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Method to improve natural rubber (hevea/guayule)-toughened poly-(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) for food packaging applications
TS-044688 — Nearly all plastics that are used to produce packaging materials are petroleum-based and non-biodegradable. This makes their use undesirable to consumers in an increasingly sustainability-focused market. Therefore, the development of biologically-derived, biodegradable plastic for packaging materi…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Vodovotz, Yael; Cornish, Katrina; Koelling, Kurt; Venoor, Varun "varun"; Zhao, Xiaoying "Xiaoying"
  • Licensing Officer: Dahlman, Jason "Jay"

Nanoparticle Composition for Nucleic Acid Delivery
TS-044109 — Lipid nanoparticles (LNs) usable for the delivery of therapeutic compositions, including, but not limited to nucleic acids (NAs).
Nucleic Acid (NA) based therapies are used to inhibit gene expression. Lipid nanoparticles (LNs) are capable of carrying these therapies into cells. However, this delivery requires overcoming several physiological barriers. For instance, one barrier is the acidic endosome conditions within the cel…
  • College: College of Pharmacy
  • Inventors: Lee, Robert
  • Licensing Officer: Flammang, Ann Marie

High-strength and Corrosion Resistant Alloy for Patient-Specific Bioresorbable Bone Fixation Hardware
TS-042526 — Novel ternary and quaternary Mg-Zn-Ca-based alloys and a heat treatment process for producing bioresorbable bone fixation implants with improved mechanical and corrosion properties
Mg-Zn-Ca-based alloys are the most promising alloy system for bone implant applications mainly due to their superior biocompatibility. For fixation applications, the ideal is a material strong enough to hold while healing (2-4 months) yet being fully resorbed after the bones have healed (6-24 mont…
  • College: College of Medicine (COM)
  • Inventors: Dean, David; Elahinia, Mohammad; Ibrahim, Hamdy
  • Licensing Officer: Norris, Francis "Frank"

RNA Nanotubes for Single Molecule Sensing and DNA/RNA/Protein Sequencing
TS-039514 — Stable, predictably ordered RNA nanopores for disease diagnosis and biopolymer sequencing.
New rapid and accurate sequencing methods, and disease detection methods are always in high demand. Newer advances in these areas include membrane-anchored structures and synthetics, which allow molecule idenfication and biopolymer sequencing by measuring conductance changes associated with passag…
  • College: College of Pharmacy
  • Inventors: Guo, Peixuan; Li, Hui; Wang, Shaoying
  • Licensing Officer: Flammang, Ann Marie

Novel small peptide polarizing agents for dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) spectroscopy
TS-038322 — Versatile small biradical peptide molecules that can serve as biradical polarizing agents for dynamic nuclear polarization (DNP) solid-state nuclear magnetic resonance spectroscopy.
DNP methodology offers dramatic sensitivity enhancements of NMR experiments (up to 1-2 orders of magnitude) by transferring the large electron spin polarization to the nuclei of interest, and is currently one of the research frontiers in the magnetic resonance field with numerous applications to b…
  • College: College of Arts & Sciences
  • Inventors: Jaroniec, Christopher; Conroy, Daniel
  • Licensing Officer: Norris, Francis "Frank"

Electrolyte to Enable Reversible Dendrite-Free Potassium Plating and Stripping for Potassium Secondary Batteries
TS-037854 — A novel electrolyte to prevent dendrite growth in potassium air batteries.
The Need Potassium-air batteries have recently emerged as alternative energy storage devices beyond lithium-ion batteries. However, potassium metal anodes suffer from poor reversibility during plating and stripping processes due to their high reactivity and unstable solid electrolyte interphase (SE…
  • College: College of Arts & Sciences
  • Inventors: Wu, Yiying; McCulloch, William; Xiao, Neng
  • Licensing Officer: Smith, Richard

Nanopump Separation Device and Method
TS-037584 — A device for separating macromolecules in a solution of macromolecules having different molecular sizes
Many clinical and research applications involve separation of specific biological molecules, such as nucleic acids and proteins, for further analysis and characterization. A complex biological system can only be understood after each component has been separately analyzed, and proteins must be pur…
  • College: College of Engineering (COE)
  • Inventors: Hansford, Derek; Walczak, Robbie
  • Licensing Officer: Smith, Richard

A Gas-Assisted Resin Injection Technique for Bonding and Surface Modification of Microfluidic Devices
TS-037577 — A new resin gas-assisted injection technique, which can achieve both bonding and surface modification of microfluidic devices
The application of microfluidic platforms is limited because the materials and production methods are too expensive, and the material properties induce problems, such as a lack of optical clarity and low impact strength. Packaging (i.e. sealing a device with a lid) is also a challenge in the fabri…
  • College: College of Engineering (COE)
  • Inventors: Lee, L James; Lai, Siyi
  • Licensing Officer: Smith, Richard

Metabolic Engineering of Clostridium Tyrobutyricum for Butanol Production
TS-037555 — A new strain of bacteria that can produce butanol at a high titer for transportation fuel.
Butanol is generally used as an industrial solvent but can also be blended with gasoline and used as transportation fuel. Butanol is commonly produced using fossil fuels, but it can also be produced from biomass, referred to as biobutanol. Biobutanol is produced from fermentation of the same feeds…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Yu, Mingrui
  • Licensing Officer: Davis, Stewart

Al-Cr-Ti-V Based High Entropy Alloys
TS-037543 — Innovative alloys displaying extremely high strength and improving upon other mechanical properties
High entropy alloys (HEA) are a new class of multiple-principle-element alloys stabilized by large configurational entropy. HEA offer exceptional mechanical, chemical, and magnetic properties at room and elevated temperatures. Current efforts in the HEA field have focused on developing new materia…
  • College: College of Engineering (COE)
  • Inventors: Luo, Aihua "Alan"; Huang, Xuejun; Sun, Weihua
  • Licensing Officer: Smith, Richard

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