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Self-assembled 3D RNA Cage Nanoparticles with Precise Shape and Size for Applications in Medical Sciences, Materials Sciences, Engineering and Nanotechnology
TS-039545 — Self-assembling, highly stable RNA cages amenable to custom functionalization and cargo delivery
One of the primary challenges in therapeutic development is cheap, efficient, and safe drug delivery to specific target tissues. To better target specific tissues, RNA nanotechnology has been progressively applied to generate predefined architectures via self-assembly of modular building blocks. N…
  • College: College of Pharmacy
  • Inventors: Guo, Peixuan; Jasinski, Daniel; Khisamutdinov, Emil; Li, Hui
  • Licensing Officer: Flammang, Ann Marie

RNA Nanotubes for Single Molecule Sensing and DNA/RNA/Protein Sequencing
TS-039514 — Stable, predictably ordered RNA nanopores for disease diagnosis and biopolymer sequencing.
New rapid and accurate sequencing methods, and disease detection methods are always in high demand. Newer advances in these areas include membrane-anchored structures and synthetics, which allow molecule idenfication and biopolymer sequencing by measuring conductance changes associated with passag…
  • College: College of Pharmacy
  • Inventors: Guo, Peixuan; Li, Hui; Wang, Shaoying
  • Licensing Officer: Flammang, Ann Marie

Method for treatment of diseases of central nervous system (CNS) and improvement of cognitive function by nanoscaffolds
TS-038406 — A novel method to improve CNS metabolism and overall cognitive function as well as reduce peripheral neurodeneration, through the use of nanomatrices with or without identified redefined delivery biologicals and/or insulin.
The central nervous system (CNS) can be implicated in a broad category of diseases in which the brain does not function as expected. Conditions may result from a metabolic disorder; damage from an infection, a degenerative condition, stroke, a brain tumor or other problem; or arise from unknown or…
  • College: College of Arts & Sciences
  • Inventors: Ziouzenkova, Ouliana; Parquette, Jonathan
  • Licensing Officer: Flammang, Ann Marie

Lipid Nanoparticles for Therapeutic Delivery of Anti-miRs and miRs
TS-037707 — An efficient delivery vehicle for therapeutic oligonucleotides with high efficiency.
MiRNA or miRs are small non-protein coding RNA which are capable of regulating mRNAs in multiple biological pathways, including those involved in cancer development and wound healing. Antagomirs, also known as anti-miRs, inhibit miR activity and could be used to develop therapeutics for interventi…
  • College: College of Pharmacy
  • Inventors: Lee, Robert
  • Licensing Officer: Flammang, Ann Marie

Nanopump Separation Device and Method
TS-037584 — A device for separating macromolecules in a solution of macromolecules having different molecular sizes
Many clinical and research applications involve separation of specific biological molecules, such as nucleic acids and proteins, for further analysis and characterization. A complex biological system can only be understood after each component has been separately analyzed, and proteins must be pur…
  • College: College of Engineering (COE)
  • Inventors: Hansford, Derek; Walczak, Robbie
  • Licensing Officer: Smith, Richard

Method for Producing Epitaxial Semiconductor Nanowire Heterostructures on Metal Foil
TS-037409 — Semiconductor nanowire LEDs grown directly on flexible metal foil.
The formation of dislocations in conventional thin film devices due to lattice mismatch strain restricts the choice of substrate and heterointerface. Nanowires can accommodate large strains due to their surface to volume ratio that permits large lattice mismatched heterostructures without dislocat…
  • College: College of Engineering (COE)
  • Inventors: Myers, Roberto; May, Brelon; Sarwar, A.T.M. Golam
  • Licensing Officer: Wohlgamuth, Christopher

Nanoparticle and Long Fiber Reinforced Thermoset Nanocomposites
TS-037388 — A method to combine the advantages of both fiber reinforced plastics and polymer nanocomposites to produce a superior composite material.
Dispersion of nanoparticles into fiber reinforced plastics (FRPs) produces superior composites. Current methods face two problems: (1) best practices to disperse nanoparticles FRPs are not defined and (2) methods to maintain resin processability in the presence of nanoparticles are not understood.…
  • College: College of Engineering (COE)
  • Inventors: Lee, L James; Cao, Xia; Zhou, Gang
  • Licensing Officer: Wohlgamuth, Christopher

Synthesis and Foaming of Water Containing Activated Carbon-Nano/Microparticulate Polystyrene
TS-037386 — A novel method to increase thermal efficiency infrared absorption and bulk density of polystyrene foams.
Blowing agents create a cellular structure from a liquid plastic resin and, in certain cases, function as an insulating component of the foam. Hydrogen-containing chlorofluorocarbons and fluorocarbons are common blowing agents in the foam industry for extrusion forming of Polystyrene foam. However…
  • College: College of Engineering (COE)
  • Inventors: Lee, L James; Chiou, Nan-Rong; Yang, Jintao; Yeh, Shu Kai
  • Licensing Officer: Wohlgamuth, Christopher

Fabrication of Nanopapers and Nanoparticle Reinforced Polymeric Composites Using Vacuum-Assisted Layer-by-Layer Spraying Technique
TS-037364 — A method to combine advantages of fiber-reinforced plastics and nanocomposites to produce a low-cost, superior lightweight material.
Nanomaterials, more specifically nanoparticle reinforced composites, are one of the best solutions for most lightweight applications. Due to the dispersion and high aspect ratio of nanoparticles, lightweight polymer nanocomposites exhibit dimensional stability, heat and flame resistance, barrier p…
  • College: College of Engineering (COE)
  • Inventors: Lee, L James; Guerra, Dante; Min, Yong Gang; Movva, Siva
  • Licensing Officer: Wohlgamuth, Christopher

Porous Thermoelectric Materials
TS-037351 — A formulation to increase the efficiency of thermoelectric materials by reducing density.
Thermoelectric effects enable direct conversion of thermal to electrical energy, which provides an alternative power generation and temperature conditioning. Although thermoelectric systems are environmentally friendly, the efficiency of thermoelectric devices cannot compete with current gold-stan…
  • College: College of Engineering (COE)
  • Inventors: Heremans, Joseph; Jaworski, Christopher
  • Licensing Officer: Gooray, Arthur "Art"

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