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Engineering Calmodulin Proteins to Treat Ryanopathy-Associated Diseases
TS-032588 — Engineered calmodulin-based therapeutics for the treatment of cardiovascular diseases.
While there are three ryanodine receptors responsible for the release of calcium from intracellular stores during excitation-contraction, ryanodine receptor channel 2 (RyR2) has emerged as an important target in the treatment of cardiac failure. When RyR2 channels cease to effectively regulate int…
  • College: College of Medicine (COM)
  • Inventors: Davis, Jonathan
  • Licensing Officer: Paschall, Christopher
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