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Development of an E. coli strain for highthroughput screening of YidC inhibitors
TS-039359 — Development of a strain that is useful for screening compounds that inhibit YidC in E. coli and identification of compounds with antibacterial activity.
In bacteria, the YidC membrane protein functions in the insertation of proteins into the cytoplasmic membrane of E. coli. This protein is essential for life and is evolutionarily conserved. The rise of drug-resistant bacterial pathogens has created an urgent demand for novel antibiotic treatmen…
  • College: College of Arts & Sciences
  • Inventors: Dalbey, Ross
  • Licensing Officer: Paschall, Christopher

Methods for Making Three Dimensional Microfluidic Bioreactor Array
TS-037642 — Design for a three-dimensional microfluidic bioreactor array; device allows for culturing of a variety of cell types without contamination.
Cell culture in a three-dimensional fluidic-flow microenvironment is critical for long-term cell-based assays. Conducting in vitro research offers an accessible, reproducible, and reliable mode of investigation for therapeutic decisions before work is conducted in vivo. However, because of the com…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Wen, Yuan
  • Licensing Officer: Paschall, Christopher

Novel bacterial Type II topoisomerase inhibitors for the treatment of bacterial infections
TS-037293 — Bacterial infections such as sexually transmitted diseases, meningitis, pneumonia, tuberculosis (TB), and tetanus are some of the most common infectious diseases. However, there are few drugs that can be used against all of these diseases, and several bacteria have developed resistance to many com…
  • College: College of Pharmacy
  • Inventors: Mitton-Fry, Mark
  • Licensing Officer: Flammang, Ann Marie

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