# of Displayed Technologies: 15 / 15

Applied Category Filter (Click To Remove): Research & Design Tools


Categories

RNA Nanotubes for Single Molecule Sensing and DNA/RNA/Protein Sequencing
TS-039514 — Stable, predictably ordered RNA nanopores for disease diagnosis and biopolymer sequencing.
New rapid and accurate sequencing methods, and disease detection methods are always in high demand. Newer advances in these areas include membrane-anchored structures and synthetics, which allow molecule idenfication and biopolymer sequencing by measuring conductance changes associated with passag…
  • College: College of Pharmacy
  • Inventors: Guo, Peixuan; Li, Hui; Wang, Shaoying
  • Licensing Officer: Flammang, Ann Marie

Novel Foam Collector for Bioreactors
TS-039273 — A foam collector to be used with bioreactors that would target and remove secondary metabolites produced and held within foam that is a product of the chemical reactions conducted.
Certain chemical reactions conducted in bioreactors, like aerobic fermentation, can produce a persistent foam that fills the headspace of the reactor vessels in which the reaction is taking place. This foam can be removed by introducing surface agents, but this is extremely undesirable as these ag…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Yousef, Ahmed; Kasler, David
  • Licensing Officer: Flammang, Ann Marie

Novel small peptide polarizing agents for dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) spectroscopy
TS-038322 — Versatile small biradical peptide molecules that can serve as biradical polarizing agents for dynamic nuclear polarization (DNP) solid-state nuclear magnetic resonance spectroscopy.
DNP methodology offers dramatic sensitivity enhancements of NMR experiments (up to 1-2 orders of magnitude) by transferring the large electron spin polarization to the nuclei of interest, and is currently one of the research frontiers in the magnetic resonance field with numerous applications to b…
  • College: College of Arts & Sciences
  • Inventors: Jaroniec, Christopher; Conroy, Daniel
  • Licensing Officer: Norris, Francis "Frank"

Methods for Making Three Dimensional Microfluidic Bioreactor Array
TS-037642 — Design for a three-dimensional microfluidic bioreactor array; device allows for culturing of a variety of cell types without contamination.
Cell culture in a three-dimensional fluidic-flow microenvironment is critical for long-term cell-based assays. Conducting in vitro research offers an accessible, reproducible, and reliable mode of investigation for therapeutic decisions before work is conducted in vivo. However, because of the com…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Wen, Yuan
  • Licensing Officer: Davis, Stewart

Functionalization of Polymethylmethacrylate (PMMA) Surface by Amination with Polyethyleneimine (PEI) for Applications in Microfluidic Immunoassays, Protein/Enzyme Biochips, and Biocatalysis
TS-037631 — Polymethylmethacrylate (PMMA) is a useful material for development of assays, biochips, and other biological materials. However, PMMA makes for a difficult substrate because of complexities with respect to adhesion. This technology presents two new methods for enhanced protein binding onto PMMA.
Polymethylmethacrylate (PMMA) is a synthetic resin in the acrylic family, often used as a substitute for glass or as a material for biomedical devices. PMMA-based biosensors have low protein binding efficiency and low sensitivity. PMMA is used in a variety of applications like immunoassays, biosen…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Bai, Yunling
  • Licensing Officer: Davis, Stewart

A Wearable Integrated System of Augmented Reality for Targeted Pathologic Specimen Sampling
TS-037535 — An integrated system to improve the quality of analysis of the resected tumor specimen that provides the pathologist with the latest technological and scientific advancements.
In the field of cancer pathology, the identification and sampling of tumors is essential for both surgical applications and treatment plans for patients that may include post-operative chemotherapy and/or radiation therapy. Currently pathologists and pathologist assistants rely on visual and tacti…
  • College: College of Engineering (COE)
  • Inventors: Yilmaz, Alper; Hall, Nathan; Hitchcock, Charles; Lee, Young Jin; Martin, Edward; Nichols, Shawnn; Ozer, Enver; Povoski, Stephen; Sachire, Jennifer; Xu, Ronald
  • Licensing Officer: Norris, Francis "Frank"

Bending Apparatus for Material Testing and Micro-CT Imaging
TS-037494 — A three-point bending device that can be used within a micro-CT scanner to record and analyze mechanical properties of bone and other material.
Conventional mechanical testing has been regarded as a gold standard for the evaluation of bone health. This testing typically requires compression, 3-point or 4-point bending, and torsional rotation of the bone utilizing conventional machines. Obtaining samples to test throughout a study requires…
  • College: College of Engineering (COE)
  • Inventors: Bodnyk, Kyle; Hart, Richard "Rich"; Litsky, Alan "Alan"
  • Licensing Officer: Norris, Francis "Frank"

Mouse Hybridoma BC25B11.2C Secreting Monoclonal Antibodies to Bovine Coronavirus
TS-037408 — A cloned mouse hybridoma cell line with potential use in diagnosis and treatment of bovine coronavirus (DB2 strain).
Bovine Coronavirus (BCV) - DB2 strain causes high death losses in young calves. Monoclonal antibodies produced in mice injected with hybridoma cells or concentrated hybridoma supernatant produced against bovine coronavirus- DB2 strain can be used to improve diagnostic tests, for possible therapy i…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Saif, Linda
  • Licensing Officer: Dahlman, Jason "Jay"

Mouse hybridoma 25C9.3C Secreting Monoclonal Antibodies to Porcine Coronavirus
TS-037407 — A cloned mouse hybridoma cell line
Transmissible gastroenteritis coronavirus (TGEV) is a porcine virus that has a mortality rate close to 100% in young pigs. Monoclonal antibodies produced in mice injected with hybridoma cells or concentrated hybridoma supernatant produced against porcine coronavirus-TGEV can be used to improve dia…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Saif, Linda
  • Licensing Officer: Dahlman, Jason "Jay"

Automating the quantification of color space parameters from Visible Spectrum Absorbance
TS-036603 — Verbal communication of color is challenging, therefore mathematically-standardized color spaces are used. ColorBySpectra is software that in one click can convert large sets of absorbance data obtained from a simple spectrophotometer into color spaces: Hunter Lab, CIEL*c*h* and CIEL*a*b*. It reduces time for data collection, and sample volume and equipment needs. The software is useable on multiple platforms and would be useful in food science or other industries interested in precise color information.
There are several commonly used color spaces that quantify perceived color which include Hunter Lab, CIELab, and CIELch. To obtain these values, samples are usually presented to a colorimeter one sample at a time. Obtaining color data can be time consuming for many samples, and special equipment d…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Farr, Jacob; Giusti, M. Monica "Monica"
  • Licensing Officer: Flammang, Ann Marie

Bioluminescent Clavibacter Michiganensis
TS-015169 — Bioluminescent Clavibacter michiganensis subspecies michiganensis (Cmm) strains are used as a tool for monitoring and developing disease control products for tomatoes
Currently, there are no tomato varieties that are resistant to Clavibacter michiganensis subspecies michiganensis (Cmm). Furthermore, Cmm-plant interactions are poorly understood. Developing an understanding of Cmm strains will allow growers to develop products that are highly active against this …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Miller, Sally; Rajashekara, Gireesh; Xu, Xiulan
  • Licensing Officer: Dahlman, Jason "Jay"

Monoclonal Antibody for Cereblon
TS-015144 — Highly specific and effective murine cereblon (CRBN) antibody for high quality immunoassays.
Cereblon (CRBN) is a 51 kDa protein encoded by the gene CRBN. This protein is a target of the immunomodulatory drugs thalidomide, lenalidomide, and pomalidomide that show substantial activity in several hematologic cancers, including multiple myeloma, acute myeloid leukemia, and chronic lymphocyti…
  • College: College of Medicine (COM)
  • Inventors: Lucas, David; Byrd, John
  • Licensing Officer: Davis, Stewart

Novel Spin Adduct for Free Radical Elimination
TS-015133 — 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO) as an improved cyclic spin trap, especially in mitigating superoxide radicals.
The linear PBN-type nitrones are limited by their ability to discern different radicals while the cyclic DMPO-type nitrones are limited by the stability of the adducts they form. Enolized DMPO-type spin adducts have been shown to dimerize and produce a six-line electron paramagnetic resonance (EPR…
  • College: College of Medicine (COM)
  • Inventors: Zweier, Jay; Hadad, Christopher; Villamena, Frederick
  • Licensing Officer: Davis, Stewart

Rapidly reversible DNA-quadruplex-based molecular capture system
TS-015081 — A specific and rapidly reversible system for single molecule capture employing magnesium-dependent DNA quadruplex structures.
Research and medical technology are increasingly dependent on single molecule capture and analysis. The current gold standard for non-covalent immobilization is streptavidin-biotin (STV-B). Although widely used, the biotin component in the interaction is resistant to dissociation, thus requiring h…
  • College: College of Arts & Sciences
  • Inventors: Kankia, Besik
  • Licensing Officer: Flammang, Ann Marie

Multichannel Polymer Chips for Rapid Multiplex Enzyme-Linked Immunosorbent Assay
TS-014978 — A more accurate, cost efficient and faster method to one of the most widely used diagnostic tests in the world.
The conventional Enzyme-Linked Immunosorbent Assay, or ELISA, is typically carried out in a 96-well or 384-well microliter plate. The method involves a series of mixing and washing steps, which are not only tedious and laborious, but which also often result in large errors and inconsistent outcome…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Bai, Yunling; Huang, Wei-Cho
  • Licensing Officer: Davis, Stewart

Loading icon