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Compact Cas9-based transcriptional regulators for in vivo gene regulation
TS-045681 — Cas9-derived constructs can be used to modulate gene expression, but physical limitations restrict the application of this technique. Researchers at The Ohio State University have overcome this obstacle by engineering new Cas9-derived transcription factors.
CRISPR/Cas9 systems have revolutionized the field of programmable DNA technology. Recently, a version of the Cas9 protein with a deactivated nuclease domain called “dCas9” was developed. Without this domain, dCas9’s range of activity is limited to recognizing and binding sequence…
  • College: College of Medicine (COM)
  • Inventors: Han, Renzhi; Gao, Yandi; Xu, Li
  • Licensing Officer: Dahlman, Jason "Jay"

Gene delivery to adipose tissue using novel recombinant adeno-associated viral vectors
TS-037310 — An engineered recombinant adeno-associated virus capable of targeting fat tissue previously inaccessible to this viral vector for the purposes of genetic manipulation.
Recombinant adeno-associated viruses (rAAVs) have been effective tools for delivering gene therapy treatment and for manipulation of acquired diseases. Unfortunately, there is no effective method to target gene therapy for adipose tissue and transduction efficiency is low in naturally occuring AAV…
  • College: College of Medicine (COM)
  • Inventors: Cao, Lei; Huang, Wei
  • Licensing Officer: Ezzell, Janel

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