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Integrated Biomanufacturing System for Fiber-Reinforced Tissue Composites
TS-047830 — An automated technique and system which combines electrospinning, additive manufacturing, and cell dispensing for generating high-quality tissue constructs with high physiological relevance.
Recent advances in biofabrication introduced by additive manufacturing/3D printing (AM/3DP) have significantly improved the overall architecture control in tissue engineered constructs. These constructs have a wide variety of important research and clinical applications including, but not limited …
  • College: College of Engineering (COE)
  • Inventors: Zhang, Xu; Herderick, Edward; Niu, Ye "Ye"; Zhao, Yi
  • Licensing Officer: Zinn, Ryan

Gas Sensors for Health Monitoring and Diagnostics
TS-047136 — A range of low-cost gas sensors for non-invasive diagnostic tests and health monitoring.
Exhaled human breath is a combination of hundreds of gases including inorganic molecules such as NO, NH3 or CO, and volatile organic molecules such as acetone, ethane, and isoprene. Some of these gases are produced by the body as the result of physiological processes. Known as ‘biomarkers&rs…
  • College: College of Engineering (COE)
  • Inventors: Gouma, Pelagia-Iren
  • Licensing Officer: Gooray, Arthur "Art"

ReScribe: Transcription factors for reprogramming of diseased musculoskeletal related cells
TS-046978 — Transcription factors that can upregulate desired genes in diseased tissue to reprogram diseased cells, thereby reversing the disease and creating healthy non-diseased phenotype genes. These transcription factors would be especially useful in musculoskeletal diseases such as back pain and osteoarthritis.
Musculoskeletal diseases including osteoarthritis and chronic low back pain, are debilitating, painful, and often difficult to treat. Intervertebral disc (IVD) degeneration, as an example, is strongly associated with low back pain, a leading cause of disability worldwide. According to the American…
  • College: College of Engineering (COE)
  • Inventors: Walter, Devina; Gallego Perez, Daniel; Higuita Castro, Natalia; Hoyland, Judith; Khan, Safdar; Tang, Shirley "Shirley Nina"; Walter, Benjamin
  • Licensing Officer: Aanstoos, Megan

Folding Transducer Array for Compact and Deployable Wave-Energy Guiding System
TS-043186 — A novel acoustic/ultrasonic wave-energy guiding system that utilizes structural topology to enhance directional and spectral sensitivities instead of phase delay, offering exceptional versatility and adaptable performance.
Although acoustic beamforming systems that are based on phase delays can be used to enhance directional and spectral sensitivities, each source or receiver must be individually controlled by appropriate phase delays to guide the acoustic energy radiation/reception sensitivities. This results in a …
  • College: College of Engineering (COE)
  • Inventors: Harne, Ryan
  • Licensing Officer: Norris, Francis "Frank"

High-strength and Corrosion Resistant Alloy for Patient-Specific Bioresorbable Bone Fixation Hardware
TS-042526 — Novel ternary and quaternary Mg-Zn-Ca-based alloys and a heat treatment process for producing bioresorbable bone fixation implants with improved mechanical and corrosion properties
Mg-Zn-Ca-based alloys are the most promising alloy system for bone implant applications mainly due to their superior biocompatibility. For fixation applications, the ideal is a material strong enough to hold while healing (2-4 months) yet being fully resorbed after the bones have healed (6-24 mont…
  • College: College of Medicine (COM)
  • Inventors: Dean, David; Elahinia, Mohammad; Ibrahim, Hamdy
  • Licensing Officer: Norris, Francis "Frank"

Machine-Learning Algorithm for Improved Speech Intelligibility in Noise
TS-042266 — A monaural machine-learning algorithm for classifying time-frequency units in an unknown signal, which results in marked speech-intelligibly improvements in noisy signals.
A primary complaint of hearing-impaired (HI) listeners is poor speech recognition in background noise. This issue can be quite debilitating and persists despite considerable efforts to improve hearing technology. Despite considerable effort, monaural (single-microphone) algorithms capable of incre…
  • College: College of Arts & Sciences
  • Inventors: Healy, Eric; Vasko, Jordan
  • Licensing Officer: Hong, Dongsung

Junctional Tourniquet for Groin and Axillary Regions
TS-041808 — A tourniquet with a ratcheting lock to keep pressure on wounds in the groin and axillary regions. Hemostasis can be achieved while the patient is still in the field.
Patients with blood loss in the field need to be treated immediately to prevent ongoing blood loss, shock, and death; bleeding from extremity and junctional wounds is the leading cause of potentially preventable death from penetrating injuries. Direct manual pressure is effective for the initial c…
  • College: OSU Wexner Medical Center
  • Inventors: McElroy, James; Graham, Nadi; Nocera, Tanya
  • Licensing Officer: Flammang, Ann Marie

Virtual image generation of immunohistochemical stained tissue sections using an artificial neural network
TS-039781 — Realistic immunohistochemical stained tissue section databases for training, certification, and machine standards.
Immunohistochemistry (IHC) is used to determine antigen distribution in a tissue and is widely used for diagnosis of cancers and other diseases. Diagnostic and research laboratories in the United States use locally devised IHC tissue slide preparation and scanning protocols to check scanner perfor…
  • College: College of Medicine (COM)
  • Inventors: Gurcan, Metin; Lozanski, Gerard; Senaras, Caglar
  • Licensing Officer: Norris, Francis "Frank"

Perivascular Drug Delivery Nanoplatform for Preventing Restenosis After Open Surgery
TS-039004 — Pericelle: a nanoparticle based perivascular drug delivery system to prevent stenosis and failure in vascular reconstruction surgeries
Imaging and re-intervention procedures, necessary to maintain open blood vessels following vascular reconstruction surgery, are expensive. For example, the cost of maintenance for an atriovenous (AV) fistula used in hemodialysis access has been estimated at near a staggering $15,000/year. In bypas…
  • College: College of Medicine (COM)
  • Inventors: Kent, K. Craig; Chen, Guojun; Gong, Shaoqin; Guo, Lianwang; Shi, Xudong
  • Licensing Officer: Norris, Francis "Frank"

Machine-Learning Algorithm for Improved Speech Intelligibility in Noise
TS-038074 — A monaural machine-learning algorithm for classifying time-frequency units in an unknown signal, which results in marked speech-intelligibly improvements in noisy signals.
Wireless carriers receive daily complaints about poor speech recognition in background noise during calls and are constantly looking for methods to improve especially in light of recent forays into VOIP. The ability to discriminate between speech and noise in an audio signal then is an extremely i…
  • College: College of Arts & Sciences
  • Inventors: Healy, Eric; Vasko, Jordan
  • Licensing Officer: Hong, Dongsung

Six Degrees-of-Freedom Quality Assurance Phantom for Radiation Therapy Linear Accelerators
TS-037968 — The medical physics group in the Department of Radiation Oncology has devised a 6DoF phantom that is the first of its kind to fully integrate multiple routine QA tests specifically for a six degrees-of-freedom linac table.
6DoF treatment tables allow for 2 additional degrees (pitch and roll) compared to traditional 4DoF (vertical, lateral, longitudinal, and yaw) when correcting for patient setup during image-guidance prior to treatment delivery. These tables allow for more accurate patient treatments and could poten…
  • College: OSU Wexner Medical Center
  • Inventors: Woods, Kyle; Ayan, Ahmet; Gupta, Nilendu; Woollard, Jeffrey
  • Licensing Officer: Norris, Francis "Frank"

Rapid detection and monitoring of visual field loss at home or in the clinic with simple instrumentation
TS-037934 — A kit that lay individuals or healthcare practitioners can use on a tablet or other mobile device to evaluate visual field loss using a rapid, self-administered test.
Individuals with diseases affecting the eye or brain are susceptible to losing parts of their visual field of view. The loss can be central (e.g. AMD), peripheral (e.g. glaucoma) or sectoral (e.g. stroke). Although there are therapy options to address such visual field loss, compromised vision can…
  • College: College of Optometry
  • Inventors: Ooi, Teng Leng "Teng Leng"
  • Licensing Officer: Norris, Francis "Frank"

A Closed Loop System for Responsive Precise Intraparenchymal Delivery of Adenosine for the Treatment of Epilepsy
TS-037644 — Medical device for controlling seizures.
Adenosinergic neuromodulation plays a crucial role in control of seizure activity and is described as the brain's endogenous anticonvulsant. Intraparenchymal infusion of adenosine into epileptogenic regions of the brain has been shown to control seizures (anti-ictogenic) and prevent progressiv…
  • College: College of Medicine (COM)
  • Inventors: Oluigbo, Chima
  • Licensing Officer: Davis, Stewart

Nanopump Separation Device and Method
TS-037584 — A device for separating macromolecules in a solution of macromolecules having different molecular sizes
Many clinical and research applications involve separation of specific biological molecules, such as nucleic acids and proteins, for further analysis and characterization. A complex biological system can only be understood after each component has been separately analyzed, and proteins must be pur…
  • College: College of Engineering (COE)
  • Inventors: Hansford, Derek; Walczak, Robbie
  • Licensing Officer: Ezzell, Janel

A Wearable Integrated System of Augmented Reality for Targeted Pathologic Specimen Sampling
TS-037535 — An integrated system to improve the quality of analysis of the resected tumor specimen that provides the pathologist with the latest technological and scientific advancements.
In the field of cancer pathology, the identification and sampling of tumors is essential for both surgical applications and treatment plans for patients that may include post-operative chemotherapy and/or radiation therapy. Currently pathologists and pathologist assistants rely on visual and tacti…
  • College: College of Engineering (COE)
  • Inventors: Yilmaz, Alper; Hall, Nathan; Hitchcock, Charles; Lee, Young Jin; Martin, Edward; Nichols, Shawnn; Ozer, Enver; Povoski, Stephen; Sachire, Jennifer; Xu, Ronald
  • Licensing Officer: Norris, Francis "Frank"

Time Management Facilitator
TS-037366 — A novel device to reinforce the abstract concept of time to intellectually disabled children, especially those with Down syndrome.
Learning and understanding the abstract and intangible concept of time is especially difficult for children with Down Syndrome. This difficulty can cause deep frustration because it affects the family’s daily routine and reduces the child’s independence in the home, at school, and even…
  • College: College of Engineering (COE)
  • Inventors: Rogers, Peter "Peter"; Alley, Krista; Cornelius, Kristen; Dew, Elise; Hegedus, Alexander; Johnson, Kyle; Shiroma, Cecilia; Weisbecker, Carolyn; Whitehouse, Katherine
  • Licensing Officer: Aanstoos, Megan

Joint Stability Measurement Device for Total Knee Arthroplasty
TS-015289 — A device to intra-operatively measure varus/valgus, internal/external, and anterior/posterior stability for total knee arthroplasty
Total knee arthroplasty (TKA) is performed to relieve pain and disability associated with degenerative joint disease. Joint instability remains a leading cause of revision surgery following TKA. During the surgery, indicators of stability such as joint space are used to balance the knee. Many devi…
  • College: College of Engineering (COE)
  • Inventors: Siston, Robert; Maack, Thomas; Maack, Horst; Van Gorp, Cornel
  • Licensing Officer: Aanstoos, Megan

Non-Invasive Electromagnetic Method for Continuous Detection and Monitoring of Malaria
TS-015267 — An inexpensive device that utilizes non-invasive electromagnetic interactions with red blood cells to provide continuous monitoring for or diagnosis of malaria.
Plasmodium falciparum (PF), a form of malaria, is the deadliest and most prevalent parasite in humans due to its pervasiveness in temperate areas of the underdeveloped world. In 2013, there were nearly 198 million cases of malaria and an estimated 584,000 deaths, mostly among African children (BCC…
  • College: College of Engineering (COE)
  • Inventors: Subramaniam, Vishwanath; Drew, Mark; Smith, Brad; West, Joseph
  • Licensing Officer: Paschall, Christopher

SmartHub Wheelchair Fitness Tracker
TS-015141 — The SmartHub is a personal fitness and activity tracking device designed for manual wheelchair users.
Fitness tracking technology has boomed in recent years. However, none of the technology that has been sold has been useable by those in wheelchairs. Either these devices rely on total body movement or the algorithms are not adapted for movement in a wheelchair instead of by walking upright. Many p…
  • College: College of Engineering (COE)
  • Inventors: Metzler, Sandra; DiGiovine, Carmen; Eakins, Kyle; Mubaslat, Jad; Nishio, Lee; Shaffer, Sarah
  • Licensing Officer: Hong, Dongsung

Non-Contact Method for Accelerating Wound Healing
TS-015075 — Novel non-contact method for healing surface or deep wounds by inducing electric fields by applying time-varying magnetic fields.
The directional movement of biological cells in the presence of an applied electric field is known as galvanotaxis or electrotaxis. The majority of experiments related to galvanotaxis over the past two centuries have involved steady electric fields applied via electrodes placed in contact with a m…
  • College: College of Engineering (COE)
  • Inventors: Subramaniam, Vishwanath; Das Ghatak, Piya; Roy, Sashwati; Sen, Chandan; Sequin, Emily; West, Joseph
  • Licensing Officer: Paschall, Christopher

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