# of Displayed Technologies: 19 / 19

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X-Ray Assistive Device for Standardizing the Knee Templating Process
TS-054471 — Knee templating is used as part of the pre-operative planning for knee replacement to determine the best fit for an implant. The current assistive devices used to determine fit are unreliable and inaccurate for proper patient fit. A new device is suggested to overcome these limitations.
Over 600,000 knee replacements are performed per year. As part of the pre-operative planning for surgery, x-ray images are taken to determine the proper fit for the implant. Even with the use of a calibration ball, this knee templating procedure remains inaccurate and unreliable for a number of re…
  • College: College of Engineering (COE)
  • Inventors: Ruegsegger, Mark; Aery, Dylan; Browske, Kimberly; Cantrell, Kaleb "Kaleb"; Reilman, Zach; Thew, Maddie
  • Licensing Officer: Randhawa, Davinder

Novel Ergonomic Scalpel Handle
TS-051663 — Alleviate and prevent occupational stresses using this novel scalpel design.
A highly unfortunate outcome of the 2020 coronavirus pandemic is the over 400,000 American deaths that have unexpectedly overloaded medical autopsy services across the United States. With this heightened need for autopsy services previously unseen occupational hazards relating to repetitive motion…
  • College: College of Medicine (COM)
  • Inventors: Sachire, Jennifer
  • Licensing Officer: Schworer, Adam

Smart Platform for Engineered Electroceutical Dressings (SPEEDs) Enables Better Wound Care
TS-050245 — An integrated platform with multiple sensing modalities to actively orchestrate antimicrobial activity and wound healing.
Wound healing and disinfection for chronic wounds presents significant hurdles within the medical industry. Current state of art is inadequate and adds a significant cost burden to the healthcare system with many health and life-quality challenges for patients. After the formation of an open wound…
  • College: College of Engineering (COE)
  • Inventors: Prakash, Shaurya; Heald, Rachel; Mohana Sundaram, Prashanth; Narayanan, Kavya; Stoodley, Paul; Subramaniam, Vishwanath; Vilku, Gurleen; Wilgus, Traci; Wozniak, Daniel
  • Licensing Officer: He, Panqing

Integrally Joined Stainless Steel-NiTi Medical Devices
TS-050057 — A method for manufacturing surgical tools and implants with strong, gapless joints between NiTi (Nitinol) and stainless steel to capitalize on the best properties of both materials.
NiTi (Nitinol) is widely accepted and used for medical devices such as surgical tools and implants due to its biocompatibility and unique thermal-mechanical properties which provide super-elastic or shape memory responses. However, there are currently no commercial solutions for joining of NiTi to…
  • College: College of Engineering (COE)
  • Inventors: Panton, Boyd; Dapino, Marcelo; Gingerich, Mark; Headings, Leon; Morris, Jennifer
  • Licensing Officer: Zinn, Ryan

Integration of smart materials into surgical tools and medical devices using vaporizing foil actuator technology.
TS-045092 — Shape memory alloys are metals that "remember" their original shape when deformed and can return to their initial shape when heated. These shape memory alloys cannot currently be welded to other alloys, which significantly limits their use. Current state-of-the-art methods of joining sha…
  • College: College of Engineering (COE)
  • Inventors: Panton, Boyd; Daehn, Glenn; Vivek, Anupam
  • Licensing Officer: Zinn, Ryan

Improved Dressing Design for Insertion Sheaths with Side Ports
TS-044969 — Dressing designed and tailored exclusively for insertion sheaths with side ports, used frequently for pulmonary artery catheters (PACs or Swan-Ganz catheters) among other intravascular devices in the hospital.
Central-line associated blood stream infections (CLABSIs) are a life-threatening and extremely costly problem in hospitals around the world. When patients in the hospital have indwelling catheters such as pulmonary artery catheters, they are at an increased risk of developing infections. Occlusive…
  • College: OSU Wexner Medical Center
  • Inventors: Warren, Samantha; Thomas, Jordan
  • Licensing Officer: Csatary, Erika

Biomimetic vitreous substitute with ocular drug delivery
TS-044490 — Methods and compositions for an antioxidant releasing hydrogel vitreous substitute
The vitreous humor is a fragile, transparent tissue between the lens and the retina of the eye that maintains the shape of the eye, acts as a shock absorber, and enables nutrient diffusion to ocular tissues. The vitreous also plays a key role in oxygen homeostasis. Over time, the vitreous degrades…
  • College: College of Engineering (COE)
  • Inventors: Swindle-Reilly, Katelyn; Reilly, Matthew; Tram, Nguyen "Archie"
  • Licensing Officer: Schworer, Adam

DNA-cage erasable labels for fluorescence-based imaging
TS-043819 — Compositions and methods for analyzing multiple biomarkers without damaging tissue.
Histopathology is a cornerstone of tissue analysis used to diagnose many clinical conditions. Many of these diagnoses are based on identifying the presence of specific biomarkers, which can be indicated by colored labels. Currently, only 1-2 markers can be analyzed per slide, reducing accuracy and…
  • College: College of Engineering (COE)
  • Inventors: Winter, Jessica; Jergens, Elizabeth; Lee, Kil Ho "Kilho"
  • Licensing Officer: Willson, Christopher

High-strength and Corrosion Resistant Alloy for Patient-Specific Bioresorbable Bone Fixation Hardware
TS-042526 — Novel ternary and quaternary Mg-Zn-Ca-based alloys and a heat treatment process for producing bioresorbable bone fixation implants with improved mechanical and corrosion properties
Mg-Zn-Ca-based alloys are the most promising alloy system for bone implant applications mainly due to their superior biocompatibility. For fixation applications, the ideal is a material strong enough to hold while healing (2-4 months) yet being fully resorbed after the bones have healed (6-24 mont…
  • College: College of Medicine (COM)
  • Inventors: Dean, David; Elahinia, Mohammad; Ibrahim, Hamdy
  • Licensing Officer: Schworer, Adam

Machine-Learning Algorithm for Improved Speech Intelligibility in Noise
TS-042266 — A monaural machine-learning algorithm for classifying time-frequency units in an unknown signal, which results in marked speech-intelligibly improvements in noisy signals.
A primary complaint of hearing-impaired (HI) listeners is poor speech recognition in background noise. This issue can be quite debilitating and persists despite considerable efforts to improve hearing technology. Despite considerable effort, monaural (single-microphone) algorithms capable of incre…
  • College: College of Arts & Sciences
  • Inventors: Healy, Eric; Vasko, Jordan
  • Licensing Officer: Willson, Christopher

Antennae and sensor impregnated mat to monitor biological variables and indicators of health
TS-041742 — A functional fabric mat with the capability to monitor and track anthropometric and biofeedback data accompanied by an application to integrate information and securely share with healthcare providers.
Currently, anthropometric and biological measurements in the healthcare setting are made with individual devices that require both specialized equipment and time on the part of the patient and healthcare provider. Additionally, patient data is often static in nature as the opportunity for measurem…
  • College: College of Nursing
  • Inventors: Militello, Lisa; Kiourti, Asimina
  • Licensing Officer: Ashouripashaki, Mandana

Papaverine Derivatives that are Effective Hypoxic Tumor Radiosensitizers
TS-041504 — Dr. Nicholas Denko and colleagues at The Ohio State University have developed papaverine derivatives that can be used as metabolic radiosensitizers in hypoxic tumors. The compounds make cancer cells more sensitive to radiation therapy without the concomitant toxicity issues that can occur as a side-effect of papaverine.
Radiation therapy is a common treatment for cancerous tumors. However, environmental conditions in the tumor can influence sensitivity to radiation therapy, and some cells are resistant to treatment. For example, hypoxic cells (those with low levels of oxygen) in tumors such as lung, glioblastoma,…
  • College: College of Medicine (COM)
  • Inventors: Denko, Nicholas; Benej, Martin; Mitton-Fry, Mark; Papandreou, Ioanna; Vibhute, Sandip
  • Licensing Officer: Schworer, Adam

Perivascular Drug Delivery Nanoplatform for Preventing Restenosis After Open Surgery
TS-039004 — Pericelle: a nanoparticle based perivascular drug delivery system to prevent stenosis and failure in vascular reconstruction surgeries
Imaging and re-intervention procedures, necessary to maintain open blood vessels following vascular reconstruction surgery, are expensive. For example, the cost of maintenance for an atriovenous (AV) fistula used in hemodialysis access has been estimated at near a staggering $15,000/year. In bypas…
  • College: College of Medicine (COM)
  • Inventors: Kent, K. Craig; Chen, Guojun; Gong, Shaoqin; Guo, Lianwang; Shi, Xudong
  • Licensing Officer: Norris, Francis "Frank"

Sustained Release Microparticles for the Treatment of Ocular Diseases
TS-038312 — A novel, intravitreal microparticle injection capable of controlled-release of protein therapies (including anti-VEGF) for tunable periods of 6-12 months after injection for the treatment of age-related macular degeneration.
Age-related macular degeneration (AMD) is the leading cause of blindness in individuals 65 and older and is the third leading cause of blindness worldwide. Wet AMD is characterized by abnormal growth of leaky blood vessels leading to damage to the macula of the retina resulting in vision loss and …
  • College: College of Engineering (COE)
  • Inventors: Jiang, Pengfei; Ohr, Matthew; Swindle-Reilly, Katelyn
  • Licensing Officer: Schworer, Adam

Machine-Learning Algorithm for Improved Speech Intelligibility in Noise
TS-038074 — A monaural machine-learning algorithm for classifying time-frequency units in an unknown signal, which results in marked speech-intelligibly improvements in noisy signals.
Wireless carriers receive daily complaints about poor speech recognition in background noise during calls and are constantly looking for methods to improve especially in light of recent forays into VOIP. The ability to discriminate between speech and noise in an audio signal then is an extremely i…
  • College: College of Arts & Sciences
  • Inventors: Healy, Eric; Vasko, Jordan
  • Licensing Officer: Willson, Christopher

Prosthetic Heart Valve With Tri-Leaflet Design For Use In Percutaneous Valve Replacement Procedures
TS-038028 — Transcatheter heart valve (THV) with novel leaflet materials and design profile that results in reduced thrombogenicity, improved durability, and lower manufacturing cost
Heart valve (HV) therapy is the second most common cardiac intervention in the U.S. with transcatheter delivery the dominant surgical approach. Most procedures employ mechanical (MHV) or bioprosthetic (BHV) devices. However, MHVs involve a significant risk of thromboembolism and require lifelong a…
  • College: College of Engineering (COE)
  • Inventors: Dasi, Lakshmi; Yousefi Koupaei, Atieh
  • Licensing Officer: Norris, Francis "Frank"

Unmanned Aerial System Stinger-Suspended Crop Health Sensing
TS-036526 — A remote sensing imaging system that combines a suspended camera with sampling probes, combined with unique image processing features.
Unmanned Aerial Systems (UAS) allow agricultural producers to generate high-resolution crop health data over large areas. UAS generate this data by imaging the upper canopy while flying above row crops. However, most crop health problems originate below the upper portion of the canopy. Most causes…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Shearer, Scott; Klopfenstein, Andrew "Andrew"; See, David; Weigman, Christopher
  • Licensing Officer: Dahlman, Jason "Jay"

Non-Contact Method for Accelerating Wound Healing
TS-015075 — Novel non-contact method for healing surface or deep wounds by inducing electric fields by applying time-varying magnetic fields.
The directional movement of biological cells in the presence of an applied electric field is known as galvanotaxis or electrotaxis. The majority of experiments related to galvanotaxis over the past two centuries have involved steady electric fields applied via electrodes placed in contact with a m…
  • College: College of Engineering (COE)
  • Inventors: Subramaniam, Vishwanath; Das Ghatak, Piya; Roy, Sashwati; Sen, Chandan; Sequin, Emily; West, Joseph
  • Licensing Officer: He, Panqing

Multi-carrier processing in auditory prosthetic devices
TS-014871 — Encoding strategy for improvement of speech understanding in a noisy environment for audiotory prosthetic devices.
There are about 275 million adults globally with moderate to severe hearing loss and 360 million adults with mild hearing loss. The current solutions to allow these people to hear better include hearing aids, hearing loss counseling, cochlear implants, alerting devices, and other communication aid…
  • College: College of Arts & Sciences
  • Inventors: Apoux, Frederic; Healy, Eric
  • Licensing Officer: Willson, Christopher

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