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Anti-GARP Monoclonal Antibodies for Cancer Therapy
TS-057778 — A novel monoclonal antibody (PIIO-1) to be used in combination with immune-checkpoint blockers. PIIO-1 augments CD8+ T cells-induced anti-tumor immunity and overcomes ICB resistance by disrupting transforming growth factor-β (TGF-β), the center of a pathway significantly implicated in solid tumors and hematological malignancies. PIIO-1 inhibits TGFβ locally via a docking receptor, avoiding adverse and unforeseen side effects.
Although immune checkpoint blockade (ICB) has emerged as a promising cancer immunotherapy, a majority of tumors fail to respond to ICB. A potential mechanism driving this failed response is the accumulation of TGF-β1 in the tumor microenvironment (TME), which drives immune dysfunction by indu…
  • College: College of Medicine (COM)
  • Inventors: Li, Zihai
  • Licensing Officer: He, Panqing

An Orally Active, Selective Inhibitor of CD4+ T-Cell Activation That Blunts Left-Ventricular Remodeling and Improves Cardiac Function during Chronic Heart Failure
TS-057777 — A novel orally-active drug molecule that can inhibit pathological CD4+ T-cells at clinically translatable doses and, blunts progressive cardiac dysfunction and left-ventricular (LV) remodeling during Heart Failure (HF).
HF afflicts ~6.5 million adults in US with 50% mortality in first 5 years. It has an estimated market size of $4.2B USD in US alone with a forecasted CAGR of 23% from 2018-2028. Current HF treatments are mostly aimed at alleviating symptoms rather than treatment, resulting in progressive cardiac d…
  • College: College of Medicine (COM)
  • Inventors: Bansal, Shyam; Gumina, Richard
  • Licensing Officer: He, Panqing

Albumin-SN-38 Conjugate (AlbuCure) for Cancer Therapy
TS-057776 — A novel protein-drug conjugate of human serum albumin chemically conjugated to SN-38, solubilizing the potent chemotherapeutic. This therapy has the potential to treat many tumors with poor prognosis, including pancreatic, lung, breast, colorectal, ovarian, sarcoma, head and neck cancer, urothelial malignancies, and others.
Many solid tumors have poor prognosis despite recent progress in molecularly targeted therapy and immunotherapy. Irinotecan/CPT-11, a chemotherapy on the WHO Essential Medicines List, is approved for use in colorectal cancer, lung cancer, pancreatic cancer, gastric cancer, malignant glioma, and sa…
  • College: College of Medicine (COM)
  • Inventors: Williams, Terence; Lee, Robert
  • Licensing Officer: He, Panqing

Reduction in Incidence and Severity of Acute Graft-Versus-Host Disease (aGVHD) via CRISPR-Cas9 Deletion of the miR-155 Host Gene (MIR155HG) in Primary Human T Cells
TS-057739 — CRISPR/Cas 9 mediated targeting of MIR155HG in primary human T cells creates genomic deletions that disrupt transcription of mature microRNA-155 (miR-155, a miR associated with inflammation). Applying this treatment to donor T cells prior to allogenic hematopoietic stem cell transplantation (allo-HSCT) when treating hematological malignancies and other primary bone marrow disorders can prevent the development of aGVHD in patients.
The Need More than 8,000 patients receive allo-HSCT annually in the US alone as a cure for hematologic malignancies and other primary bone marrow disorders. However, the major barrier for the success of allo-HSCT is the high incidence of aGVHD and its associated morbidity and mortality. Acute GVHD…
  • College: College of Medicine (COM)
  • Inventors: Ranganathan, Parvathi; Garzon, Ramiro
  • Licensing Officer: He, Panqing

X-Ray Assistive Device for Standardizing the Knee Templating Process
TS-054471 — Knee templating is used as part of the pre-operative planning for knee replacement to determine the best fit for an implant. The current assistive devices used to determine fit are unreliable and inaccurate for proper patient fit. A new device is suggested to overcome these limitations.
Over 600,000 knee replacements are performed per year. As part of the pre-operative planning for surgery, x-ray images are taken to determine the proper fit for the implant. Even with the use of a calibration ball, this knee templating procedure remains inaccurate and unreliable for a number of re…
  • College: College of Engineering (COE)
  • Inventors: Ruegsegger, Mark; Aery, Dylan; Browske, Kimberly; Cantrell, Kaleb "Kaleb"; Reilman, Zach; Thew, Maddie
  • Licensing Officer: Zinn, Ryan

Therapeutic uses of the scavenging protein cocktail to treat plasma protein imbalances or depletion
TS-053103 — Uncontrolled hemolysis (i.e., destruction of red blood cells) is characterized by the increase of circulating toxic cell-free hemoglobin, heme and iron in the bloodstream. In vivo, the body’s natural supply of plasma scavenger proteins acts to neutralize these toxic species. However, these scavenger proteins such as haptoglobin, hemopexin and transferrin, which detoxify hemoglobin, heme and iron, respectively, are depleted in various clinical conditions such as hemorrhagic shock, burns, surgery, organ transplantation, sepsis and trauma. Dr. Andre Palmer’s lab at The Ohio State University has developed a novel therapeutic protein mixture, which can be used to treat plasma protein imbalances or depletion caused by the adverse events described above. The properties of this protein mixture are beneficial as they lend themselves to an inexpensive manufacturing process and potential improvements in clinical outcomes.
Fluid replacement as part of resuscitation efforts in clinical care is a cornerstone of treatment especially in cases with severe trauma. The regular usage of these fluids in hospitals requires the mixture to be easily transported, easily stored and applicable across a wide variety of patients. To…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Cabrales, Pedro; Palmer, Andre
  • Licensing Officer: Davis, Stewart

Novel Ergonomic Scalpel Handle
TS-051663 — Alleviate and prevent occupational stresses using this novel scalpel design.
A highly unfortunate outcome of the 2020 coronavirus pandemic is the over 400,000 American deaths that have unexpectedly overloaded medical autopsy services across the United States. With this heightened need for autopsy services previously unseen occupational hazards relating to repetitive motion…
  • College: College of Medicine (COM)
  • Inventors: Sachire, Jennifer
  • Licensing Officer: Schworer, Adam

Activation of human Argonaute3 (AGO3) using cityRNAs
TS-051298 — MicroRNAs (miRNAs) are small non-coding RNAs that control gene expression post-transcriptionally. Their sequences differ, but their lengths fall within a range of ~20-23 nucleotides because the precursor miRNAs are processed by Dicer. Dicer cleaves long double-stranded RNA (dsRNA) molecules into s…
  • College: College of Arts & Sciences
  • Inventors: Nakanishi, Kotaro; Park, Mi Seul
  • Licensing Officer: Willson, Christopher

Novel acellular vaccine for protection against Bordetella infection
TS-050524 — Despite high vaccine coverage, whooping cough caused by Bordetella pertussis remains one of the most common vaccine-preventable diseases worldwide. Introduction of whole-cell pertussis (wP) vaccines in the 1940s and acellular pertussis (aP) vaccines in 1990s reduced mortality due to pertussis. Des…
  • College: College of Medicine (COM)
  • Inventors: Deora, Rajendar; Mishra, Meenu; Sukumar, Neelima
  • Licensing Officer: Schworer, Adam

Mini-PCDH15 for treatment of deafness
TS-050433 — A gene therapy solution for Usher Syndrome Type 1F.
Mutations in PCDH15 cause Usher 1F, a recessive syndrome characterized by profound congenital deafness and absence of vestibular function, and progressive blindness beginning in the second decade. Because patients who lack hearing and balance rely on vision for communication and mobility, the late…
  • College: College of Arts & Sciences
  • Inventors: Sotomayor, Marcos
  • Licensing Officer: Willson, Christopher

SARS-CoV-2 Diagnostic Assay with Sensors of Immune Activation
TS-050296 — A sequencing-based diagnostic assay for SARS-CoV-2 with sensors of immune activation and the viral microbiota.
Diagnosis of SARS-CoV-2 infection, which is responsible for COVID-19 disease, is typically performed by molecular analysis of upper respiratory sampling (e.g. nasal swab). Transcriptional-mediated amplification (TMA) and quantitative (real-time) polymerase chain reaction (qPCR) using one or more v…
  • College: College of Medicine (COM)
  • Inventors: Jones, Daniel; Avenarius, Matthew; Tu, Huolin
  • Licensing Officer: Schworer, Adam

Smart Platform for Engineered Electroceutical Dressings (SPEEDs) Enables Better Wound Care
TS-050245 — An integrated platform with multiple sensing modalities to actively orchestrate antimicrobial activity and wound healing.
Wound healing and disinfection for chronic wounds presents significant hurdles within the medical industry. Current state of art is inadequate and adds a significant cost burden to the healthcare system with many health and life-quality challenges for patients. After the formation of an open wound…
  • College: College of Engineering (COE)
  • Inventors: Prakash, Shaurya; Heald, Rachel; Mohana Sundaram, Prashanth; Narayanan, Kavya; Stoodley, Paul; Subramaniam, Vishwanath; Vilku, Gurleen; Wilgus, Traci; Wozniak, Daniel
  • Licensing Officer: He, Panqing

Apoprotein manufacturing and methods for protein purification
TS-050238 — Methods of purifying proteins that can be used in various applications such as drug delivery, bioimaging and hemolysis treatment.
Novel protein and apoprotein purification strategies are valuable tools with a wide variety of medical and research applications. While there are existing techniques for protein and apoprotein purification, some of these have flaws such as the use of harsh denaturants, highly flammable solvents, l…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Cabrales, Pedro; Palmer, Andre
  • Licensing Officer: Davis, Stewart

Novel Natural Product Derivatives Targeting Chronic Diseases
TS-050220 — Novel natural products and derivatives thereof that exhibit potent in vitro and in vivo activity
The Need Metabolic disorders such as type 2 diabetes are a major health concern that have impacted hundreds of millions of adults worldwide. Current pharmaceutical therapies for type 2 diabetes have been associated with adverse reactions including weight gain and increased risk of infection, liver …
  • College: College of Pharmacy
  • Inventors: Carcache de Blanco, Esperanza; Anaya Eugenio, Gerardo David; Eggers, Nicole
  • Licensing Officer: He, Panqing

Integrally Joined Stainless Steel-NiTi Medical Devices
TS-050057 — A method for manufacturing surgical tools and implants with strong, gapless joints between NiTi (Nitinol) and stainless steel to capitalize on the best properties of both materials.
NiTi (Nitinol) is widely accepted and used for medical devices such as surgical tools and implants due to its biocompatibility and unique thermal-mechanical properties which provide super-elastic or shape memory responses. However, there are currently no commercial solutions for joining of NiTi to…
  • College: College of Engineering (COE)
  • Inventors: Panton, Boyd; Dapino, Marcelo; Gingerich, Mark; Headings, Leon; Morris, Jennifer
  • Licensing Officer: Zinn, Ryan

Targeting circular PCMTD1 in leukemias with p53 mutations
TS-049827 — circPCMTD1 is a novel target in p53 mutated leukemias.
Despite recent progress in understanding acute myeloid leukemia (AML) biology and the use of intensive treatments, the long-term overall survival of non-pediatric AML patients is only 30-40% in young patients (<60 years) and less than 10% in elderly AML patients (>60 years). This highlights …
  • College: College of Medicine (COM)
  • Inventors: Garzon, Ramiro; Papaioannou, Dimitrios
  • Licensing Officer: He, Panqing

Inhibition of DGAT for the treatment of cancer
TS-049730 — Dysregulated fat metabolism is an established hallmark of cancer cells. However, the disruption of lipid homeostasis in cancer cells remains an elusive target for therapy. Tumor cells acquire abundant fats for rapid cell growth, but how they avoid toxicity from such loading is unknown. An answer t…
  • College: College of Medicine (COM)
  • Inventors: Guo, Deliang
  • Licensing Officer: He, Panqing

An improved base editor (iABE-NG) for correcting genetic diseases such as Duchenne muscular dystrophy
TS-049505 — An engineered base editor (iABE-NG) that uses an SpCas9 variant, a shortened adenine deaminase domain with eliminated RNA off-target activity, and an intein split for packaging into an adeno-associated virus (AAV), resulting in gene mutation correction.
There are thousands of monogenic diseases that are lacking effective therapeutic treatments. The main bottleneck in developing effective treatment is the ability to effectively edit gene while controlling for the myriad of off-target effects that come with targeting the genome. Duchenne Muscular D…
  • College: College of Medicine (COM)
  • Inventors: Han, Renzhi; Gao, Yandi; Xu, Li
  • Licensing Officer: Davis, Stewart

A Novel Vaccine for Listeriosis Infection
TS-049471 — Listeriosis is an infectious disease caused by the bacterial pathogen Listeria monocytogenes. Although the average number of cases is moderate in the United States (1600-2500/year), listeriosis is a significant health concern due to its exceptionally high fatality rate. Indeed, listeriosis is the …
  • College: OSU Wexner Medical Center
  • Inventors: Seveau, Stephanie
  • Licensing Officer: He, Panqing

Novel epipolythiodioxopiperazine alkaloid natural product derivatives for the treatment of cancer and other diseases
TS-047118 — Analogues of verticillin with significantly improved drug-like properties, including increased solubility, absorption, and stability, while maintaining similar anticancer potency as the verticillin parent compounds.
Verticillins, which are epipolythiodioxopiperazine (ETP) alkaloids, have shown promising anticancer qualities; these fungal metabolites have exhibited high potency against a variety of tumor cell types, with IC50 values typically in the 10-500 nanomolar range. However, these compounds suffer from …
  • College: College of Pharmacy
  • Inventors: Fuchs, James; Huntsman, Andrew
  • Licensing Officer: He, Panqing

Integration of smart materials into surgical tools and medical devices using vaporizing foil actuator technology.
TS-045092 — Shape memory alloys are metals that "remember" their original shape when deformed and can return to their initial shape when heated. These shape memory alloys cannot currently be welded to other alloys, which significantly limits their use. Current state-of-the-art methods of joining sha…
  • College: College of Engineering (COE)
  • Inventors: Panton, Boyd; Daehn, Glenn; Vivek, Anupam
  • Licensing Officer: Zinn, Ryan

Improved Dressing Design for Insertion Sheaths with Side Ports
TS-044969 — Dressing designed and tailored exclusively for insertion sheaths with side ports, used frequently for pulmonary artery catheters (PACs or Swan-Ganz catheters) among other intravascular devices in the hospital.
Central-line associated blood stream infections (CLABSIs) are a life-threatening and extremely costly problem in hospitals around the world. When patients in the hospital have indwelling catheters such as pulmonary artery catheters, they are at an increased risk of developing infections. Occlusive…
  • College: OSU Wexner Medical Center
  • Inventors: Warren, Samantha; Thomas, Jordan
  • Licensing Officer: Davis, Stewart

Electrophiles for Re-activation of Aged Acetylcholine Esterase
TS-044619 — Organophosphorus (OP) poisons including sarin, VX, and novichoks are lethal agents of chemical warfare. Their toxicity is due to their direct inhibition of acetylcholinesterase (AChE), an enzyme that is vital to the nervous system via regulation of the neurotransmitter acetylcholine (ACh). AChE in…
  • College: College of Arts & Sciences
  • Inventors: Hadad, Christopher; Callam, Christopher; Corrigan, Thomas; Dicken, Rachel; Dogan Ekici, Ozlem; Fitzpatrick, Keegan; Franjesevic, Andrew; McElroy, Craig; McKenney, Ryan; Muthukrishnan, Siva; Sanan, Toby; Vyas, Shubham; Yoder, Ryan; Young, Amneh "Amneh"
  • Licensing Officer: Willson, Christopher

Biomimetic vitreous substitute with ocular drug delivery
TS-044490 — Methods and compositions for an antioxidant releasing hydrogel vitreous substitute
The vitreous humor is a fragile, transparent tissue between the lens and the retina of the eye that maintains the shape of the eye, acts as a shock absorber, and enables nutrient diffusion to ocular tissues. The vitreous also plays a key role in oxygen homeostasis. Over time, the vitreous degrades…
  • College: College of Engineering (COE)
  • Inventors: Swindle-Reilly, Katelyn; Reilly, Matthew; Tram, Nguyen "Archie"
  • Licensing Officer: Norris, Francis "Frank"

Live vaccine candidate for Chagas disease
TS-044084 — Trypanosoma cruzi is a protozoan parasite that causes Chagas disease, a PRV-eligible disease that is the leading cause of heart failure in Latin America. Due to migration of infected hosts from endemic regions, Chagas disease is also a growing public health concern in the USA and other migrant des…
  • College: College of Medicine (COM)
  • Inventors: McGwire, Bradford
  • Licensing Officer: He, Panqing

DNA-cage erasable labels for fluorescence-based imaging
TS-043819 — Compositions and methods for analyzing multiple biomarkers without damaging tissue.
Histopathology is a cornerstone of tissue analysis used to diagnose many clinical conditions. Many of these diagnoses are based on identifying the presence of specific biomarkers, which can be indicated by colored labels. Currently, only 1-2 markers can be analyzed per slide, reducing accuracy and…
  • College: College of Engineering (COE)
  • Inventors: Winter, Jessica; Jergens, Elizabeth; Lee, Kil Ho "Kilho"
  • Licensing Officer: Willson, Christopher

Louie: An Augmented Reality Sensory Trigger Wayfinding System for People with Autism
TS-043077 — An Augmented Reality Sensory Trigger Wayfinding System for People with Autism
Millions of people on the Autism spectrum face challenges getting from place to place due to sensory sensitivities to sounds, sights, smells, tastes, physical feelings, and crowds. Due to these triggers, people with Autism have a strong need to know where they are going and what will be there so t…
  • College: College of Engineering (COE)
  • Inventors: Ezell, Jonathan; Kaufman, Robert; Kaufman, Michael
  • Licensing Officer: Davis, Stewart

High-strength and Corrosion Resistant Alloy for Patient-Specific Bioresorbable Bone Fixation Hardware
TS-042526 — Novel ternary and quaternary Mg-Zn-Ca-based alloys and a heat treatment process for producing bioresorbable bone fixation implants with improved mechanical and corrosion properties
Mg-Zn-Ca-based alloys are the most promising alloy system for bone implant applications mainly due to their superior biocompatibility. For fixation applications, the ideal is a material strong enough to hold while healing (2-4 months) yet being fully resorbed after the bones have healed (6-24 mont…
  • College: College of Medicine (COM)
  • Inventors: Dean, David; Elahinia, Mohammad; Ibrahim, Hamdy
  • Licensing Officer: Norris, Francis "Frank"

Machine-Learning Algorithm for Improved Speech Intelligibility in Noise
TS-042266 — A monaural machine-learning algorithm for classifying time-frequency units in an unknown signal, which results in marked speech-intelligibly improvements in noisy signals.
A primary complaint of hearing-impaired (HI) listeners is poor speech recognition in background noise. This issue can be quite debilitating and persists despite considerable efforts to improve hearing technology. Despite considerable effort, monaural (single-microphone) algorithms capable of incre…
  • College: College of Arts & Sciences
  • Inventors: Healy, Eric; Vasko, Jordan
  • Licensing Officer: Willson, Christopher

Antennae and sensor impregnated mat to monitor biological variables and indicators of health
TS-041742 — A functional fabric mat with the capability to monitor and track anthropometric and biofeedback data accompanied by an application to integrate information and securely share with healthcare providers.
Currently, anthropometric and biological measurements in the healthcare setting are made with individual devices that require both specialized equipment and time on the part of the patient and healthcare provider. Additionally, patient data is often static in nature as the opportunity for measurem…
  • College: College of Nursing
  • Inventors: Militello, Lisa; Kiourti, Asimina
  • Licensing Officer: Davis, Stewart

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