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Novel acellular vaccine for protection against Bordetella infection
TS-050524 — Despite high vaccine coverage, whooping cough caused by Bordetella pertussis remains one of the most common vaccine-preventable diseases worldwide. Introduction of whole-cell pertussis (wP) vaccines in the 1940s and acellular pertussis (aP) vaccines in 1990s reduced mortality due to pertussis. Des…
  • College: College of Medicine (COM)
  • Inventors: Deora, Rajendar; Mishra, Meenu; Sukumar, Neelima
  • Licensing Officer: Ezzell, Janel

Method for seamless joining and repair of metal parts using ultrasonic additive manufacturing
TS-050479 — This invention provides a method for repairing metal parts by removing and replacing worn, damaged, or defective metal material. It also serves as a method for seamlessly joining metal sheets and other parts while retaining the original temper of the joined parts. This technology, based on ultrasonic additive manufacturing (UAM), achieves strong joints and repairs by enabling the filling of a channel that has been cut, formed, or otherwise created in a metal structure or between two metal structures.
The aircraft industry lacks a robust method for joining metal sheets, structures, and assemblies together in wings, fuselages, and engines. Fusion based welding methods cannot always be used because they create heat-affected zones, which reduce the mechanical performance of material around the wel…
  • College: College of Engineering (COE)
  • Inventors: Dapino, Marcelo; Gingerich, Mark; Headings, Leon
  • Licensing Officer: Zinn, Ryan

Out-of-Plane Fluidic Actuator for Curved Surface Applications
TS-050464 — A novel bistable fluidic actuator design which uses naturally occurring fluid dynamic instabilities instead of moving parts to create an oscillating jet that is out-of-plane from the fluid inlet port.
Turbines are used to produce much of the world’s electricity, whether it be from nuclear, coal, or natural gas sources, as well as provide power for the vast majority of aircraft flying today. For many turbine applications, the first stage vane and blade just downstream of the combustor is a…
  • College: College of Engineering (COE)
  • Inventors: Hossain, Mohammad Arif "Arif"; Ameri, Ali; Bons, Jeffrey; Gregory, James "Jim"
  • Licensing Officer: Zinn, Ryan

Out-of-Plane Fluidic Actuator for Curved Surface Applications
TS-050464 — A novel bistable fluidic actuator design which uses naturally occurring fluid dynamic instabilities instead of moving parts to create an oscillating jet that is out-of-plane from the fluid inlet port.
Turbines are used to produce much of the world’s electricity, whether it be from nuclear, coal, or natural gas sources, as well as provide power for the vast majority of aircraft flying today. For many turbine applications, the first stage vane and blade just downstream of the combustor is a…
  • College: College of Engineering (COE)
  • Inventors: Hossain, Mohammad Arif "Arif"; Ameri, Ali; Bons, Jeffrey; Gregory, James "Jim"
  • Licensing Officer: Zinn, Ryan

Mini-PCDH15 for treatment of deafness
TS-050433 — A gene therapy solution for Usher Syndrome Type 1F.
Mutations in PCDH15 cause Usher 1F, a recessive syndrome characterized by profound congenital deafness and absence of vestibular function, and progressive blindness beginning in the second decade. Because patients who lack hearing and balance rely on vision for communication and mobility, the late…
  • College: College of Arts & Sciences
  • Inventors: Sotomayor, Marcos
  • Licensing Officer: Ezzell, Janel

Smart Platform for Engineered Electroceutical Dressings (SPEEDs) Enables Better Wound Care
TS-050245 — An integrated platform with multiple sensing modalities to actively orchestrate antimicrobial activity and wound healing.
Wound healing and disinfection for chronic wounds presents significant hurdles within the medical industry. Current state of art is inadequate and adds a significant cost burden to the healthcare system with many health and life-quality challenges for patients. After the formation of an open wound…
  • College: College of Engineering (COE)
  • Inventors: Prakash, Shaurya; Heald, Rachel; Mohana Sundaram, Prashanth; Narayanan, Kavya; Stoodley, Paul; Subramaniam, Vishwanath; Vilku, Gurleen; Wilgus, Traci; Wozniak, Daniel
  • Licensing Officer: Hong, Dongsung

Scalable laser-assisted MOCVD chamber design with laser array input
TS-050244 — A design of scalable laser-assisted MOCVD chamber for III-nitrides and other semiconductors with a laser array input.
III-nitrides represent an important semiconductor material system for both optoelectronic and power electronic device applications. Advantages for III-nitrides include high electron saturation velocity, high critical electric field, high radiation resistance and decent thermal performance. Therefo…
  • College: College of Engineering (COE)
  • Inventors: Zhao, Hongping; Chen, Zhaoying
  • Licensing Officer: Hong, Dongsung

Privacy-preserving Acoustic Signal based Encounter Detection in Physical Proximity
TS-050242 — A continuous on-line machine learning algorithm to sense and analyze the acoustic channels of surrounding environments first, and then dynamically adjust power, coding strategies and back-off mechanisms for real-time acoustic communications.
In light of the COVID-19 Pandemic, the world is looking to data which quantifies the self-quarantine measures, tracks encounters and viral spread, and provides other indicators that can be used for safety. WiFi and Bluetooth signals are relatively large which makes virus detection/tracking difficu…
  • College: College of Engineering (COE)
  • Inventors: Xuan, Dong; Luo, Yuxiang; Shroff, Ness; Zhang, Yunqi; Zhang, Cheng
  • Licensing Officer: Hong, Dongsung

Apoprotein manufacturing and methods for protein purification
TS-050238 — Methods of purifying proteins that can be used in various applications such as drug delivery, bioimaging and hemolysis treatment.
Novel protein and apoprotein purification strategies are valuable tools with a wide variety of medical and research applications. While there are existing techniques for protein and apoprotein purification, some of these have flaws such as the use of harsh denaturants, highly flammable solvents, l…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Cabrales, Pedro; Palmer, Andre
  • Licensing Officer: Davis, Stewart

Apoprotein manufacturing and methods for protein purification
TS-050238 — Methods of purifying proteins that can be used in various applications such as drug delivery, bioimaging and hemolysis treatment.
Novel protein and apoprotein purification strategies are valuable tools with a wide variety of medical and research applications. While there are existing techniques for protein and apoprotein purification, some of these have flaws such as the use of harsh denaturants, highly flammable solvents, l…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Cabrales, Pedro; Palmer, Andre
  • Licensing Officer: Davis, Stewart

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