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Targeting β-catenin signaling in combination with EGFR TKI enhances progression free survival and overall survival of EGFR mutant NSCLC
TS-042666 — The discovery of a novel treatment for EGFR TKI drug resistance in NSCLC.
Non-small cell lung cancer (NSCLC), which accounts for 85% of all lung cancers, is one of the leading causes of cancer-related death. Substantial progress has been made in the management of NSCLC as several driver mutations have been identified in cell communication pathways involved in lung tumor…
  • College: College of Medicine (COM)
  • Inventors: Arasada, Rajeswara Rao; Carbone, David
  • Licensing Officer: Paschall, Christopher

Closed Loop Particle Forecasting Platform for Decision Support and System Prognostics.
TS-042531 — A computational platform for forecasting the state of evolving systems and processes.
Particle methods are a class of computational algorithms used to estimate potential outcomes of a system or process. Although popular for their simplicity and scalability, the use of fixed sized "particle ensembles" renders the simulations unable to provide performance guarantees in quan…
  • College: College of Engineering (COE)
  • Inventors: Kumar, Mrinal "Mrinal"; Yang, Chao "Chao"
  • Licensing Officer: Wohlgamuth, Christopher

High-strength and Corrosion Resistant Alloy for Patient-Specific Bioresorbable Bone Fixation Hardware
TS-042526 — Novel ternary and quaternary Mg-Zn-Ca-based alloys and a heat treatment process for producing bioresorbable bone fixation implants with improved mechanical and corrosion properties
Mg-Zn-Ca-based alloys are the most promising alloy system for bone implant applications mainly due to their superior biocompatibility. For fixation applications, the ideal is a material strong enough to hold while healing (2-4 months) yet being fully resorbed after the bones have healed (6-24 mont…
  • College: College of Medicine (COM)
  • Inventors: Dean, David; Elahinia, Mohammad; Ibrahim, Hamdy
  • Licensing Officer: Norris, Francis "Frank"

Drug Conjugated Lipid-based Nanomaterials and Biomedical Uses
TS-042128 — The creation of a library of anti-cancer drug conjugated nanomaterials for therapeutic applications.
Therapeutic cancer treatments often result in off-target side effects to healthy cells; improving the delivery of chemotherapy drugs to cancerous cells has the potential to reduce these occurrences and enhance the utility of the chemotherapeutics. Over the last several years, messenger RNA (mRNA)-…
  • College: College of Pharmacy
  • Inventors: Dong, Yizhou; Zhang, Chengxiang; Zhang, Xinfu
  • Licensing Officer: Dahlman, Jason "Jay"

miRNA Biomarkers for Diagnosis and Prediction of Radiation Induced Injury
TS-041968 — A minimally invasive procedure to determine radiation toxicity in victims of nucler events or radiation therapy patients.
The lack of a reliable radiation biodosimeter has been a major barrier to medical decision-making regarding the triage and treatment of persons - civilians, soldiers and first-time responders - who might be at risk for developing acute radiation syndromes (ARS) following nuclear events (e.g. nucle…
  • College: College of Medicine (COM)
  • Inventors: Jacob, Naduparambil "Naduparambil"
  • Licensing Officer: Norris, Francis "Frank"

Amine-Containing Facilitated Transport Membranes For Carbon Dioxide/Nitrogen Separation
TS-041856 — Novel membrane technology utilizing active transport for carbon dioxide/nitrogen separation. The membrane exhibits high permeance and selectivity
Improved separation of by-product carbon dioxide from nitrogen in power plants and industrial exhaust systems would considerably decrease greenhouse gas emissions. The current method of separation that is most often used in industry is amine absorption, however this method is costly, has a large c…
  • College: College of Engineering (COE)
  • Inventors: Ho, W.S. Winston; Han, Yang
  • Licensing Officer: Gooray, Arthur "Art"

DAtAnchor: A Multi-Layer Data Loss Mitigation System
TS-041846 — An alternative to traditional data security measures. The technology effectively "anchors" the information to one location, allowing for better security and making it harder to compromise access.
Data breaches are a looming risk for organizations that maintain significant repositories of sensitive data. The fundamental reason behind their inability to prevent them is the philosophy behind the current paradigm in data security: prevent all breaches at all times. Towards that end, existing a…
  • College: College of Engineering (COE)
  • Inventors: Koksal, C. Emre
  • Licensing Officer: Smith, Richard

Junctional Tourniquet for Groin and Axillary Regions
TS-041808 — A tourniquet with a ratcheting lock to keep pressure on wounds in the groin and axillary regions. Hemostasis can be achieved while the patient is still in the field.
Patients with blood loss in the field need to be treated immediately to prevent ongoing blood loss, shock, and death; bleeding from extremity and junctional wounds is the leading cause of potentially preventable death from penetrating injuries. Direct manual pressure is effective for the initial c…
  • College: OSU Wexner Medical Center
  • Inventors: McElroy, James; Graham, Nadi; Nocera, Tanya
  • Licensing Officer: Flammang, Ann Marie

Nonadhesive Medical Tube Attachment Device
TS-041656 — A device that holds nasogastric tubes, oxygen nasal cannulas, and facial dressings without adhesive.
Nasogastric tubes are used to give patients food and medications. Current commercially available tube holders are adhesive devices that attach to the nose. The devices put pressure on the nose and have to be completely removed to check the skin underneath or to adjust the tubes. Oxygen nasal cannu…
  • College: OSU Wexner Medical Center
  • Inventors: Huffman, Jennifer; West, Tabitha
  • Licensing Officer: Flammang, Ann Marie

FARM: Fertilizer Application Resource Monitor
TS-041592 — FARM is a real-time mobile application that uses precipitation forecasts to guide farmers in their use of fertilizer and pesticides.
Weather forecasting is a useful tool for farmers who need to decide how best to treat their crops. Applying fertilizer or pesticide to crops, just to have the rain wash it away, results in a waste of resources. Additionally, many areas such as Ohio have regulations for fertilizer and pesticide run…
  • College: Office of Academic Affairs
  • Inventors: Wilson, Aaron
  • Licensing Officer: Dahlman, Jason "Jay"

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