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Enhancing the mechanical performance of resistance spot welding of aluminum alloys to steel using chromium-rich Interlayers
TS-054040 — This is a new method of resistance spot welding of aluminum alloy and advanced high strength steel that creates a stronger bond by using a chromium-rich interlayer. The interlayer improves joint strength, ductility, and toughness compared to traditional methods.
Resistance welding is used to combine two metals at one point. This technique is used extensively in automotive manufacturing, combining an aluminum (Al) to an advanced high strength steel (AHSS) structure. Welding Al and AHSS together directly, however, does not create a high-quality bond, due to…
  • College: College of Engineering (COE)
  • Inventors: Ramirez, Antonio; Lara, Bryan; Reghine Giorjao, Rafael Arthur
  • Licensing Officer: Zinn, Ryan

Method for aligning multiple lasers using axial sensor data.
TS-054019 — This technology improves the additive manufacturing process by aligning the multiple lasers to one reference point. The reference laser provides real time feedback to the other lasers thereby minimizing seam defects resulting in a higher quality print. .tb_button {padding:1px;cursor:pointer;border-right: 1px solid #8b8b8b;border-left: 1px solid #FFF;border-bottom: 1px solid #fff;}.tb_button.hover {borer:2px outset #def; background-color: #f8f8f8 !important;}.ws_toolbar {z-index:100000} .ws_toolbar .ws_tb_btn {cursor:pointer;border:1px solid #555;padding:3px} .tb_highlight{background-color:yellow} .tb_hide {visibility:hidden} .ws_toolbar img {padding:2px;margin:0px}
The additive manufacturing (AM) market has been steadily growing and has recently surpassed the $10 billion in market revenue. To keep up with this demand for less expensive, larger parts, users are turning to multi-laser machines to scale the technology. Each machine has a coordinate system w…
  • College: College of Engineering (COE)
  • Inventors: Rindler, Jacob
  • Licensing Officer: Zinn, Ryan

Ultrasonically assisted wire additive manufacturing process and apparatus
TS-054013 — The ultrasonically assisted wire additive manufacturing process and apparatus is a new innovation that uses power ultrasound (UA) for benefits in processing molten metals. The UA energy is directly applied in the local deposition pool, which makes this new hybrid process applicable for building parts with any size and geometry.
Additive manufacturing (AM) is the process of 3D printing for industrial use. Instead of countertop devices printing small toys from plastic, industrial AM is used on a much larger scale to create engine blocks, plane components, and many other products made of metal alloys. AM is traditionally do…
  • College: College of Engineering (COE)
  • Inventors: Liu, Xun; Pfeifer, Eddie "Ed"; Wang, Tianzhao
  • Licensing Officer: Zinn, Ryan

Mobile Harmful Contaminant Detection System: Home Health Kit for the detection of Allergens, Chemicals and Viruses
TS-052249 — A tool for simply and affordably assessing levels of certain household allergens (including asthma triggers), chemical contaminants (formaldehyde) and viruses (including SARS-CoV-2).
The Need Household allergens (including Asthma triggers) Asthma is one of the most common chronic conditions among children in the United States and a major cause of childhood disability. Despite advances in medical treatment, many children have poor asthma control that results in disruptions in s…
  • College: College of Engineering (COE)
  • Inventors: Dannemiller, Karen; Parquette, Jonathan; Qin, Rongjun
  • Licensing Officer: Davis, Stewart

Dynamic Nanobiosensor Platform for Viral and Tumor Nucleic Acid Detection
TS-052072 — A rapid, nucleic acid-based, point-of-care diagnostic.
The current gold-standard molecular diagnostic assay, quantitative reverse transcriptase (RT)-PCR, although accurate, is labor intensive (5-step workflow) and time consuming. Due to centralized laboratory testing, the time to results for RT-PCR can vary from 1 day up to 2 weeks, depending on the s…
  • College: College of Engineering (COE)
  • Inventors: Halley, Patrick; Castro, Carlos; Lucas, Christopher; Marras, Alexander; Shahhosseini, Melika
  • Licensing Officer: He, Panqing

Novel Electrode for Co-factor Regeneration
TS-051995 — Method of regenerating NADPH for the production of biobutanol.
The Need NAD(P)H is used as a reducing co-factor for the synthesis of biochemicals (e.g., conversion of aldehydes to alcohols) using biocatalysts or even microbes. Butanol is an important feedstock used in the chemical industry and shows great potential as a biofuel. Butanol is produced from fossil…
  • College: College of Engineering (COE)
  • Inventors: Kadowaki, Jonathan; Gopalan, Venkat; Jones, Travis; Sengupta, Anindita; Subramaniam, Vishwanath
  • Licensing Officer: Sita, Cordellia

Method for seamless joining and repair of metal parts using ultrasonic additive manufacturing
TS-050479 — This invention provides a method for repairing metal parts by removing and replacing worn, damaged, or defective metal material. It also serves as a method for seamlessly joining metal sheets and other parts while retaining the original temper of the joined parts. This technology, based on ultrasonic additive manufacturing (UAM), achieves strong joints and repairs by enabling the filling of a channel that has been cut, formed, or otherwise created in a metal structure or between two metal structures.
The aircraft industry requires robust methods for joining metal sheets, structures, and assemblies together in wings, fuselages, and engines. Fusion-based welding methods cannot always be used because they create heat-affected zones, which reduce the mechanical performance of material around the w…
  • College: College of Engineering (COE)
  • Inventors: Dapino, Marcelo; Gingerich, Mark; Headings, Leon
  • Licensing Officer: Zinn, Ryan

Redox Relay Flow Batteries: hybrid systems for scalable, high-capacity batteries.
TS-050105 — This application relates generally to a novel redox relay flow batteries comprising redox-active solids configured to behave as storage materials and redox-active organic molecules configured to behave as energy shuttles.
The Need The growing global demand for electrical energy has increased research efforts towards the integration of renewable energy sources into the electrical grid. Generation of energy from petroleum-based sources dominates the current market, but dependence on renewable energy is expected to gro…
  • College: College of Arts & Sciences
  • Inventors: Sevov, Christo; Wong, Curt
  • Licensing Officer: Sita, Cordellia

Integrally Joined Stainless Steel-NiTi Medical Devices
TS-050057 — A method for manufacturing surgical tools and implants with strong, gapless joints between NiTi (Nitinol) and stainless steel to capitalize on the best properties of both materials.
NiTi (Nitinol) is widely accepted and used for medical devices such as surgical tools and implants due to its biocompatibility and unique thermal-mechanical properties which provide super-elastic or shape memory responses. However, there are currently no commercial solutions for joining of NiTi to…
  • College: College of Engineering (COE)
  • Inventors: Panton, Boyd; Dapino, Marcelo; Gingerich, Mark; Headings, Leon; Morris, Jennifer
  • Licensing Officer: Zinn, Ryan

High-strength/high-ductility magnesium sheet alloy for room-temperature forming
TS-048065 — A new wrought magnesium alloy with optimal mechanical and formability performance suitable for industrial applications
Magnesium (Mg), the lightest structural metal, and its alloys, with their high specific strength and low density, are promising lightweight materials for industrial applications in automotive, aerospace, and electronic sectors. A 2019 report by Business Communications Company (BCC) Research highli…
  • College: College of Engineering (COE)
  • Inventors: Luo, Aihua "Alan"; Shi, Renhai
  • Licensing Officer: Zinn, Ryan

Integration of smart materials into surgical tools and medical devices using vaporizing foil actuator technology.
TS-045092 — Shape memory alloys are metals that "remember" their original shape when deformed and can return to their initial shape when heated. These shape memory alloys cannot currently be welded to other alloys, which significantly limits their use. Current state-of-the-art methods of joining sha…
  • College: College of Engineering (COE)
  • Inventors: Panton, Boyd; Daehn, Glenn; Vivek, Anupam
  • Licensing Officer: Zinn, Ryan

Method to improve natural rubber (hevea/guayule)-toughened poly-(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) for food packaging applications
TS-044688 — Nearly all plastics that are used to produce packaging materials are petroleum-based and non-biodegradable. This makes their use undesirable to consumers in an increasingly sustainability-focused market. Therefore, the development of biologically-derived, biodegradable plastic for packaging materi…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Vodovotz, Yael; Cornish, Katrina; Koelling, Kurt; Venoor, Varun "varun"; Zhao, Xiaoying "Xiaoying"
  • Licensing Officer: Dahlman, Jason "Jay"

High-strength and Corrosion Resistant Alloy for Patient-Specific Bioresorbable Bone Fixation Hardware
TS-042526 — Novel ternary and quaternary Mg-Zn-Ca-based alloys and a heat treatment process for producing bioresorbable bone fixation implants with improved mechanical and corrosion properties
Mg-Zn-Ca-based alloys are the most promising alloy system for bone implant applications mainly due to their superior biocompatibility. For fixation applications, the ideal is a material strong enough to hold while healing (2-4 months) yet being fully resorbed after the bones have healed (6-24 mont…
  • College: College of Medicine (COM)
  • Inventors: Dean, David; Elahinia, Mohammad; Ibrahim, Hamdy
  • Licensing Officer: Norris, Francis "Frank"

Ultrasonic Resistance Spot Welding Process and Apparatus
TS-041781 — An improvement to ultrasonic and resistance spot welding
Ultrasonic welding is widely used in the electronics industry to weld together wiring in delicate circuits and on microcircuits. It is also used in the automotive industry, medical industry, and packaging industry, often to weld dissimilar materials or plastics. The major advantages in ultrasonic …
  • College: College of Engineering (COE)
  • Inventors: Liu, Xun; Benatar, Avraham; Kimchi, Menachem
  • Licensing Officer: Zinn, Ryan

Self-assembled 3D RNA Cage Nanoparticles with Precise Shape and Size for Applications in Medical Sciences, Materials Sciences, Engineering and Nanotechnology
TS-039545 — Self-assembling, highly stable RNA cages amenable to custom functionalization and cargo delivery
One of the primary challenges in therapeutic development is cheap, efficient, and safe drug delivery to specific target tissues. To better target specific tissues, RNA nanotechnology has been progressively applied to generate predefined architectures via self-assembly of modular building blocks. N…
  • College: College of Pharmacy
  • Inventors: Guo, Peixuan; Jasinski, Daniel; Khisamutdinov, Emil; Li, Hui; Xu, Congcong
  • Licensing Officer: He, Panqing

Novel small peptide polarizing agents for dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) spectroscopy
TS-038322 — Versatile small biradical peptide molecules that can serve as biradical polarizing agents for dynamic nuclear polarization (DNP) solid-state nuclear magnetic resonance spectroscopy.
DNP methodology offers dramatic sensitivity enhancements of NMR experiments (up to 1-2 orders of magnitude) by transferring the large electron spin polarization to the nuclei of interest, and is currently one of the research frontiers in the magnetic resonance field with numerous applications to b…
  • College: College of Arts & Sciences
  • Inventors: Jaroniec, Christopher; Conroy, Daniel
  • Licensing Officer: Norris, Francis "Frank"

Method for Large scale production of RNA or RNA nanoparticles via the combination of rolling circle transcription and ribozyme processing.
TS-037876 — A new method to produce RNA and RNA nanoparticles by using rolling circle transcription to produce RNA on a large scale.
Since RNA interference was first described and utilized in 1998, the field has been expanding at an immense pace. Many types of therapeutics have been developed using synthetically constructed RNA interference nanotechnology, including work in the fields of cancer, immune therapy, and other human …
  • College: College of Pharmacy
  • Inventors: Guo, Peixuan; Jasinski, Daniel
  • Licensing Officer: He, Panqing

Electrolyte to Enable Reversible Dendrite-Free Potassium Plating and Stripping for Potassium Secondary Batteries
TS-037854 — A novel electrolyte to prevent dendrite growth in potassium air batteries.
The Need Potassium-air batteries have recently emerged as alternative energy storage devices beyond lithium-ion batteries. However, potassium metal anodes suffer from poor reversibility during plating and stripping processes due to their high reactivity and unstable solid electrolyte interphase (SE…
  • College: College of Arts & Sciences
  • Inventors: Wu, Yiying; McCulloch, William; Xiao, Neng
  • Licensing Officer: Sita, Cordellia

Nanopump Separation Device and Method
TS-037584 — A device for separating macromolecules in a solution of macromolecules having different molecular sizes
Many clinical and research applications involve separation of specific biological molecules, such as nucleic acids and proteins, for further analysis and characterization. A complex biological system can only be understood after each component has been separately analyzed, and proteins must be pur…
  • College: College of Engineering (COE)
  • Inventors: Hansford, Derek; Walczak, Robbie
  • Licensing Officer: Zinn, Ryan

A Gas-Assisted Resin Injection Technique for Bonding and Surface Modification of Microfluidic Devices
TS-037577 — A new resin gas-assisted injection technique, which can achieve both bonding and surface modification of microfluidic devices
The application of microfluidic platforms is limited because the materials and production methods are too expensive, and the material properties induce problems, such as a lack of optical clarity and low impact strength. Packaging (i.e. sealing a device with a lid) is also a challenge in the fabri…
  • College: College of Engineering (COE)
  • Inventors: Lee, L James; Lai, Siyi
  • Licensing Officer: Norris, Francis "Frank"

Metabolic Engineering of Clostridium Tyrobutyricum for Butanol Production
TS-037555 — A new strain of bacteria that can produce butanol at a high titer for transportation fuel.
Butanol is generally used as an industrial solvent but can also be blended with gasoline and used as transportation fuel. Butanol is commonly produced using fossil fuels, but it can also be produced from biomass, referred to as biobutanol. Biobutanol is produced from fermentation of the same feeds…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Yu, Mingrui
  • Licensing Officer: Sita, Cordellia

Al-Cr-Ti-V Based High Entropy Alloys
TS-037543 — Innovative alloys displaying extremely high strength and improving upon other mechanical properties
High entropy alloys (HEA) are a new class of multiple-principle-element alloys stabilized by large configurational entropy. HEA offer exceptional mechanical, chemical, and magnetic properties at room and elevated temperatures. Current efforts in the HEA field have focused on developing new materia…
  • College: College of Engineering (COE)
  • Inventors: Luo, Aihua "Alan"; Huang, Xuejun; Sun, Weihua
  • Licensing Officer: Sita, Cordellia

N-Proanol and Propionic Acid Producing Propionibacteria
TS-037515 — New method of producing n-propanol and propionic acid using a metabolically engineered propionibacteria.
Propionibacteria are well-known for their various industrial applications including the manufacturing of Swiss cheese, vitamin B12, and propionic acid. However, not much is known about their genetics, and few studies have been conducted utilizing them for metabolic engineering, mostly in vitamin B…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Ammar, Ehab
  • Licensing Officer: Sita, Cordellia

Method for Repellency of Surfactant-Containing Liquids Using Nanoparticles and Binder
TS-037423 — A surface coating which repels both oil and water.
Materials with a coating that repels both water and oil would be advantageous across a wide variety of industries and products. Benefits of this kind of coating could include anti­fouling, self-cleaning, and anti­smudging capabilities. While modern clear coats and paints do offer protectio…
  • College: College of Engineering (COE)
  • Inventors: Martin, Samuel; Bhushan, Bharat
  • Licensing Officer: Norris, Francis "Frank"

Nanoparticle and Long Fiber Reinforced Thermoset Nanocomposites
TS-037388 — A method to combine the advantages of both fiber reinforced plastics and polymer nanocomposites to produce a superior composite material.
Dispersion of nanoparticles into fiber reinforced plastics (FRPs) produces superior composites. Current methods face two problems: (1) best practices to disperse nanoparticles FRPs are not defined and (2) methods to maintain resin processability in the presence of nanoparticles are not understood.…
  • College: College of Engineering (COE)
  • Inventors: Lee, L James; Cao, Xia; Zhou, Gang
  • Licensing Officer: Norris, Francis "Frank"

Synthesis and Foaming of Water Containing Activated Carbon-Nano/Microparticulate Polystyrene
TS-037386 — A novel method to increase thermal efficiency infrared absorption and bulk density of polystyrene foams.
Blowing agents create a cellular structure from a liquid plastic resin and, in certain cases, function as an insulating component of the foam. Hydrogen-containing chlorofluorocarbons and fluorocarbons are common blowing agents in the foam industry for extrusion forming of Polystyrene foam. However…
  • College: College of Engineering (COE)
  • Inventors: Lee, L James; Chiou, Nan-Rong; Yang, Jintao; Yeh, Shu Kai
  • Licensing Officer: Norris, Francis "Frank"

Fabrication of Nanopapers and Nanoparticle Reinforced Polymeric Composites Using Vacuum-Assisted Layer-by-Layer Spraying Technique
TS-037364 — A method to combine advantages of fiber-reinforced plastics and nanocomposites to produce a low-cost, superior lightweight material.
Nanomaterials, more specifically nanoparticle reinforced composites, are one of the best solutions for most lightweight applications. Due to the dispersion and high aspect ratio of nanoparticles, lightweight polymer nanocomposites exhibit dimensional stability, heat and flame resistance, barrier p…
  • College: College of Engineering (COE)
  • Inventors: Lee, L James; Guerra, Dante; Min, Yong Gang; Movva, Siva
  • Licensing Officer: Norris, Francis "Frank"

Porous Thermoelectric Materials
TS-037351 — A formulation to increase the efficiency of thermoelectric materials by reducing density.
Thermoelectric effects enable direct conversion of thermal to electrical energy, which provides an alternative power generation and temperature conditioning. Although thermoelectric systems are environmentally friendly, the efficiency of thermoelectric devices cannot compete with current gold-stan…
  • College: College of Engineering (COE)
  • Inventors: Heremans, Joseph; Jaworski, Christopher
  • Licensing Officer: Gooray, Arthur "Art"

Cobalt-Free, Galling and Wear Resistant Austenitic Stainless Steel Hard-Facing Alloy
TS-037336 — A powder-form alloy providing high galling, wear, and erosion resistance.
Hard-facing alloys are used for a variety of applications due to their material properties, which include high galling resistance, good wear resistance, high strength and erosion performance, corrosion performance, and high hardness. Most hard-facing alloys fall into one of three alloy categories:…
  • College: College of Engineering (COE)
  • Inventors: Babu, Sudarsanam; Frederick, Gregory; Gandy, David; Lherbier, Lou; Lolla, Tapasvi; Novotnak, David; Siefert, John; Smith, Ryan
  • Licensing Officer: Sita, Cordellia

Engineered Guide RNA as a Tool for CRISPR/Cpf1 Gene Editing
TS-036754 — This technology aims to optimize the CRISPR-Cpf1 complex by chemically modifying the crRNA nucleotides and engineering crRNA sequences.
CRISPR technology is a new and exciting tool for editing the genomes of live organisms. With CRISPR, researchers have replaced target genes with chosen alternative genes in species ranging from bacteria to live mice. The CRISPR system uses either the Cas9 or Cpf1 protein to bind a given DNA sequen…
  • College: College of Pharmacy
  • Inventors: Dong, Yizhou; Li, Bin
  • Licensing Officer: He, Panqing

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