TS-076823 — Solar-blind UV detection (200–280 nm) is essential across defense, fire detection, secure optical communications, environmental monitoring, and space applications. Existing solutions — photomultiplier tubes and filtered silicon photodetectors — are bulky, fragile, require high op…

TS-076675 — Indoor moisture and mold remain persistent challenges for residential, commercial, healthcare, and institutional buildings. Existing mold assessment methods often measure the presence of fungal species or biomass but struggle to distinguish active mold growth from normal background microbial popul…

TS-076603 — High-Stability Junctions for Next-Gen Chips

TS-076602 — The Bio-inspired MOF Advantage

TS-076593 — Light olefins are essential feedstocks for polymers and other high-value chemicals, but conventional alkane dehydrogenation is energy-intensive and constrained by reaction equilibrium. High operating temperatures can reduce selectivity, accelerate catalyst degradation, and promote unwanted byprodu…

TS-076584 — A drone-enabled technology for auditing irrigation performance across golf courses, athletic fields, agricultural land, parks, and other managed landscapes. The system combines aerial sensor data with geospatial mapping and intelligent analysis to generate visual irrigation-audit maps and indicators of water-distribution uniformity and system efficiency. This approach may reduce the time and field labor required for conventional irrigation audits while helping users identify uneven watering and irrigation components that may need attention.

TS-076541 — Ga2O3 ultraviolet photodetectors are increasingly being deployed in applications such as water purification, industrial process monitoring, environmental sensing, defense systems, and advanced manufacturing. However, many emerging wide-bandgap photodetector technologies exhibit nonlinear responses…

TS-076522 — Manufacturers across aerospace, energy, transportation, and advanced manufacturing sectors require reliable methods to inspect critical components without destructive testing. Conventional ultrasonic inspections often provide only bulk through-thickness information, making it difficult to isolate …

TS-076401 — Many progressive diseases, including cardiac, neurological, and other chronic disorders, begin with subtle molecular and cellular changes long before conventional clinical signs become detectable. Current diagnostic approaches generally identify disease only after significant tissue remodeling or …

TS-076338 — PCL has been a key material in modern medicine and advanced medical device manufacturing. Able to degrade away slowly in the body without producing toxic residues, PCL has been used for medical implants and controlled drug release over time. However, PCL is inherently hydrophobic and has set degra…

TS-076325 — UV LEDs, particularly those operating at shorter wavelengths, face persistent challenges in achieving high optical efficiency. Conventional device architectures can suffer from significant internal absorption and inefficient light extraction, limiting wall-plug efficiency and increasing power requ…

TS-076286 — Literature shows that Negative Pressure Wound Therapy (NPWT) combined with fluid instillation can improve abdominal trauma patient outcomes. Current standards of practice are inefficient, involving assembly and off-label use of at least 8 medical products. This is further complicated by varied pro…

TS-076198 — Advanced photonic systems for communications, sensing, computing, and quantum technologies increasingly rely on lithium niobate due to its exceptional electro-optic and nonlinear optical properties. However, existing high-performance lithium niobate photonic devices face major commercialization ba…

TS-076188 — Polypropylene (PP) is an attractive engineering polymer due to its low cost, recyclability, chemical resistance, and favorable processing characteristics. However, conventional PP is notoriously difficult to foam because of its low melt strength and highly crystalline structure, often resulting in…

TS-076137 — Heavy-duty trucks consume significant fuel during highway operation, with aerodynamic drag representing a major source of energy loss and operating expense. As fleet operators face increasing pressure to reduce fuel costs, improve vehicle efficiency, and lower emissions, there is a growing need fo…

TS-076055 — Microplastics and, increasingly, nanoplastics, are emerging contaminants of concern in water systems, consumer products, and environmental samples. However, most existing analytical workflows are optimized for larger particles and often fail to reliably isolate, quantify, and identify plastics in …

TS-076011 — Fiber reinforced polymer (FRP) reinforcement is increasingly being adopted in infrastructure and construction applications due to its corrosion resistance and durability. However, joining or terminating these reinforcement elements remains a significant challenge. Many established coupling and anc…

TS-075868 — Clinicians managing pediatric patients supported by a ventricular assist device must routinely assess pump performance by visually estimating membrane fill and ejection during pump cycles. These evaluations are critical for patient management but are inherently subjective, time-consuming, and pron…

TS-075845 — Drug discovery, biologics development, cell therapy research, and advanced in vitro testing all rely on large numbers of cell-based experiments. While continuous perfusion can improve biological relevance by maintaining nutrient availability, removing waste products, and better mimicking physiolog…

TS-075834 — Indoor moisture and mold exposure remain significant challenges for building owners, environmental testing providers, and public health stakeholders. Existing detection methods often focus on visible contamination, microbial growth, or genetic signatures, but they may not directly measure biologic…

TS-075755 — Electrification of high-power off-highway equipment remains challenging due to highly variable operating conditions, unpredictable duty cycles, demanding torque requirements, and limited charging infrastructure. Conventional energy management approaches often struggle to balance fuel efficiency, b…

TS-075750 — Agricultural tractors operate under highly variable conditions that make power demand, fuel consumption, and equipment performance difficult to predict. Differences in soil characteristics, terrain, field layouts, implements, and operator practices can cause substantial variability in energy use, …

TS-075721 — Transportation manufacturers continue to face increasing pressure to improve vehicle energy efficiency, extend electric vehicle range, and reduce emissions without adding significant cost, weight, or system complexity. While passive aerodynamic features such as strakes and deflectors are commonly …

TS-075686 — The rapid growth of AI training and high-performance computing workloads is driving chip power densities beyond the capabilities of many conventional cooling approaches. Data center operators face a difficult tradeoff between supporting next-generation high-power processors and controlling the sub…

TS-075663 — High-power laser systems, advanced sensing platforms, and emerging photonic architectures increasingly require optical fibers capable of operating across challenging wavelength regimes and extreme power densities. However, many high-performance crystalline fiber materials are difficult to process …

TS-075637 — Microfluidic and organ-on-chip platforms are gaining importance in drug discovery, toxicity testing, diagnostics, and advanced biological research. However, widespread adoption remains constrained by the difficulty of connecting microscale devices to conventional fluid delivery hardware. Existing …

TS-075600 — Incremental forging offers manufacturers a flexible route to produce near-net-shape components without dedicated dies, but process planning remains highly dependent on operator expertise, trial-and-error development, and time-consuming programming. As part geometries become more complex, determini…

TS-075588 — As federated learning expands across IoT, industrial, automotive, and connected-device ecosystems, maintaining reliable model training on energy-constrained edge devices remains a major challenge. Many devices operate on limited batteries or intermittent harvested energy, making continuous partici…

TS-075552 — The battery industry is under increasing pressure to develop cathode materials that deliver higher energy density while reducing reliance on expensive and supply-constrained metals such as cobalt and nickel. Cation-disordered rock-salt (DRX) cathodes have emerged as promising candidates due to the…

TS-075528 — Flying-disc activities are enjoyed across sports, recreation, pet training, and adaptive athletics, yet participants often rely on a second person to provide consistent throws. This limits opportunities for independent practice, recreational play, and accessibility for individuals with mobility li…

TS-075519 — A galactose-based RAFT chain transfer agent (Gal-RAFT) that incorporates a sugar moiety at the polymer terminus, enabling the synthesis of well-defined polymers with an integrated carbohydrate handle for subsequent biological applications.

TS-075512 — Organizations invest substantial resources in employee training and professional development, yet many struggle to demonstrate a clear connection between training expenditures, workforce performance, and career advancement. Human resources teams often lack effective tools to identify specific skil…

TS-075489 — Organizations across healthcare, government, finance, market intelligence, and regulatory sectors routinely generate large collections of reports containing valuable tabular data. While these reports often follow consistent formats, extracting, comparing, and analyzing information across multiple …

TS-075450 — Safety-critical systems in industries such as energy, aerospace, industrial automation, and advanced manufacturing are becoming increasingly complex, integrating hardware, software, controls, sensors, and communication networks. Existing fault analysis methods are often domain-specific and require…

TS-075425 — Many vehicle-based transactions and automated services rely on proximity technologies such as RFID, NFC, GPS, or license plate recognition. These approaches can struggle with lane-level accuracy, require dedicated hardware installed on vehicles, or are vulnerable to misidentification when multiple…

TS-075262 — PROBLEM Alzheimer’s disease is a progressive brain disorder that destroys memory and thinking, affecting 6–7 million people in the U.S. and over 50 million worldwide. There is currently no cure, and available treatments only temporarily manage symptoms or modestly slow disease progressi…

TS-075261 — Problem Hemolysis, the process by which the red blood cell membrane ruptures, releasing hemoglobin (Hb), is typically managed in mammalian organisms by intrinsic proteins such as hemopexin (Hpx) and haptoglobin (Hp). However, their concentrations in plasma are very limited, so, in conditions with s…

TS-075260 — Problem Type 2 diabetes and related metabolic disorders affect hundreds of millions of patients and are frequently accompanied by chronic inflammation, which accelerates disease progression and complications. Existing antidiabetic therapies often fail to adequately address inflammatory pathways and…

TS-075259 — More than a billion people worldwide suffer from some form of neurological disorder, such as Alzheimer's (AD), Parkinson's (PD), multiple sclerosis, traumatic brain injury, epilepsy, stroke, or spinal injury. These conditions result in more than 7 million deaths, with associated costs exceed…

TS-075258 — PROBLEM Chronic heart failure following myocardial infarction (MI) afflicts ~6.7 million US adults and is driven by maladaptive immune activation, particularly persistent activation and proliferation of CD4+ T cells. Existing anti-inflammatory and immunomodulatory approaches have largely failed to …

TS-075255 — Problem The limited regenerative capacity of adult CNS neurons upon transection results in chronic neurological disability. There is an urgent need to develop novel therapies that facilitate CNS axon regeneration and ultimately restore lost neurological functions. Solution Applications Advan…

TS-075254 — Problem Cardiomyopathy weakens the heart muscle and impairs its ability to pump blood effectively, often leading to heart failure or sudden cardiac death. While doxorubicin remains an essential component of many cancer regimens, its use is limited by the risk of causing lethal cardiomyopathy. A maj…

TS-075248 — Problem High-grade serous ovarian cancer (HGSOC) accounts for over 75% of all epithelial OC and has a high mortality rate due to a lack of early detection methods. Current biomarkers have low sensitivity and specificity in early-stage disease. There is an urgent need for a more effective diagnosis …

TS-075247 — PROBLEM Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ damage, affecting women at a 9:1 rate as compared to men. The etiology of SLE is complex and incompletely understood; however, the susceptibility of women during the years in which estrogen levels ar…

TS-075246 — Problem Peripheral neuropathy, especially small fiber neuropathy, is a debilitating condition that affects millions and is commonly linked to aging, diabetes, and metabolic disorders. Existing diagnostic tools are often invasive, expensive, or they lack the sensitivity to detect early disease stage…

TS-075245 — Problem Although cyclin dependent kinase 9 (CDK9) is a promising drug target, traditional small-molecule inhibitors face challenges due to CDK9's structural similarities with other kinases, leading to off-target effects and limited efficacy Solution Applications Advantages Seeking opp…

TS-075244 — Problem Acute myeloid leukemia (AML), the most common acute leukemia in adults, is a clinically and molecularly heterogeneous disease. Sequencing of large patient cohorts has uncovered a complex mutational landscape in AML but still fails to completely explain the biological and clinical heterogene…

TS-075243 — Problem Central nervous system (CNS) injury can result in permanent neurological disability and vision loss. There is a dire need to develop novel therapies that overcome barriers to repair within the CNS and promote neuron survival and axon regeneration. Solution Applicat…

TS-075242 — THE PROBLEM Although immune checkpoint blockade (ICB) has emerged as promising cancer immunotherapy, many tumors fail to respond to ICB. This failed response is often driven by the activation of TGF-β1 in the tumor microenvironment (TME), which induces regulatory T cells and inhibits the funct…

TS-075241 — Problem Cardiovascular diseases (CVDs) such as heart failure, myocardial infarction, and cardiomyopathies remain leading causes of death worldwide. Notably, heart failure is the only major cardiovascular condition still increasing in prevalence. Current treatments primarily consist in managing the …