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Pulse of the OR: Reducing Operating Room Traffic for Patient Safety and Quality Initiatives
TS-039735 — A method of measuring traffic flow in an operating room to reduce contamination and ensure air quality.
Surgical site infections (SSI) can affect all surgical specialties and are an significant cause of long-term morbidity and mortality in the United States. With a rate of 2.8 infections per every 100 operations, these occurrences can lengthen hospital stays, double readmission rates, and can cost b…
  • College: College of Medicine (COM)
  • Inventors: Quatman, Carmen; Chaudhari, Ajit
  • Licensing Officer: Flammang, Ann Marie

RNA Nanotubes for Single Molecule Sensing and DNA/RNA/Protein Sequencing
TS-039514 — Stable, predictably ordered RNA nanopores for disease diagnosis and biopolymer sequencing.
New rapid and accurate sequencing methods, and disease detection methods are always in high demand. Newer advances in these areas include membrane-anchored structures and synthetics, which allow molecule idenfication and biopolymer sequencing by measuring conductance changes associated with passag…
  • College: College of Pharmacy
  • Inventors: Guo, Peixuan; Li, Hui; Wang, Shaoying
  • Licensing Officer: Flammang, Ann Marie

Automated analytical bioreactor for producing rare secondary metabolites
TS-039273 — A bioreactor that facilitates rapid and automatic (or semiautomatic) monitoring and measuring of rare biological and metabolic events.
A typical fermentor or bioreactor is designed to run batch processes and product information is gathered only at the end of the runs. In such a system, many intermediate metabolites or reaction products are not detected or monitored. Some of these intermediates could be valuable compounds produced…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Yousef, Ahmed; Kasler, David
  • Licensing Officer: Flammang, Ann Marie

Novel small peptide polarizing agents for dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) spectroscopy
TS-038322 — Versatile small biradical peptide molecules that can serve as biradical polarizing agents for dynamic nuclear polarization (DNP) solid-state nuclear magnetic resonance spectroscopy.
DNP methodology offers dramatic sensitivity enhancements of NMR experiments (up to 1-2 orders of magnitude) by transferring the large electron spin polarization to the nuclei of interest, and is currently one of the research frontiers in the magnetic resonance field with numerous applications to b…
  • College: College of Arts & Sciences
  • Inventors: Jaroniec, Christopher; Conroy, Daniel
  • Licensing Officer: Norris, Francis "Frank"

CXCR3-GFP knock-in mouse
TS-038221 — A knock-in murine model that expresses high levels of GFP in CXCR3 positive cells.
Chemokines are typically small, secreted molecules that participate in leukocyte trafficking, recruitment, and activation. They also play roles in normal and pathological processes including allergic responses, infectious and autoimmune disease, angiogenesis, inflammation, and tumor growth and met…
  • College: College of Arts & Sciences
  • Inventors: Satoskar, Abhay; Oghumu, Steve
  • Licensing Officer: Dahlman, Jason "Jay"

Methods for Making Three Dimensional Microfluidic Bioreactor Array
TS-037642 — Design for a three-dimensional microfluidic bioreactor array; device allows for culturing of a variety of cell types without contamination.
Cell culture in a three-dimensional fluidic-flow microenvironment is critical for long-term cell-based assays. Conducting in vitro research offers an accessible, reproducible, and reliable mode of investigation for therapeutic decisions before work is conducted in vivo. However, because of the com…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Wen, Yuan
  • Licensing Officer: Paschall, Christopher

Functionalization of Polymethylmethacrylate (PMMA) Surface by Amination with Polyethyleneimine (PEI) for Applications in Microfluidic Immunoassays, Protein/Enzyme Biochips, and Biocatalysis
TS-037631 — Polymethylmethacrylate (PMMA) is a useful material for development of assays, biochips, and other biological materials. However, PMMA makes for a difficult substrate because of complexities with respect to adhesion. This technology presents two new methods for enhanced protein binding onto PMMA.
Polymethylmethacrylate (PMMA) is a synthetic resin in the acrylic family, often used as a substitute for glass or as a material for biomedical devices. PMMA-based biosensors have low protein binding efficiency and low sensitivity. PMMA is used in a variety of applications like immunoassays, biosen…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Bai, Yunling
  • Licensing Officer: Paschall, Christopher

A Wearable Integrated System of Augmented Reality for Targeted Pathologic Specimen Sampling
TS-037535 — An integrated system to improve the quality of analysis of the resected tumor specimen that provides the pathologist with the latest technological and scientific advancements.
In the field of cancer pathology, the identification and sampling of tumors is essential for both surgical applications and treatment plans for patients that may include post-operative chemotherapy and/or radiation therapy. Currently pathologists and pathologist assistants rely on visual and tacti…
  • College: College of Engineering (COE)
  • Inventors: Yilmaz, Alper; Hall, Nathan; Hitchcock, Charles; Lee, Young Jin; Martin, Edward; Nichols, Shawnn; Ozer, Enver; Povoski, Stephen; Sachire, Jennifer; Xu, Ronald
  • Licensing Officer: Norris, Francis "Frank"

Bending Apparatus for Material Testing and Micro-CT Imaging
TS-037494 — A three-point bending device that can be used within a micro-CT scanner to record and analyze mechanical properties of bone and other material.
Conventional mechanical testing has been regarded as a gold standard for the evaluation of bone health. This testing typically requires compression, 3-point or 4-point bending, and torsional rotation of the bone utilizing conventional machines. Obtaining samples to test throughout a study requires…
  • College: College of Engineering (COE)
  • Inventors: Bodnyk, Kyle; Hart, Richard "Rich"; Litsky, Alan "Alan"
  • Licensing Officer: Norris, Francis "Frank"

Mouse Hybridoma BC25B11.2C Secreting Monoclonal Antibodies to Bovine Coronavirus
TS-037408 — A cloned mouse hybridoma cell line with potential use in diagnosis and treatment of bovine coronavirus (DB2 strain).
Bovine Coronavirus (BCV) - DB2 strain causes high death losses in young calves. Monoclonal antibodies produced in mice injected with hybridoma cells or concentrated hybridoma supernatant produced against bovine coronavirus- DB2 strain can be used to improve diagnostic tests, for possible therapy i…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Saif, Linda
  • Licensing Officer: Dahlman, Jason "Jay"

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