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Neonatal Blood Vessel Locator for Vascular Access Procedures
TS-067796 — A handheld device for identifying preterm blood vessels in neonatal ICU.
Over 300,000 preterm births in the United States occur annually, representing 10.5% of all live births. Most preterm births occur spontaneously, but some result from medical conditions like infections or pregnancy complications requiring early labor induction or cesarean delivery. Common causes of p…
  • College: College of Engineering (COE)
  • Inventors: Metzler, Sandra; Bresolin, Alejandro; Crawford, Mackenzie; Fernandes, Siddharth; Hardin, Rene; Patel, Aarti; Richards, Hannah; Trainor, Dylan
  • Licensing Officer: Zinn, Ryan

Dust Analysis: A Novel Approach to Monitoring Viral Spread
TS-066962 — The Need Viral disease surveillance (e.g. influenza, SARS-CoV-2) in high-risk settings faces several challenges, such as asymptomatic carriers, incomplete reporting, resource limitations, and delayed diagnosis of traditional swab test methods. These challenges could allow a virus to silently spread…
  • College: College of Engineering (COE)
  • Inventors: Dannemiller, Karen; Faith, Seth; Hull, Natalie; Nastasi, Nick; Renninger, Nicole
  • Licensing Officer: Ashouripashaki, Mandana

Humanized SSTR2 mAb and ADC to target SSTR2+ tumors
TS-066912 — Targeted humanized mAbs and ADCs for cancer treatment
The Liu Lab Dr. Xiaoguang “Margaret” Liu applies her industry experience (Lonza, Merck, and Life Technologies) in cell line and process development towards her lab’s focus on targeted anti-cancer therapies including monoclonal antibodies, antibody-drug conjugates, and gene therapi…
  • College: College of Engineering (COE)
  • Inventors: Liu, Xiaoguang "Margaret"; Zhou, Lufang
  • Licensing Officer: Schworer, Adam

Small Molecule USP30 Inhibitors for the Treatment and Prevention of Cardiomyopathy
TS-066773 — The Need Cardiomyopathy, a disease of the heart muscle, poses significant public health challenges due to its diverse causes, symptoms, and potential complications, including heart failure and arrhythmias. With cardiomyopathy often induced by drugs, such as anthracyclines used in chemotherapy, ther…
  • College: College of Medicine (COM)
  • Inventors: Sun, Nuo; Krigman, Judith; Yang, Mingchong; Zhang, Ruohan
  • Licensing Officer: Willson, Christopher

Biofilm Detachment Monitoring for Enhanced Oral Health Solutions
TS-066772 — The Need Biofilms, particularly dental plaque-biofilms, are communities of microorganisms encased in a slimy extracellular polymeric substance (EPS) that adhere to surfaces or neighboring microorganisms. These biofilms are responsible for various infectious diseases, including oral diseases such as…
  • College: College of Medicine (COM)
  • Inventors: Stoodley, Paul; Gloag, Erin
  • Licensing Officer: Willson, Christopher

Innovative Biomarker Technology for Detecting and Treating Endothelial Injury in Neurological Disorders
TS-066771 — Endothelial injury is a significant pathological mechanism underlying various neurological disorders, including neurodegenerative, neuroinflammatory, and cerebrovascular diseases. Current clinical and research settings lack reliable biomarkers to detect or measure endothelial injury in the human C…
  • College: College of Medicine (COM)
  • Inventors: Al Tarawneh, Rawan
  • Licensing Officer: Willson, Christopher

Innovative Small Molecule Inhibitors for Effective Treatment and Prevention of Coronavirus Infections
TS-066750 — The ongoing COVID-19 pandemic, caused by the SARS-CoV-2 virus, has significantly impacted global health and economies. Despite vaccine efforts, issues such as vaccine hesitancy, delays in distribution, and emerging variants have highlighted the need for effective therapeutic interventions. These i…
  • College: College of Veterinary Medicine
  • Inventors: Sharma, Amit; Li, Pui-Kai "Tom"; Xing, Enming
  • Licensing Officer: Willson, Christopher

T-cells with Enhanced Ability to Respond to Exogenous Ligands
TS-066052 — Novel T-cells expressing the IL-2a receptor to enhance cancer cell targeting.
The Need As interest in cell-based therapies, particularly for cancer treatment, continues to rise, there’s a critical need for therapeutic cells capable of robust proliferation in vivo. Existing methods relying on exogenous cytokines like IL-2 face challenges due to dose-limiting toxicity an…
  • College: OSU Wexner Medical Center
  • Inventors: Rubinstein, Mark
  • Licensing Officer: Willson, Christopher

Novel Antibodies Targeting IL-2
TS-066051 — Novel antibodies targeting IL-2 with the ability to inhibit IL-2 signaling through IL-2 Rαβg to a greater extent than through IL-2 Rβg.
IL-2 and its receptor IL-2R are known to play multiple roles in shaping the immune response, including both immune activation and tolerance. Expression of intermediate-affinity IL-2 receptors by different immune cell subsets determines cellular sensitivity to IL-2. However, the dynamic interplay bet…
  • College: OSU Wexner Medical Center
  • Inventors:
  • Licensing Officer: Willson, Christopher

Gene Therapy Approach for Treating Neuropathy
TS-065913 — Gene therapy strategies for treating peripheral neuropathy.
Peripheral neuropathy (PN) results in loss of innervation by the peripheral nerves in tissues such as skin, muscle, heart, and adipose tissue. It is a painful, debilitating disease, that is estimated to affect between 20 and 30 million Americans. The number of Americans affected by PN is likely muc…
  • College: College of Medicine (COM)
  • Inventors: Townsend, Kristy; Blaszkiewicz, Magdalena; Cao, Lei
  • Licensing Officer: Willson, Christopher

IDEAS: Revolutionizing Early Childhood Education with Automated Interaction Analysis
TS-065825 — The Need: In early childhood education settings, understanding children's interactions, both social and linguistic, is paramount for effective teaching and development monitoring. However, manual observation and analysis of these interactions can be time-consuming and subjective, hindering educa…
  • College: College of Education & Human Ecology
  • Inventors: Gonzalez Villasanti, Hugo "Hugo"; Justice, Laura
  • Licensing Officer: Dahlman, Jason "Jay"

Targeting Telomerase to Treat Ocular Neovascular Disorders
TS-065809 — Therapeutic strategies for treating ocular neovascular disorders by targeting telomerase.
Choroidal neovascularization (CNV) is the principal driver of blindness in neovascular age-related macular degeneration (nvAMD). Abnormal blood vessel growth beneath the macular leads to retinal damage and severe vision loss. Discovering the involvement of VEGF in the underlying mechanisms driving …
  • College: College of Medicine (COM)
  • Inventors: Kerur, Nagaraj
  • Licensing Officer: Willson, Christopher

Treating Diabetes, Obesity, and Cardiovascular Disease by Reprogramming Skin
TS-065789 — Using tissue nano-transfection to reprogram skin cells to treat diabetes, obesity and/or cardiovascular health
The incidence of obesity and diabetes is skyrocketing, leading to chronic inflammatory conditions such as cardiovascular disease, autoimmune diseases, liver diseases, and cancer. Cardiovascular disease (CVD) is the leading cause of death across the US and worldwide and affects almost half of all ad…
  • College: College of Medicine (COM)
  • Inventors: Gallego Perez, Daniel; Higuita Castro, Natalia; Sen, Chandan
  • Licensing Officer: Willson, Christopher

Revolutionizing Cancer Immunotherapy with Novel Chimeric B-cell Epitope Peptide Vaccines
TS-065697 — Chimeric B-cell epitope peptide vaccines targeting human PD-L1 and/or CTLA-4 to induce immune response against the PD-1/PD-L1 signaling pathway.
The emergence of immune checkpoint inhibitors revolutionized cancer immunotherapy. Monoclonal antibodies targeting PD-1, PD-L1 and CTLA-4 have shown impressive clinical outcomes. The Need Despite their effectiveness, current monoclonal antibody treatments have limitations such as low response ra…
  • College: College of Medicine (COM)
  • Inventors: Kaumaya, Pravin
  • Licensing Officer: Willson, Christopher

Novel Therapeutic Approach to Treating Painful Musculoskeletal Disorders
TS-065684 — Non-viral gene therapy for minimally invasively treating painful musculoskeletal disorders
Painful musculoskeletal disorders like intervertebral disc (IVD) degeneration associated with chronic low back pain (DBP) present a significant socio-economic burden worldwide. The Need Current treatments for painful musculoskeletal disorders offer only temporary relief or invasive surgical proce…
  • College: College of Engineering (COE)
  • Inventors: Walter, Devina; Gallego Perez, Daniel; Higuita Castro, Natalia; Khan, Safdar; Tang, Shirley "Shirley Nina"; Walter, Benjamin
  • Licensing Officer: Willson, Christopher

Precision RNA-PROTACs: Revolutionizing Therapeutic Targeting of Dysregulated Ribonucleoprotein Complexes
TS-065457 — The Need: In the realm of therapeutic development, there's a pressing need for precise targeting of dysregulated ribonucleoprotein (RNP) complexes to combat various diseases, particularly neurodegenerative disorders like ALS, Alzheimer’s, and Huntington’s diseases. Traditional metho…
  • College: College of Arts & Sciences
  • Inventors: Bong, Dennis; Liang, Yufeng; Miao, Shiqin "Shiqin"; Strong, Rebekah
  • Licensing Officer: Panic, Ana

MicroRNA profile predicts colon cancer prognosis
TS-065453 — The Need: Colon cancer remains one of the most prevalent and lethal forms of cancer worldwide. Timely and accurate diagnosis is critical for effective treatment and improved patient outcomes. Current diagnostic methods often lack the precision and sensitivity needed for early detection and prognosi…
  • College: College of Medicine (COM)
  • Inventors: Croce, Carlo
  • Licensing Officer: Schultz, Teri

Novel Extracellular Vesicles Loaded with Anti-Inflammatory Agents
TS-065154 — , 2018-345 Revolutionary treatment for ARDS using novel extracellular vesicles loaded with Anti-Inflammatory Agents.
The Need Acute Respiratory Distress Syndrome (ARDS) remains a significant healthcare challenge with high mortality rates and long-term morbidity. Despite advancements in supportive care, there’s an urgent need for pharmacologic treatments targeting the molecular mechanisms driving ARDS pathog…
  • College: College of Medicine (COM)
  • Inventors: Karpurapu, Manjula; Christman, John; Parinandi, Narasimham
  • Licensing Officer: Willson, Christopher

Unveiling Unreported Pain: A Systematic Approach for Enhanced Patient Care
TS-064835 — The Need In healthcare, accurately assessing and managing pain is paramount for patient well-being and treatment efficacy. However, conventional methods of pain assessment rely heavily on verbal communication from patients, which poses challenges for individuals unable to express their pain verball…
  • College: College of Nursing
  • Inventors: Monroe, Todd
  • Licensing Officer: Taysavang, Panya

Intracellular Targeting by Monoclonal Antibodies
TS-064581 — Antibodies are essential therapeutic modalities for treating a plethora of different diseases, ranging from cancer, autoimmune disorders, degenerative diseases, and inflammation. The FDA approved the first antibody over three decades ago, and since more than 570 have been studied in clinical trials,…
  • College: College of Arts & Sciences
  • Inventors: Magliery, Thomas; Do, Jamie; Han, Jeong Min "Mina"; Zhu, Ian
  • Licensing Officer: Dahlman, Jason "Jay"

Magnetic Nanoparticles for Cancer Cell Classification
TS-064577 — Glioblastoma (GBM) is the most common malignant brain tumor accounting for 47.7% of all brain cancers. Unfortunately, treatments are limited, and survival is poor, with approximately only 40% living past the first-year post-diagnosis and 17% in the second year. The Need Developing drugs for cance…
  • College: College of Arts & Sciences
  • Inventors: Schultz, Zachary; Rist, David; Skardal, Aleksander; Venere, Monica
  • Licensing Officer: Panic, Ana

Utilizing WT-IV-012 to improve immune checkpoint therapy in cancer treatment
TS-064262 — The Need Addressing the limitations of current melanoma therapies, there exists a critical need for innovative approaches that enhance the effectiveness of immune checkpoint therapeutics. Despite advancements in immunotherapy, a significant percentage of melanoma patients do not achieve complete re…
  • College: College of Arts & Sciences
  • Inventors: Burd, Craig; Aguilar-Valenzuela, Renan; Burd, Christin
  • Licensing Officer: Panic, Ana

Multimeric Notch ligands based on IgM-like fusion molecular structures for activation of ligand-specific Notch signaling
TS-064248 — The Notch signaling pathway is important in immune cell differentiation and maturation. As a result, it has been shown that Notch receptor signaling can promote or suppress adaptive immune responses depending on the particular ligands and receptors involved. A set of native protein-inspired biolog…
  • College: OSU Wexner Medical Center
  • Inventors: Dikov, Mikhail; Carbone, David; Goruganthu, Uttam Lakshmi Mounika; Tchekneva, Elena
  • Licensing Officer: Willson, Christopher

How Are You Feeling Today? Organizational Mental Health Indicator and Real-Time Help Application
TS-064244 — The Need: Organizations, particularly college campuses, are facing a growing challenge in addressing student mental health issues. The rising prevalence of severe psychological problems, anxiety disorders, and depression among students necessitates a proactive and effective solution. The existing ga…
  • College: College of Engineering (COE)
  • Inventors: Ezell, Jonathan; Kaufman, Michael
  • Licensing Officer: Dahlman, Jason "Jay"

CDP-choline a host-directed therapeutic for disease caused by SARS CoV-2 infection.
TS-064192 — The Need: The global impact of the SARS CoV-2 coronavirus has created an urgent need for innovative medical interventions to address the challenges posed by COVID-19. Despite the availability of vaccines, sub-optimal vaccine uptake and concerns about new virus variants necessitate additional medical…
  • College: College of Veterinary Medicine
  • Inventors: Davis, Ian; Schelhorn, Jean
  • Licensing Officer: Willson, Christopher

Introducing HexaPro VSV: A Breakthrough in COVID-19 Vaccine Technology
TS-064191 — The emergence of SARS-CoV-2 variants poses a significant challenge to existing COVID-19 vaccines, necessitating the development of a more durable and broadly protective solution. Current vaccines show reduced efficacy over time and struggle against Variants of Concern (VoCs) such as Omicron. Addre…
  • College: College of Veterinary Medicine
  • Inventors: Li, Jianrong; Chamblee, Michelle; Lu, Mijia; Zhang, Yuexiu
  • Licensing Officer: Willson, Christopher

A new diagnostic assay for classic galactosemia
TS-064133 — Classic galactosemia is a genetic condition that can lead to life-threatening complications, including feeding problems, failure to thrive, liver damage, bleeding, and sepsis. If a lactose-restricted diet is provided during the first ten days of life, the neonatal symptoms quickly resolve and reduce…
  • College: College of Arts & Sciences
  • Inventors: Gopalan, Venkat; Bashian, Eleanor; Thirugnanasambantham, Pankajavalli
  • Licensing Officer: Panic, Ana

Skin Healing Technology: Dermal Substitutes and Engineered Skin with Rete Ridges
TS-064046 — Dermal substitute with engineered rete ridges improves epidermal-dermal communication and enhances burn wound treatment.
Massive burn injuries present a critical challenge in wound healing and prevention of infection. Current treatment methods are susceptible to blistering and other problems that can reduce engraftment. The Need Cultured epithelial autografts (CEAs) are a vital component in treating large burns, but…
  • College: College of Engineering (COE)
  • Inventors: Powell, Heather; Bailey, John; Blackstone, Britani "Niki"
  • Licensing Officer: Willson, Christopher

Adjustable Squatting Device for Constipation
TS-063959 — The Need Millions of individuals suffer from constipation due to the inability to relax pelvic floor muscles during bowel movements, leading to discomfort and strained efforts. Current solutions, like the Squatty Potty, lack adjustability and portability, limiting their effectiveness for a diverse …
  • College: College of Engineering (COE)
  • Inventors: Ruegsegger, Mark; Chakraborty, Subhankar; Gluzman, Isabella; Li, Yiqun; Piatkowski, Stephen; Puri, Raima
  • Licensing Officer: Bhatti, Hamid

Endoscopic additive manufacturing of biomaterials
TS-063919 — An articulating end effector for additive manufacturing that utilizes robot-assisted endoscopic surgery to implant synthetic tissues at local defects through “keyhole” incisions in patients. This innovative technology T2019-145 is part of a portfolio that also includes T2017-363. To learn more about both technologies, please visit https://oied.osu.edu/find-technologies and search using the phrase: Endoscopic additive manufacturing of biomaterials.
Robot-assisted surgery, tissue engineering, and additive manufacturing (AM) are emerging techniques in healthcare. Currently AM is used to develop synthetic tissues and organs, but open surgery is typically used to implant these scaffolds within the patient. This invasive procedure can subject pat…
  • College: College of Engineering (COE)
  • Inventors: Hoelzle, David; Asghari Adib, Ali; D'Souza, Desmond; Mansour, Daniel; Simeunovic, Andrej
  • Licensing Officer: Zinn, Ryan

Novel STK1-targeted small molecule "antibiotic resistance breaker" compounds
TS-063547 — Novel small molecule STK1 inhibitors that “break” the resistance of bacteria strains to antibiotics.
In today’s healthcare landscape, increasingly highly pathogenic and multidrug-resistant S. aureus (MDRSA) strains are replacing traditional methicillin-resistant S. aureus (MRSA) in both community and hospital settings. The Need The rise of these resilient multi-drug resistant bacteria has …
  • College: College of Medicine (COM)
  • Inventors: Pancholi, Vijay
  • Licensing Officer: Willson, Christopher

Protecting the vascular endothelial barrier – a novel approach to treating atrial fibrillation
TS-063433 — A new pharmacologic modality for treating AFib.
Atrial fibrillation (AF) is the most common form of irregular cardiac rhythm (arrhythmia), affecting approximately 3% of the US population. It is a significant risk factor for heart failure, ischemic stroke, and sudden cardiac death. The AF mortality rate is growing globally, and risk factors known …
  • College: College of Engineering (COE)
  • Inventors: Veeraraghavan, Rengasayee; Mezache, Louisa
  • Licensing Officer: Willson, Christopher

Convolutional Neural Network to Assess Phayngeal and Laryngeal Pathology and Function on Nasopharyngolaryngoscopy
TS-063154 — Worldwide, 686,000 new head and neck (H&N) cancers are diagnosed yearly, and 375,000 people will die annually. Human papillomavirus (HPV) is responsible for an increasing subset of H&N malignancies called oropharyngeal squamous cell carcinomas (OPSCC). Although it has a better prognosis than…
  • College: College of Engineering (COE)
  • Inventors: Krening, Samantha; Gifford, Ryan; Jhawar, Sachin; VanKoevering, Kyle
  • Licensing Officer: Hampton, Andrew

Gene Therapy Compositions for Treating Cardiovascular Diseases
TS-063091 — A gene therapy approach to address the specific needs of failing hearts.
Heart failure affects over 6 million adults in the US and can lead to irreversible damage to the heart. The Need In the realm of cardiovascular health and the management of heart-related disorders, there exists a pressing commercial need for a technology that can effectively address the challenge…
  • College: College of Medicine (COM)
  • Inventors: Lewandowski, E. Douglas; Carley, Andrew
  • Licensing Officer: Willson, Christopher

Thermotropic liquid crystal-based sensors for naked-eye detection of SARS-CoV-2 with ultrahigh sensitivity and selectivity
TS-063069 — In the wake of the global pandemic caused by SARS-CoV-2, the need for rapid, accurate, and efficient diagnostic methods for respiratory viral infections has become more critical than ever. Traditional diagnostic methods, while reliable, are often time-consuming, labor-intensive, and lack the neces…
  • College: College of Engineering (COE)
  • Inventors: Wang, Xiaoguang; Qin, Rongjun; Rather, Adil; Xu, Yang
  • Licensing Officer: Randhawa, Davinder

Automated Endotracheal Intubation
TS-062900 — This cutting-edge technology redefines the intubation process by guiding the endotracheal tube into the airway with exceptional precision.
The Need Intubation is a critical medical procedure used to assist patients with breathing difficulties, executed through the insertion of an endotracheal tube (ET) into the windpipe. With over 313 million annual intubation procedures worldwide, ensuring first-pass success and minimizing complicati…
  • College: College of Engineering (COE)
  • Inventors: Ruegsegger, Mark; Elsayed-Awad, Hamdy; Hopping, Ethan; Lopez Vogler, Christian; Miles, Tim; Peiffer, Jordan
  • Licensing Officer: Bhatti, Hamid

Dual-payload Humanized Antibody-Drug Conjugate (DualADC) for targeted chemo-immunotherapy
TS-062822 — Dual payload ADC chemo-immunotherapy and Humanized mAb for cancer treatment
The Liu Lab Dr. Xiaoguang “Margaret” Liu applies her industry experience (Lonza, Merck, and Life Technologies) in cell line and process development towards her lab’s focus on targeted anti-cancer therapies including monoclonal antibodies, antibody-drug conjugates, and gene ther…
  • College: College of Engineering (COE)
  • Inventors: Liu, Xiaoguang "Margaret"; Zhou, Lufang
  • Licensing Officer: Schworer, Adam

Transforming PAH Management with PHORA: Empowering Physicians for Better Patient Care
TS-062764 — The Pulmonary Hypertension Outcomes Risk Assessment (PHORA): a PAH risk stratification tool.
Pulmonary Arterial Hypertension (PAH) demands precise risk stratification for effective patient management. Clinical decision support tools can help inform treatment decisions made by physicians and other healthcare providers, usually at the point of care. The Need Current methods for assistin…
  • College: College of Medicine (COM)
  • Inventors: Benza, Ray; Lin, Shili; Mathur, Puneet
  • Licensing Officer: Hampton, Andrew

Unlocking New Frontiers in Diabetic Retinopathy Detection: Introducing Vessel Orientation-Based Quantitative OCTA Technology
TS-062762 — Pinpointing previously concealed sectoral differences in the diabetic retina to diagnose DR earlier.
Diabetic Retinopathy (DR) is a leading cause of blindness globally, requiring early and accurate diagnosis for effective intervention. The Need Current diagnostic methods for DR lack the precision needed to identify subtle retinal microvascular changes in the disease’s early stages. There i…
  • College: College of Medicine (COM)
  • Inventors: Ma, Yanhui
  • Licensing Officer: Willson, Christopher

A Breakthrough in Central Nervous System Repair
TS-062739 — Method to program pericytes for axon regeneration and spinal cord injury repair.
In the realm of central nervous system (CNS) repair, a critical need arises for innovative treatments that not only address the physical aspects of injury but also tackle the associated phychopathology. Understanding the cellular processes that occur after spinal cord injury (SCI) that are detrimen…
  • College: College of Medicine (COM)
  • Inventors: Tedeschi, Andrea
  • Licensing Officer: Willson, Christopher

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