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AI-Enabled Retrosynthesis for Drug Development
TS-060092 — AI methods and systems for predicting reactants and their synthesis paths to support drug design and chemical synthesis.
A time-consuming and costly step in drug development is the identification of drug-like small molecules that display desired properties against a specific biomolecular target and then the synthesis of such molecules if they do not exist. Retrosynthesis is a procedure where such a desired molecule i…
  • College: College of Medicine (COM)
  • Inventors: Ning, Xia; Chen, Ziqi
  • Licensing Officer: Csatary, Erika

FraB as a drug target and FraB inhibitors as Salmonella-specific narrow-spectrum therapeutics
TS-059635 — & T2014-282 A method to discover narrow-spectrum antibiotics of salmonellosis, as well as small molecule inhibitors of Salmonella FraB and a Salmonella probiotic strain to enhance the efficacy of FraB inhibitors.
Non-typhoidal salmonellosis is one of the most significant food-borne diseases, in the United States and globally. There are no vaccines available for human use to prevent this disease, and only broad-spectrum antibiotics available to treat the disease. However, antibiotic resistance is on the ris…
  • College: College of Medicine (COM)
  • Inventors: Ahmer, Brian; Boulanger, Erin; Cool, Austin; Gopalan, Venkat; Kovvali, Sai Sravya Varali; Law, Jamison; Lindert, Steffen; Sabag-Daigle, Anice; Sengupta, Anindita; Thirugnanasambantham, Pankajavalli
  • Licensing Officer: Csatary, Erika

Diagnostic for Early Detection of Heart Damage
TS-059578 — A novel biomarker for the early identification of cardiac damage, including chemotherapy-induced cardiotoxicity.
Despite significant medical advances and technologies, cardiovascular disease remains the number one cause of death in the United States, irrespective of gender or race, resulting in more than 600,000 annual deaths. Additionally, while cancer survivorship has increased significantly, the number one …
  • College: College of Medicine (COM)
  • Inventors: Smith, Sakima; Dib, Patrick; McElroy, Craig
  • Licensing Officer: Csatary, Erika

Metabolite-Based Diagnostics for Joint Infection
TS-059537 — An untargeted NMR-based metabolomics approach to identify metabolic compounds as signatures of bacterial joint infections and methods for the treatment and prevention thereof.
Pseudomonas aeruginosa, a biofilm-producing pathogenic bacterium, exhibits resistance to many antibiotics. This leads to acute and chronic joint infections that are difficult to treat. Accordingly, a critical need exists for accurate biofilm diagnosis, prevention, and treatment. While culture-free…
  • College: College of Medicine (COM)
  • Inventors: Stoodley, Paul; Bruschweiler, Rafael; Leggett, Abigail
  • Licensing Officer: Csatary, Erika

High Purity Extraction of Rubber From Taraxacum
TS-059106 — Rubber is a crucial material used worldwide, but it is becoming scarce due to high demand and limited areas to grow rubber trees. New methods and processes are needed to overcome the shortage of this essential material.
The Need Natural rubber is a critical raw material in many industrial supply chains because of its unique properties, such as high durability, flexibility, and water resistance, make it invaluable for a wide range of products, including high-performance auto and aircraft tires, electronic cables, a…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Michel, Frederick; Ramirez Cadavid, David
  • Licensing Officer: Dahlman, Jason "Jay"

A low input high yield indoor food production module
TS-059105 — Food shortages around the world affect hundreds of millions of people daily due to environmental and political issues. New technologies are needed to improve the quantity and quality of food in resource-limited areas.
The Need Globally, about 690 million people regularly go to bed hungry, which is expected to rise to more than 890 million by 2030. Food shortages are commonly caused by drought, pests, too much rain, land shortages, and political unrest. As a result, there is an unmet need to develop new technolog…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Ling, Peter; Tkach, Christopher
  • Licensing Officer: Dahlman, Jason "Jay"

Temperature-sensitive SARS-CoV-2 mutant TS11 for vaccine development
TS-059103 — Novel temperature-sensitive SARS-CoV-2 mutant
Current COVID-19 vaccines (mRNA, adenovirus vector, inactivated, S protein) are effective in preventing severe COVID-19 cases and deaths. However, they do not prevent infection/virus transmission and as the virus continues to evolve, S mutants may emerge that can escape current vaccine-induced immun…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Wang, Qiuhong; Liu, Mingde; Niu, Xiaoyu; Saif, Linda; Xu, Jiayu
  • Licensing Officer: Dahlman, Jason "Jay"

SimPi: A Remote Power Platform for Simulation
TS-059056 — A platform for improving simulations across many industries. Developing real-life simulations of disasters is vital for safety and reducing their financial impact; however, current simulation tools are bulky, expensive to implement, and require advanced technical skills to operate.
Simulations are essential for evaluating the potential impacts of disasters and for creating effective preparedness and response plans to facilitate organized and coordinated actions. Since response plans are not theoretical exercises, they must frequently be tested to be evaluated, adapted, and u…
  • College: College of Medicine (COM)
  • Inventors: Winfield, Scott; Beck, James; Finnegan, Geoff
  • Licensing Officer: Csatary, Erika

DAT-CI knock-in mouse model carrying a modified dopamine transporter that maintains the transport function but resistant to cocaine inhibition and thus showing no rewarding cocaine effects
TS-058669 — A knock-in mouse model carrying a modified dopamine transporter that is resistant to cocaine inhibition and thus showing no rewarding cocaine effects.
Cocaine abuse has been an issue in the United States since the late 1980s. The highly addictive qualities along with the low cost ruined people’s lives and destroyed communities. Naloxone (marketed as Narcan) is highly effective but can only be used in the event of an overdose. Therefore, th…
  • College: College of Medicine (COM)
  • Inventors: Gu, Howard
  • Licensing Officer: Davis, Stewart

NET-CI knock-in mouse model with a modified norepinephrine transporter carrying triple mutations that maintains the transport function and makes the transporter protein resistant to cocaine and antidepressants
TS-058668 — A knock-in mouse model with a modified norepinephrine transporter carrying triple mutations that makes the transporter protein resistant to cocaine and antidepressants.
Cocaine abuse has been an issue in the United States since the late 1980s. Furthermore, antidepressants also quite dangerous, with nearly 14% of users (who have bipolar disorder) experiencing dependence. Naloxone (marketed as Narcan) is highly effective but can only be used in the event of an over…
  • College: College of Medicine (COM)
  • Inventors: Gu, Howard
  • Licensing Officer: Davis, Stewart

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