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Self-assembled 3D RNA Cage Nanoparticles with Precise Shape and Size for Applications in Medical Sciences, Materials Sciences, Engineering and Nanotechnology
TS-039545 — Self-assembling, highly stable RNA cages amenable to custom functionalization and cargo delivery
One of the primary challenges in therapeutic development is cheap, efficient, and safe drug delivery to specific target tissues. To better target specific tissues, RNA nanotechnology has been progressively applied to generate predefined architectures via self-assembly of modular building blocks. N…
  • College: College of Pharmacy
  • Inventors: Guo, Peixuan; Jasinski, Daniel; Khisamutdinov, Emil; Li, Hui
  • Licensing Officer: Flammang, Ann Marie

Dietary Carotenoid Assessment Tool (DCAT).
TS-038892 — A screening tool for rapid estimation of dietary carotenoid intake
The Need Diet is a major variable that contributes to human health and disease risk. Decades of scientific research suggest that dietary patterns rich in a variety of fruit and vegetables can reduce the risk of cancer through numerous mechanisms, however accurate dietary assessment remains challeng…
  • College: College of Medicine (COM)
  • Inventors: Clinton, Steven; Grainger, Elizabeth; Schmitz, Ashley; Simpson, Christina "Christi"; Thomas-Ahner, Jennifer
  • Licensing Officer: Flammang, Ann Marie

Methods for Making Three Dimensional Microfluidic Bioreactor Array
TS-037642 — Design for a three-dimensional microfluidic bioreactor array; device allows for culturing of a variety of cell types without contamination.
Cell culture in a three-dimensional fluidic-flow microenvironment is critical for long-term cell-based assays. Conducting in vitro research offers an accessible, reproducible, and reliable mode of investigation for therapeutic decisions before work is conducted in vivo. However, because of the com…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Wen, Yuan
  • Licensing Officer: Paschall, Christopher

Functionalization of Polymethylmethacrylate (PMMA) Surface by Amination with Polyethyleneimine (PEI) for Applications in Microfluidic Immunoassays, Protein/Enzyme Biochips, and Biocatalysis
TS-037631 — Polymethylmethacrylate (PMMA) is a useful material for development of assays, biochips, and other biological materials. However, PMMA makes for a difficult substrate because of complexities with respect to adhesion. This technology presents two new methods for enhanced protein binding onto PMMA.
Polymethylmethacrylate (PMMA) is a synthetic resin in the acrylic family, often used as a substitute for glass or as a material for biomedical devices. PMMA-based biosensors have low protein binding efficiency and low sensitivity. PMMA is used in a variety of applications like immunoassays, biosen…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Bai, Yunling
  • Licensing Officer: Paschall, Christopher

Mouse Hybridoma BC25B11.2C Secreting Monoclonal Antibodies to Bovine Coronavirus
TS-037408 — A cloned mouse hybridoma cell line with potential use in diagnosis and treatment of bovine coronavirus (DB2 strain).
Bovine Coronavirus (BCV) - DB2 strain causes high death losses in young calves. Monoclonal antibodies produced in mice injected with hybridoma cells or concentrated hybridoma supernatant produced against bovine coronavirus- DB2 strain can be used to improve diagnostic tests, for possible therapy i…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Saif, Linda
  • Licensing Officer: Dahlman, Jason "Jay"

Dose and Location Controlled Drug/Gene/Particle Delivery to Individual Cells by Nanoelectroporation
TS-037370 — A novel method to introduce targeted therapy to individual cells with perfect cell viability and transfection.
Precise delivery of nucleic acids is highly valuable for in vitro biomedical research, such as drug discovery, cell-drug biology, and cancer therapy. Controlled delivery of large gene molecules has the potential for highly efficient transfection of stem cells and pluripotent stem cells. However, c…
  • College: College of Engineering (COE)
  • Inventors: Lee, L; Boukany, Pouyan; Chiou, Nan-Rong; Guan, Jingjiao
  • Licensing Officer: Wohlgamuth, Christopher

Immortalized Duck Embryonic Intestinal Epithelial Cell line (MK-DIEC)
TS-036842 — An immortalized duck embryonic intestinal epithelial cell line (MK-DIEC) for producing live and killed vaccines
Currently most vaccine production is done through live embryonic eggs or primary cell cultures, allowing researchers to replicate pathogen function. Although existing vaccines for influenza and animal intestinal diseases such as porcine epidemic diarrhea virus (PEDV) exist and are considered effec…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Khatri, Mahesh
  • Licensing Officer: Dahlman, Jason "Jay"

Swine liver stem/progenitor cell line
TS-036771 — A spontaneously immortalized swine liver stem/progenitor cell line developed from normal White-Duroc crossbred pigs.
World-wide vaccine production is a multi-billion dollar industry. Currently, most vaccines are produced in live embryonated eggs or primary cell cultures. Vaccine production from eggs has been around for over half a century and can be costly and slow. Swine vaccine production from cell lines is of…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Khatri, Mahesh; Saif, Yehia
  • Licensing Officer: Dahlman, Jason "Jay"

Method for isolation of anthocyanin-mixtures from plant materials.
TS-036614 — A mixed-mode method for the isolation of anthocyanin-mixtures from plant materials.
Many biological studies currently rely on the extraction and fractionation of high purity pigments known as anthocyanins from fruits and vegetables, due to their ability to provide color and potential for increased health benefits. As a result of these benefits, anthocyanins have many applications…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Giusti, M. Monica "Monica"; Simmons, Steven
  • Licensing Officer: Flammang, Ann Marie

Automating the quantification of color space parameters from Visible Spectrum Absorbance
TS-036603 — Verbal communication of color is challenging, therefore mathematically-standardized color spaces are used. ColorBySpectra is software that in one click can convert large sets of absorbance data obtained from a simple spectrophotometer into color spaces: Hunter Lab, CIEL*c*h* and CIEL*a*b*. It reduces time for data collection, and sample volume and equipment needs. The software is useable on multiple platforms and would be useful in food science or other industries interested in precise color information.
There are several commonly used color spaces that quantify perceived color which include Hunter Lab, CIELab, and CIELch. To obtain these values, samples are usually presented to a colorimeter one sample at a time. Obtaining color data can be time consuming for many samples, and special equipment d…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Farr, Jacob; Giusti, M. Monica "Monica"
  • Licensing Officer: Flammang, Ann Marie

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