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Nanoparticle Composition for Nucleic Acid Delivery
TS-044109 — Lipid nanoparticles (LNs) usable for the delivery of therapeutic compositions, including, but not limited to nucleic acids (NAs).
Nucleic Acid (NA) based therapies are used to inhibit gene expression. Lipid nanoparticles (LNs) are capable of carrying these therapies into cells. However, this delivery requires overcoming several physiological barriers. For instance, one barrier is the acidic endosome conditions within the cel…
  • College: College of Pharmacy
  • Inventors: Lee, Robert
  • Licensing Officer: Flammang, Ann Marie

RNA Nanotubes for Single Molecule Sensing and DNA/RNA/Protein Sequencing
TS-039514 — Stable, predictably ordered RNA nanopores for disease diagnosis and biopolymer sequencing.
New rapid and accurate sequencing methods, and disease detection methods are always in high demand. Newer advances in these areas include membrane-anchored structures and synthetics, which allow molecule idenfication and biopolymer sequencing by measuring conductance changes associated with passag…
  • College: College of Pharmacy
  • Inventors: Guo, Peixuan; Li, Hui; Wang, Shaoying
  • Licensing Officer: Flammang, Ann Marie

Nanopump Separation Device and Method
TS-037584 — A device for separating macromolecules in a solution of macromolecules having different molecular sizes
Many clinical and research applications involve separation of specific biological molecules, such as nucleic acids and proteins, for further analysis and characterization. A complex biological system can only be understood after each component has been separately analyzed, and proteins must be pur…
  • College: College of Engineering (COE)
  • Inventors: Hansford, Derek; Walczak, Robbie
  • Licensing Officer: Ezzell, Janel

Method for Oil–Water Separation Using Nanoparticles and Binder
TS-037436 — A coating which repels oil and attracts water, creating a highly efficient separation technique.
Across numerous industries, such as oil and natural gas processing, liquid-repellent surfaces are often essential to product development, or even operational sustainability via equipment maintenance. Current liquid repellents are optimized to protect against all liquids, including oil and water (s…
  • College: College of Engineering (COE)
  • Inventors: Martin, Samuel; Bhushan, Bharat; Brown, Philip
  • Licensing Officer: Norris, Francis "Frank"

Method for Repellency of Surfactant-Containing Liquids Using Nanoparticles and Binder
TS-037423 — A surface coating which repels both oil and water.
Materials with a coating that repels both water and oil would be advantageous across a wide variety of industries and products. Benefits of this kind of coating could include anti­fouling, self-cleaning, and anti­smudging capabilities. While modern clear coats and paints do offer protectio…
  • College: College of Engineering (COE)
  • Inventors: Martin, Samuel; Bhushan, Bharat
  • Licensing Officer: Norris, Francis "Frank"

Method for Producing Epitaxial Semiconductor Nanowire Heterostructures on Metal Foil
TS-037409 — Semiconductor nanowire LEDs grown directly on flexible metal foil.
The formation of dislocations in conventional thin film devices due to lattice mismatch strain restricts the choice of substrate and heterointerface. Nanowires can accommodate large strains due to their surface to volume ratio that permits large lattice mismatched heterostructures without dislocat…
  • College: College of Engineering (COE)
  • Inventors: Myers, Roberto; May, Brelon; Sarwar, A.T.M. Golam
  • Licensing Officer: Hong, Dongsung

Nanoparticle and Long Fiber Reinforced Thermoset Nanocomposites
TS-037388 — A method to combine the advantages of both fiber reinforced plastics and polymer nanocomposites to produce a superior composite material.
Dispersion of nanoparticles into fiber reinforced plastics (FRPs) produces superior composites. Current methods face two problems: (1) best practices to disperse nanoparticles FRPs are not defined and (2) methods to maintain resin processability in the presence of nanoparticles are not understood.…
  • College: College of Engineering (COE)
  • Inventors: Lee, L James; Cao, Xia; Zhou, Gang
  • Licensing Officer: Norris, Francis "Frank"

Synthesis and Foaming of Water Containing Activated Carbon-Nano/Microparticulate Polystyrene
TS-037386 — A novel method to increase thermal efficiency infrared absorption and bulk density of polystyrene foams.
Blowing agents create a cellular structure from a liquid plastic resin and, in certain cases, function as an insulating component of the foam. Hydrogen-containing chlorofluorocarbons and fluorocarbons are common blowing agents in the foam industry for extrusion forming of Polystyrene foam. However…
  • College: College of Engineering (COE)
  • Inventors: Lee, L James; Chiou, Nan-Rong; Yang, Jintao; Yeh, Shu Kai
  • Licensing Officer: Norris, Francis "Frank"

Fabrication of Nanopapers and Nanoparticle Reinforced Polymeric Composites Using Vacuum-Assisted Layer-by-Layer Spraying Technique
TS-037364 — A method to combine advantages of fiber-reinforced plastics and nanocomposites to produce a low-cost, superior lightweight material.
Nanomaterials, more specifically nanoparticle reinforced composites, are one of the best solutions for most lightweight applications. Due to the dispersion and high aspect ratio of nanoparticles, lightweight polymer nanocomposites exhibit dimensional stability, heat and flame resistance, barrier p…
  • College: College of Engineering (COE)
  • Inventors: Lee, L James; Guerra, Dante; Min, Yong Gang; Movva, Siva
  • Licensing Officer: Norris, Francis "Frank"

Porous Thermoelectric Materials
TS-037351 — A formulation to increase the efficiency of thermoelectric materials by reducing density.
Thermoelectric effects enable direct conversion of thermal to electrical energy, which provides an alternative power generation and temperature conditioning. Although thermoelectric systems are environmentally friendly, the efficiency of thermoelectric devices cannot compete with current gold-stan…
  • College: College of Engineering (COE)
  • Inventors: Heremans, Joseph; Jaworski, Christopher
  • Licensing Officer: Gooray, Arthur "Art"

Method to Synthesize Ceratamine A and B and Analogs Thereof
TS-030264 — A chemical process to produce ceratamine A and B.
The natural products ceratamines A and B were isolated from a marine sponge in minute quantities and shown to have potent anti-tumor activity. Due to the insufficient sample size and subsequent lack of availability of the producing sponge, evaluation was incomplete. Thus, the clinical potential ne…
  • College: College of Arts & Sciences
  • Inventors: Coleman, Robert "Rob"; Campbell, Erica
  • Licensing Officer: Davis, Stewart

Carbide bonded Graphene Coating
TS-015271 — A facile approach for obtaining carbide-bonded graphene coatings on a variety of metallic and nonmetallic substrates.
Despite the many attractive features of graphene, the lack of atomic bonds between graphene and substrates and among graphene nanosheets has limited its potential applications. Although theoretical considerations predict that covalent bonds between graphene nanosheets would significantly improve s…
  • College: College of Engineering (COE)
  • Inventors: Lee, L James; Huang, Wenyi; Yu, Jianfeng
  • Licensing Officer: Norris, Francis "Frank"

Zeolite/Polymer Composite Membranes for Carbon Dioxide Separations
TS-015156 — Zeolite/polymer composite membranes for carbon dioxide separations
The energy and environmental markets are producing a great research and development race to improve membranes for the fuel cell market to replace petroleum-based energy sources, to improve hydrogen production for use as a fuel in vehicles, and to sequester carbon dioxide to reduce the greenhouse e…
  • College: College of Engineering (COE)
  • Inventors: Ho, W.S. Winston; Dutta, Prabir; Ramasubramanian, Kartik; Severance, Michael
  • Licensing Officer: Bartell, Cordellia

Stable Supported Pd-alloy Membranes
TS-015105 — A Pd-alloy membrane filter for hydrogen (H2) gas with improved strength and performance
Supported Pd-alloy membranes separate hydrogen from gas mixtures and enable hydrogen as an energy carrier. However, the dense Pd-alloy (PdA) structure only allows hydrogen gas to pass in the form of interstitial H atoms, which inhibits transfer of other gases through the membrane. Selective remova…
  • College: College of Engineering (COE)
  • Inventors: Verweij, Hendrik; Shqau, Krenar
  • Licensing Officer: Bartell, Cordellia

Electrospun Nano-fiber Plates for Chromatography and Solid Phase Micro-extraction
TS-014955 — Ultra-thin layer chromatography plates that offer faster and more efficient separation of compound mixtures
Both thin layer chromatography (TLC) and ultra-thin layer chromatography (UTLC) plates are used widely in academia and industry to identify separate compounds in a mixture. However, there exists little variety in existing plates available, which limits researchers when identifying compounds quickl…
  • College: College of Arts & Sciences
  • Inventors: Olesik, Susan; Steach, Jeremy
  • Licensing Officer: Bartell, Cordellia

Efficient Graded III-Nitride Nanowires
TS-014952 — A nanowire that overcomes defect formation normally found in LEDs, leading to higher charge density.
Unlike traditional light bulbs, Light Emitting Diodes (LEDs) use less power, last longer, and contain no environmentally harmful substances. However, LEDs struggle with technical errors, such as lattice mismatch and large resistances. As adoption increases, it is necessary to develop LEDs that are…
  • College: College of Engineering (COE)
  • Inventors: Rajan, Siddharth; Myers, Roberto
  • Licensing Officer: Hong, Dongsung

Electrochemical Method for LiFeAs Superconductor
TS-014875 — Electrochemical method for LiFeAs superconductor preparation suitable for large scale production.
LiFeAs compounds, compared to FeAs materials, do not demonstrate spin-density wave behavior and exhibit superconductivity at ambient pressures without chemical doping. However, the current electrochemical methods to prepare pnictide LiFeAs superconductors require a solid-state reaction at high tem…
  • College: College of Engineering (COE)
  • Inventors: Majoros, Milan; Collings, Edward; Kanuchova, Maria; Sumption, Michael
  • Licensing Officer: Bartell, Cordellia

Germanium Graphane Semiconductor
TS-014847 — A germanium substituted graphane and a methylated derivative for use as a novel semiconductor.
Two-Dimensional van der Waals materials have shown great promise for a variety of electronic, optoelectronic, sensing, and energy conversion applications. To meet the need for clean energy production, photovoltaic cells and thermoelectric modules require advanced semiconducting materials that incr…
  • College: College of Arts & Sciences
  • Inventors: Goldberger, Joshua; Bianco, Elizabeth; Jiang, Shishi
  • Licensing Officer: Bartell, Cordellia

Self-Assembly of Therapeutic-Agent Nanostructures
TS-014812 — An improved delivery mechanism has been developed for hydrophobic drugs such as camptothecin which will increase chemotherapeutic efficacy.
Many cancer therapeutics exhibit extremely toxic side effects or have limited efficacy due to low bio-availability. Existing drug delivery technologies can add excessive mass to the therapeutic, grossly expanding the dosage necessary for response. Camptothecin (CPT) is a naturally occurring compou…
  • College: College of Arts & Sciences
  • Inventors: Parquette, Jonathan; Grinstaff, Mark; Kaplan, Jonah; Kim, Se Hye
  • Licensing Officer: Flammang, Ann Marie

High Surface Area Catalysts for Fuel Cells
TS-014755 — A high performance and durable reductive catalyst for polymer and metal-air fuel cells
Fuel cells offer a cleaner, more-efficient alternative to gasoline and other fossil fuels, and have the potential to revolutionize the way the nation is powered. Fuel cells operate in a similar fashion to conventional batteries, but fuel cells can be continually supplied with a fresh feed of fuel,…
  • College: College of Arts & Sciences
  • Inventors: Co, Anne; Coleman, Eric
  • Licensing Officer: Bartell, Cordellia

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