonly used today for a variety of diseases and have proven efficacious for disease prevention, some vaccines do not efficiently activate an immune response. Adjuvants can be included in a given vaccine to potentiate immune activation and improve the quality of the vaccine. Th…
  • College: College of Medicine (COM)
  • Inventors: Satoskar, Abhay; Ainslie, Kristy; Bachelder, Eric; Fuchs, James; Kinghorn, Douglas; Parinandi, Narasimham
  • Licensing Officer: Rumpal, Nidhi

Immobilization of Biomolecules (Rubisco) by Self-Assembled Nanostructures
TS-037787 — Nanostructures that enhance the stability of biocatalysts that permit them to be utilized in scalable CO2 conversion processes
Carbon dioxide (CO2) and methane (CH4) are the two most abundant greenhouse gasses, trapping thermal radiation close to the earth's atmosphere and contributing to climate change. These two gasses contributed up to 92% of all the greenhouse gas emissions in 2015 (epa.gov). From an industrial pe…
  • College: College of Arts & Sciences
  • Inventors: Parquette, Jonathan; Satagopan, Sriram; Sun, Yuan; Tabita, Fred
  • Licensing Officer: Flammang, Ann Marie

Thermogenic Biologicals for Obesity Treatment
TS-037747 — Identification and use of novel adipokines for reduction of visceral fat using thermogenesis.
The Need Obesity as a result of an increase in intra-abdominal (or visceral) fat is an independent risk factor for major diseases such as type 2 diabetes and cardiovascular diseases. Risk is increased with higher levels of intra-abdominal fat due to increases in insulin resistance and chronic infla…
  • College: College of Education & Human Ecology
  • Inventors: Ziouzenkova, Ouliana
  • Licensing Officer: Flammang, Ann Marie

Pyrrolopyrimidine Derivatives as Mps1/TTK Kinase Inhibitors for Cancer Therapy
TS-037724 — Small molecules for targeted treatment of triple negative breast cancer and other aggressive phenotypes.
Breast cancer is a heterogeneous group of tumors which can be subdivided based on histopathological features, genetic alterations, and gene-expression profiles. Approximately 50-60% of all breast cancer patients and two-thirds of postmenopausal breast cancer patients have estrogen receptor positiv…
  • College: College of Pharmacy
  • Inventors: Brueggemeier, Robert; Fisk, Harold; Li, Chenglong; Li, Pui-Kai "Tom"; Sugimoto, Yasuro
  • Licensing Officer: Rumpal, Nidhi

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