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Live vaccine candidate for Chagas disease
TS-044084 — Trypanosoma cruzi is a protozoan parasite that causes Chagas disease, a PRV-eligible disease that is the leading cause of heart failure in Latin America. Due to migration of infected hosts from endemic regions, Chagas disease is also a growing public health concern in the USA and other migrant des…
  • College: College of Medicine (COM)
  • Inventors: McGwire, Bradford
  • Licensing Officer: Dahlman, Jason "Jay"

A Novel Vectored Vaccine Against Human Norovirus
TS-037664 — A live recombinant vesicular stomatitis virus (VSV)-vector vaccine composition for human norovirus.
Human norovirus (HuNoV) is a major causative agent of foodborne gastroenteritis worldwide. It is estimated that over 90% of outbreaks of acute nonbacterial gastroenteritis are caused by noroviruses. Healthcare facilities, including nursing homes and hospitals, are the most commonly reported place …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Li, Jianrong; Ma, Yuanmei
  • Licensing Officer: Dahlman, Jason "Jay"

Selective Delipidation of Mycobacterium bovis BCG enhances its Vaccine Potential against TB
TS-037463 — A novel method to increase vaccine effectiveness for TB
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), is an infectious disease that kills one person every 21 seconds. TB is the current leading cause of death worldwide due to a single infectious organism, overtaking AIDS and malaria. TB treatment requires several months to years of che…
  • College: College of Medicine (COM)
  • Inventors: Torrelles, Jordi; Moliva, Juan
  • Licensing Officer: Norris, Francis "Frank"

Novel Vaccine for Respiratory Syncytial Virus
TS-037299 — Recombinant vesicular stomatitis virus (rVSV) vaccines to fight against respiratory syncytial virus (RSV) infections.
Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory tract illness (ALRI) in infants, children, and the elderly, and often leads to fatal bronchiolitis and pneumonia. About 3.4 million children under the age of five are hospitalized each year due to an acute RSV in…
  • College: College of Veterinary Medicine
  • Inventors: Niewiesk, Stefan; Binjawadagi, Basavaraj; Li, Jianrong; Peeples, Mark
  • Licensing Officer: Dahlman, Jason "Jay"

Methods to Improve Mucosal Immune Response During Vaccination
TS-015239 — A method for enhancing the mucosal (IgA) immune response by transiently blocking a specific cellular subset during vaccination.
Mucosal IgA are immunoglobulins (antibodies) that play a key role in the defense of mucosal tissues by neutralizing pathogenic microorganisms and toxins and interfering with bacterial or viral colonization of the epithelium. An important component of needle-free vaccines is induction of mucosal Ig…
  • College: College of Veterinary Medicine
  • Inventors: Boyaka, Prosper
  • Licensing Officer: Dahlman, Jason "Jay"

Silvestrol as an Immune Adjuvant for Vaccines
TS-014782 — Silvestrol promotes the prevention and treatment of various cancers as an immune adjuvant.
Molecular changes due to malignant tumors and toxicity of chemotherapeutic regimen suppress the immune system of cancer patients. This immunosuppression also leaves patients vulnerable to opportunistic infections and reactivation of latent viral or mycobacterial infections. Immunostimulation, or a…
  • College: College of Medicine (COM)
  • Inventors: Baiocchi, Robert; Grever, Michael; Kinghorn, Alan "Dr. A. Douglas Kinghorn"; Lucas, David; Patton, John
  • Licensing Officer: Ezzell, Janel

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