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Novel Large Scale All-Male Bluegill Production Technology & All-Female Yellow Perch Production Technology
TS-043636 — A novel technique for the large scale production of male bluegill (GMB) stock through selective breeding methods and for large scale production of all female yellow perch fish stock by means of dietary supplements. This technique improves growth rate, size, and survivability. For more information, please see related pdf upload.
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Wang, Hanping
  • Licensing Officer: Dahlman, Jason "Jay"

Composition and method of lipid nanoparticles carrying oligonucleotides
TS-043629 — Novel lipid nanoparticles used for carrying antisense oligonucleotides with improved targeting for cancer treatment
Lung cancer is the leading cause of cancer related deaths in the US with approximately 150,000 deaths in 2017. Currently, mildly ineffective chemotherapeutics ripe with adverse side effects are the standard treatment. Antisense oligonucleotides (ASOs) are able to selectively modulate expression of…
  • College: College of Pharmacy
  • Inventors: Lee, Robert; Cheng, Xinwei "Evan"
  • Licensing Officer: Flammang, Ann Marie

Cold responsive nanoparticles for overcoming cancer drug resistance
TS-043509 — A cold-responsive nanoparticle that quickly disassembles upon ice cooling leading to intracellular burst release of a chemotherapeutic drug in seconds
Stimuli-responsive nanoparticles (NPs) hold great promise for controlling drug release inside cancer cells. An obstacle to the effectiveness of this approach to chemotherapeutic drug delivery is the rapid expulsion of the delivered drug catalyzed by efflux pumps in the cell's plasma membrane. …
  • College: College of Engineering (COE)
  • Inventors: He, Xiaoming; Wang, Hai
  • Licensing Officer: Norris, Francis "Frank"

Folding Transducer Array for Compact and Deployable Wave-Energy Guiding System
TS-043186 — A novel acoustic/ultrasonic wave-energy guiding system that utilizes structural topology to enhance directional and spectral sensitivities instead of phase delay, offering exceptional versatility and adaptable performance.
Although acoustic beamforming systems that are based on phase delays can be used to enhance directional and spectral sensitivities, each source or receiver must be individually controlled by appropriate phase delays to guide the acoustic energy radiation/reception sensitivities. This results in a …
  • College: College of Engineering (COE)
  • Inventors: Harne, Ryan
  • Licensing Officer: Norris, Francis "Frank"

Louie: An Augmented Reality Sensory Trigger Wayfinding System for People with Autism
TS-043077 — An Augmented Reality Sensory Trigger Wayfinding System for People with Autism
Millions of people on the Autism spectrum face challenges getting from place to place due to sensory sensitivities to sounds, sights, smells, tastes, physical feelings, and crowds. Due to these triggers, people with Autism have a strong need to know where they are going and what will be there so t…
  • College: College of Engineering (COE)
  • Inventors: Ezell, Jonathan; Kaufman, Robert; Kaufman, Michael
  • Licensing Officer: Aanstoos, Megan

Targeting β-catenin signaling in combination with EGFR TKI enhances progression free survival and overall survival of EGFR mutant NSCLC
TS-042666 — The discovery of a novel treatment for EGFR TKI drug resistance in NSCLC.
Non-small cell lung cancer (NSCLC), which accounts for 85% of all lung cancers, is one of the leading causes of cancer-related death. Substantial progress has been made in the management of NSCLC as several driver mutations have been identified in cell communication pathways involved in lung tumor…
  • College: College of Medicine (COM)
  • Inventors: Arasada, Rajeswara Rao; Carbone, David
  • Licensing Officer: Paschall, Christopher

Closed Loop Particle Forecasting Platform for Decision Support and System Prognostics.
TS-042531 — A computational platform for forecasting the state of evolving systems and processes.
Particle methods are a class of computational algorithms used to estimate potential outcomes of a system or process. Although popular for their simplicity and scalability, the use of fixed sized "particle ensembles" renders the simulations unable to provide performance guarantees in quan…
  • College: College of Engineering (COE)
  • Inventors: Kumar, Mrinal "Mrinal"; Yang, Chao "Chao"
  • Licensing Officer: Wohlgamuth, Christopher

High-strength and Corrosion Resistant Alloy for Patient-Specific Bioresorbable Bone Fixation Hardware
TS-042526 — Novel ternary and quaternary Mg-Zn-Ca-based alloys and a heat treatment process for producing bioresorbable bone fixation implants with improved mechanical and corrosion properties
Mg-Zn-Ca-based alloys are the most promising alloy system for bone implant applications mainly due to their superior biocompatibility. For fixation applications, the ideal is a material strong enough to hold while healing (2-4 months) yet being fully resorbed after the bones have healed (6-24 mont…
  • College: College of Medicine (COM)
  • Inventors: Dean, David; Elahinia, Mohammad; Ibrahim, Hamdy
  • Licensing Officer: Norris, Francis "Frank"

Machine-Learning Algorithm for Improved Speech Intelligibility in Noise
TS-042266 — A monaural machine-learning algorithm for classifying time-frequency units in an unknown signal, which results in marked speech-intelligibly improvements in noisy signals.
A primary complaint of hearing-impaired (HI) listeners is poor speech recognition in background noise. This issue can be quite debilitating and persists despite considerable efforts to improve hearing technology. Despite considerable effort, monaural (single-microphone) algorithms capable of incre…
  • College: College of Arts & Sciences
  • Inventors: Healy, Eric; Vasko, Jordan
  • Licensing Officer: Dahlman, Jason "Jay"

Drug Conjugated Lipid-based Nanomaterials and Biomedical Uses
TS-042128 — The creation of a library of anti-cancer drug conjugated nanomaterials for therapeutic applications.
Therapeutic cancer treatments often result in off-target side effects to healthy cells; improving the delivery of chemotherapy drugs to cancerous cells has the potential to reduce these occurrences and enhance the utility of the chemotherapeutics. Over the last several years, messenger RNA (mRNA)-…
  • College: College of Pharmacy
  • Inventors: Dong, Yizhou; Zhang, Chengxiang; Zhang, Xinfu
  • Licensing Officer: Dahlman, Jason "Jay"

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