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Targeted Nanobody Technology for Precise Antineoplastic Treatment
TS-065460 — The Need Cancer remains one of the most pressing medical challenges worldwide, necessitating novel therapeutic approaches to combat its proliferation. Despite advancements, targeted therapies are often limited by immune responses or cumbersome production processes. There's a growing demand for …
  • College: College of Arts & Sciences
  • Inventors: Magliery, Thomas; Palmieri, Dario; Ryan-Simkins, Michael
  • Licensing Officer: Willson, Christopher

Peptide-based inhibitor of host factor involved in HIV-1 replication
TS-065459 — The Need The emergence of HIV-1 infection continues to pose significant challenges in healthcare worldwide. Current treatment approaches primarily target viral components, leading to the development of drug resistance over time. There is a pressing need for innovative therapeutic strategies that di…
  • College: College of Arts & Sciences
  • Inventors: Musier-Forsyth, Karin; Tang, Yingke
  • Licensing Officer: Willson, Christopher

Precision RNA-PROTACs: Revolutionizing Therapeutic Targeting of Dysregulated Ribonucleoprotein Complexes
TS-065457 — The Need: In the realm of therapeutic development, there's a pressing need for precise targeting of dysregulated ribonucleoprotein (RNP) complexes to combat various diseases, particularly neurodegenerative disorders like ALS, Alzheimer’s, and Huntington’s diseases. Traditional metho…
  • College: College of Arts & Sciences
  • Inventors: Bong, Dennis; Liang, Yufeng; Miao, Shiqin "Shiqin"; Strong, Rebekah
  • Licensing Officer: Willson, Christopher

MicroRNA profile predicts colon cancer prognosis
TS-065453 — The Need: Colon cancer remains one of the most prevalent and lethal forms of cancer worldwide. Timely and accurate diagnosis is critical for effective treatment and improved patient outcomes. Current diagnostic methods often lack the precision and sensitivity needed for early detection and prognosi…
  • College: College of Medicine (COM)
  • Inventors: Croce, Carlo
  • Licensing Officer: Dahlman, Jason "Jay"

Containment System for Heating and Off-Gassing
TS-065424 — Due to environmental concerns and the decreasing supply of fossil fuels, there is substantial demand for nuclear-based energy production. Nuclear energy now provides about 10% of the world's electricity from about 440 power reactors and is the second largest source of low-carbon power. In addition, over 50 smaller countries utilize nuclear energy in about 220 research-size reactors. These reactors are used to produce medical and industrial isotopes and several other purposes.
It is essential to meet the safeguard requirements in liquid-fueled molten salt reactors, fuel salt transportation, and fuel cycle processes and to develop effective methods for measuring and monitoring the mass of molten fuel salt or coolant salt. However, due to the complex and dynamic nature o…
  • College: College of Engineering (COE)
  • Inventors: Van Zile, Matthew; Cao, Lei Raymond; Kauffman, Andrew
  • Licensing Officer: Zinn, Ryan

Enhancing Antibody Therapies Using a NOD2 Agonist
TS-065320 — Stimulating monocytes with a NOD2 agonist increases effectiveness of monoclonal antibody therapy.
An estimated 20,160 new cases of chronic lymphocytic leukemia (CLL) and 4,410 deaths were expected in 2022. Current therapies for CLL include the administration of a monoclonal antibody, such as rituximab, an anti-CD20 antibody, to promote clearance of malignant B cells. The Need Current therapies…
  • College: College of Medicine (COM)
  • Inventors: Tridandapani, Susheela; Butchar, Jonathan; Mehta, Payal; Merchand Reyes, Giovanna; Santhanam, Ramasamy
  • Licensing Officer: Schultz, Teri

Novel Extracellular Vesicles Loaded with Anti-Inflammatory Agents
TS-065154 — Revolutionary treatment for ARDS using novel extracellular vesicles loaded with Anti-Inflammatory Agents.
The Need Acute Respiratory Distress Syndrome (ARDS) remains a significant healthcare challenge with high mortality rates and long-term morbidity. Despite advancements in supportive care, there’s an urgent need for pharmacologic treatments targeting the molecular mechanisms driving ARDS pathog…
  • College: College of Medicine (COM)
  • Inventors: Karpurapu, Manjula; Christman, John; Parinandi, Narasimham
  • Licensing Officer: Schultz, Teri

Combination B Cell Epitope Vaccines for Cancer Treatment
TS-064843 — , T2022-244, T2020-109 : Cancer vaccines targeting a combination of B Cell epitopes to improve patient outcomes.
The Need Despite the clinical success of checkpoint receptor blockade in various cancer subtypes, many patients develop resistance, presenting a pressing need for novel approaches. Current inhibitors, like PD-1/PD-L1 and HER-2 exhibit limited efficacy and significant toxicities, underscoring the d…
  • College: College of Medicine (COM)
  • Inventors: Kaumaya, Pravin
  • Licensing Officer: Schultz, Teri

IR Precision: Revolutionizing Colorectal Cancer Metastasis Diagnosis with the CCML Library
TS-064834 — The Need: Colorectal cancer remains a significant global health challenge, particularly when it metastasizes to the liver. Accurate and rapid diagnosis of metastatic liver lesions is crucial for effective treatment planning and patient outcomes. Traditional diagnostic methods often lack the specific…
  • College: College of Arts & Sciences
  • Inventors: Coe, James; Allen, Heather; Bradley, Rebecca; Hitchcock, Charles; Martin, Edward
  • Licensing Officer: Willson, Christopher

Decision Support Tool for Prevention of Failure to Rescue Events
TS-064718 — A clinical decision support tool for minimizing failure to rescue events at hospitals.
Failure to rescue (FTR) is a serious issue in patient safety and healthcare quality for hospitalized patients. The term implies that rescue is possible, and death is, therefore, a failure. On any given day across the country, two-thirds of deaths in hospitals could be judged as preventable. In 2005,…
  • College: OSU Wexner Medical Center
  • Inventors: Garvey, Paula; Justice, Stephanie
  • Licensing Officer: Schultz, Teri

Intracellular Targeting by Monoclonal Antibodies
TS-064581 — Antibodies are essential therapeutic modalities for treating a plethora of different diseases, ranging from cancer, autoimmune disorders, degenerative diseases, and inflammation. The FDA approved the first antibody over three decades ago, and since more than 570 have been studied in clinical trials,…
  • College: College of Arts & Sciences
  • Inventors: Magliery, Thomas; Do, Jamie; Han, Jeong Min "Mina"; Zhu, Ian
  • Licensing Officer: Willson, Christopher

Magnetic Nanoparticles for Cancer Cell Classification
TS-064577 — Glioblastoma (GBM) is the most common malignant brain tumor accounting for 47.7% of all brain cancers. Unfortunately, treatments are limited, and survival is poor, with approximately only 40% living past the first-year post-diagnosis and 17% in the second year. The Need Developing drugs for cance…
  • College: College of Arts & Sciences
  • Inventors: Schultz, Zachary; Rist, David; Skardal, Aleksander; Venere, Monica
  • Licensing Officer: Willson, Christopher

Utilizing WT-IV-012 to improve immune checkpoint therapy in cancer treatment
TS-064262 — The Need Addressing the limitations of current melanoma therapies, there exists a critical need for innovative approaches that enhance the effectiveness of immune checkpoint therapeutics. Despite advancements in immunotherapy, a significant percentage of melanoma patients do not achieve complete re…
  • College: College of Arts & Sciences
  • Inventors: Burd, Craig; Aguilar-Valenzuela, Renan; Burd, Christin
  • Licensing Officer: Willson, Christopher

Multimeric Notch ligands based on IgM-like fusion molecular structures for activation of ligand-specific Notch signaling
TS-064248 — The Notch signaling pathway is important in immune cell differentiation and maturation. As a result, it has been shown that Notch receptor signaling can promote or suppress adaptive immune responses depending on the particular ligands and receptors involved. A set of native protein-inspired biolog…
  • College: OSU Wexner Medical Center
  • Inventors: Dikov, Mikhail; Carbone, David; Goruganthu, Uttam Lakshmi Mounika; Tchekneva, Elena
  • Licensing Officer: Willson, Christopher

CDP-choline a host-directed therapeutic for disease caused by SARS CoV-2 infection.
TS-064192 — The Need: The global impact of the SARS CoV-2 coronavirus has created an urgent need for innovative medical interventions to address the challenges posed by COVID-19. Despite the availability of vaccines, sub-optimal vaccine uptake and concerns about new virus variants necessitate additional medical…
  • College: College of Veterinary Medicine
  • Inventors: Davis, Ian; Schelhorn, Jean
  • Licensing Officer: Dahlman, Jason "Jay"

Introducing HexaPro VSV: A Breakthrough in COVID-19 Vaccine Technology
TS-064191 — The emergence of SARS-CoV-2 variants poses a significant challenge to existing COVID-19 vaccines, necessitating the development of a more durable and broadly protective solution. Current vaccines show reduced efficacy over time and struggle against Variants of Concern (VoCs) such as Omicron. Addre…
  • College: College of Veterinary Medicine
  • Inventors: Li, Jianrong; Chamblee, Michelle; Lu, Mijia; Zhang, Yuexiu
  • Licensing Officer: Dahlman, Jason "Jay"

A next generation intranasal trivalent Measles, Mumps and Covid vaccine
TS-064189 — The Need The current global landscape demands innovative solutions to address the urgent need for a safe and efficacious SARS-CoV-2 vaccine, particularly for the vulnerable population of infants and children under 12 years old. Existing vaccines face challenges in terms of durability, cost, and sta…
  • College: College of Veterinary Medicine
  • Inventors: Li, Jianrong; Xu, Jiayu; Zhang, Yuexiu
  • Licensing Officer: Dahlman, Jason "Jay"

Small molecules that suppress heat/pain perception
TS-064187 — The Need In the culinary and pharmaceutical realms, the need for a groundbreaking solution to modulate flavor and alleviate sensory perceptions is crucial. Businesses seek innovative ways to enhance consumer experiences by addressing pungency in foods and alleviating burn or pain sensations in phar…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Peterson, Devin; borcherding, Joel
  • Licensing Officer: Dahlman, Jason "Jay"

Scalable Nanoparticle Synthesis for Precision Applications
TS-064181 — In the rapidly evolving landscape of nanotechnology, there exists a critical demand for scalable and efficient methods of producing nanoparticles. Current approaches, often confined to small-scale batches, hinder the widespread implementation of nanomaterials in diverse fields such as medicine, bi…
  • College: College of Engineering (COE)
  • Inventors: Winter, Jessica; Ruan, Gang
  • Licensing Officer: Dahlman, Jason "Jay"

Unveiling Biochemically Responsive MR Probes for Precision Beyond Limits
TS-064179 — In the realm of medical diagnostics, the need for precise and non-invasive detection of molecular-level pathology has been a longstanding challenge. Traditional imaging techniques often fall short in providing detailed insights into biological processes at this scale. To address this gap, there is…
  • College: College of Arts & Sciences
  • Inventors: Shafaat, Hannah "Hannah"
  • Licensing Officer: Dahlman, Jason "Jay"

A new diagnostic assay for classic galactosemia
TS-064133 — Classic galactosemia is a genetic condition that can lead to life-threatening complications, including feeding problems, failure to thrive, liver damage, bleeding, and sepsis. If a lactose-restricted diet is provided during the first ten days of life, the neonatal symptoms quickly resolve and reduce…
  • College: College of Arts & Sciences
  • Inventors: Gopalan, Venkat; Bashian, Eleanor; Thirugnanasambantham, Pankajavalli
  • Licensing Officer: Willson, Christopher

Skin Healing Technology: Dermal Substitutes and Engineered Skin with Rete Ridges
TS-064046 — Dermal substitute with engineered rete ridges improves epidermal-dermal communication and enhances burn wound treatment.
Massive burn injuries present a critical challenge in wound healing and prevention of infection. Current treatment methods are susceptible to blistering and other problems that can reduce engraftment. The Need Cultured epithelial autografts (CEAs) are a vital component in treating large burns, but…
  • College: College of Engineering (COE)
  • Inventors: Powell, Heather; Bailey, John; Blackstone, Britani "Niki"
  • Licensing Officer: Schultz, Teri

Automated Plant DNA Extraction for Portable Genomic Sequencing
TS-063963 — The Need In the dynamic realm of space exploration, the imperative to sustain life during extended missions places a critical demand on understanding the impact of spaceflight on plant growth. Traditional DNA sequencing methods employed by NASA fall short when dealing with plant material, necessita…
  • College: College of Engineering (COE)
  • Inventors: Brozovich, Cassidy; Ling, Peter; Tkach, Chris
  • Licensing Officer: Randhawa, Davinder

Adjustable Squatting Device for Constipation
TS-063959 — The Need Millions of individuals suffer from constipation due to the inability to relax pelvic floor muscles during bowel movements, leading to discomfort and strained efforts. Current solutions, like the Squatty Potty, lack adjustability and portability, limiting their effectiveness for a diverse …
  • College: College of Engineering (COE)
  • Inventors: Ruegsegger, Mark; Chakraborty, Subhankar; Gluzman, Isabella; Li, Yiqun; Piatkowski, Stephen; Puri, Raima
  • Licensing Officer: Bhatti, Hamid

Endoscopic additive manufacturing of biomaterials
TS-063919 — An articulating end effector for additive manufacturing that utilizes robot-assisted endoscopic surgery to implant synthetic tissues at local defects through “keyhole” incisions in patients. This innovative technology T2019-145 is part of a portfolio that also includes T2017-363. To learn more about both technologies, please visit https://oied.osu.edu/find-technologies and search using the phrase: Endoscopic additive manufacturing of biomaterials.
Robot-assisted surgery, tissue engineering, and additive manufacturing (AM) are emerging techniques in healthcare. Currently AM is used to develop synthetic tissues and organs, but open surgery is typically used to implant these scaffolds within the patient. This invasive procedure can subject pat…
  • College: College of Engineering (COE)
  • Inventors: Hoelzle, David; Asghari Adib, Ali; D'Souza, Desmond; Mansour, Daniel; Simeunovic, Andrej
  • Licensing Officer: Zinn, Ryan

Novel STK1-targeted small molecule "antibiotic resistance breaker" compounds
TS-063547 — Novel small molecule STK1 inhibitors that “break” the resistance of bacteria strains to antibiotics.
In today’s healthcare landscape, increasingly highly pathogenic and multidrug-resistant S. aureus (MDRSA) strains are replacing traditional methicillin-resistant S. aureus (MRSA) in both community and hospital settings. The Need The rise of these resilient multi-drug resistant bacteria has …
  • College: College of Medicine (COM)
  • Inventors: Pancholi, Vijay
  • Licensing Officer: Schultz, Teri

High-K Dielectric barriers to suppress internal photoemission photocurrents
TS-063471 — In an increasingly digital world, the demand for efficient and reliable photodetectors is paramount. These devices are critical for a variety of applications, from medical imaging to defense systems. However, traditional photodetectors often struggle with low UV-visible rejection, limiting their e…
  • College: College of Engineering (COE)
  • Inventors: Rajan, Siddharth; McGlone, Joseph "Joe"; Wriedt, Nathan
  • Licensing Officer: Zinn, Ryan

Protecting the vascular endothelial barrier – a novel approach to treating atrial fibrillation
TS-063433 — A new pharmacologic modality for treating AFib.
Atrial fibrillation (AF) is the most common form of irregular cardiac rhythm (arrhythmia), affecting approximately 3% of the US population. It is a significant risk factor for heart failure, ischemic stroke, and sudden cardiac death. The AF mortality rate is growing globally, and risk factors known …
  • College: College of Engineering (COE)
  • Inventors: Veeraraghavan, Rengasayee; Mezache, Louisa
  • Licensing Officer: Schultz, Teri

A Regularized Conditional GAN for Posterior Sampling in Inverse Problems
TS-063238 — A novel regularization technique applicable for medical imaging applications that leverages conditional generative adversarial networks (cGANs) to generate reconstructed images in significantly shorter timeframes. The Need Several techniques are used for image reconstruction in the medical aren…
  • College: College of Engineering (COE)
  • Inventors: Bendel, Matthew; Ahmad, Rizwan; Schniter, Philip
  • Licensing Officer: Hampton, Andrew

Hybrid Collaborative Filtering Methods for Recommending Search Terms to Clinicians
TS-063237 — Electronic Health Records (EHR) are used in over 88% of all US medical clinics to improve care and streamline data. In addition, they enable sharing of data to multiple providers dealing with the same patient, thereby enhancing efficiency and care. The Need In the last decade, medical practices…
  • College: College of Medicine (COM)
  • Inventors: Ning, Xia; Peng, Bo; Ren, Zhiyun
  • Licensing Officer: Hampton, Andrew

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