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Treatment of Multiple Sclerosis with small molecule IL-6/STAT3 inhibitors
TS-038701 — Small-molecule prodrugs that target IL-6/STAT3 signaling pathway.
Multiple Sclerosis (MS), an unpredictable and disabling autoimmune disease affecting the central nervous system, is the leading cause of non-traumatic neurological disability in young adults. There have been important advances in MS therapy, such as drugs that slow the progression of the disease a…
  • College: College of Medicine (COM)
  • Inventors: Yang, Yuhong; Li, Chenglong; Racke, Michael
  • Licensing Officer: Flammang, Ann Marie

Novel Use of Fostamatinib as a Therapeutic for Liver Cancer, both as First-Line Therapy and Following Acquired Resistance to Sorafenib
TS-032418 — A combination-therapy that has the potential to overcome and/or prevent the commonly observed acquisition of sorafenib resistance, which is associated with treatment failure in patients with hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) kills nearly all patients within a year of diagnosis, and results in between 250,000 and one million deaths globally per year. In the US, incidences of HCC have nearly tripled in the past 30 years and currently remain one of the fastest growing causes of cancer-relat…
  • College: College of Medicine (COM)
  • Inventors: Motiwala, Tasneem; Regan, Kelly; Reyes, Ryan
  • Licensing Officer: Flammang, Ann Marie

Small Molecule Modulators as a Means to Control Tomato Bacterial Canker
TS-014936 — Small molecule modulators of Clavibacter michiganensis subsp. michiganensis (Cmm) as a means to control tomatobacterial canker.
Current efforts to control tomato cankers rely heavily on copper bactericides and antibiotics. These methods have significant limitations in that they exhibit limited efficacy in treatment and may promote pathogen resistance. Common strategies for controlling tomato bacterial canker mainly rely on…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rajashekara, Gireesh; Fuchs, James; Miller, Sally; Nislow, Corey; Xu, Xiulan
  • Licensing Officer: Dahlman, Jason "Jay"
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