# of Displayed Technologies: 9 / 9


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ReScribe: Transcription factors for reprogramming of diseased musculoskeletal related cells
TS-046978 — Transcription factors that can upregulate desired genes in diseased tissue to reprogram diseased cells, thereby reversing the disease and creating healthy non-diseased phenotype genes. These transcription factors would be especially useful in musculoskeletal diseases such as back pain and osteoarthritis.
Musculoskeletal diseases including osteoarthritis and chronic low back pain, are debilitating, painful, and often difficult to treat. Intervertebral disc (IVD) degeneration, as an example, is strongly associated with low back pain, a leading cause of disability worldwide. According to the American…
  • College: College of Engineering (COE)
  • Inventors: Walter, Devina; Gallego Perez, Daniel; Higuita Castro, Natalia; Hoyland, Judith; Khan, Safdar; Tang, Shirley "Shirley Nina"; Walter, Benjamin
  • Licensing Officer: Aanstoos, Megan

Apoprotein manufacturing and methods for protein purification
TS-046794 — Methods of purifying proteins that can be used in various applications such as drug delivery and detoxification of byproducts of hemolysis.
Novel protein and apoprotein purification strategies are valuable tools with a wide variety of medical and research applications. While there are existing techniques for protein and apoprotein purification, some of these have flaws such as the use of harsh denaturants, highly flammable solvents, l…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Belcher, Donald; Palmer, Andre
  • Licensing Officer: Aanstoos, Megan

Therapeutic uses of the apohemoglobin-haptoglobin complex
TS-046454 — Original, synthetic complexes used to detoxify hemoglobin, heme, and free iron in patients suffering from hemolysis. The use of these complexes would allow effective treatment of various states of hemolysis and would mitigate the numerous side effects associated with the condition. Complexes could also be used as a drug carrier for targeting CD163+ macrophages and monocytes.
Hemolysis is a burgeoning health condition that results from various pathophysioloigical conditions. It is characterized by the rupture of red blood cells, which release toxic, cell-free hemoglobin into the bloodstream. The cell-free hemoglobin further break down into heme and apoglobin, which cau…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Palmer, Andre
  • Licensing Officer: Aanstoos, Megan

Louie: An Augmented Reality Sensory Trigger Wayfinding System for People with Autism
TS-043077 — An Augmented Reality Sensory Trigger Wayfinding System for People with Autism
Millions of people on the Autism spectrum face challenges getting from place to place due to sensory sensitivities to sounds, sights, smells, tastes, physical feelings, and crowds. Due to these triggers, people with Autism have a strong need to know where they are going and what will be there so t…
  • College: College of Engineering (COE)
  • Inventors: Ezell, Jonathan; Kaufman, Robert; Kaufman, Michael
  • Licensing Officer: Aanstoos, Megan

Separation of Small Hydrophobic Ligands from Proteins via Tangential Flow Filtration
TS-040370 — Novel strategy to separate hydrophobic ligands from proteins through the use of Tangential Flow Filtration in which efficiency, safety, and scalability are improved. Enhanced production of proteins in this native state holds promise both for improved research and biomedical applications.
Successfully isolating proteins in their non-liganded state (i.e. apoprotein form) allows for an in-depth study of proteins from a research perspective. From an application standpoint apoproteins hold tremendous promise as both potential therapeutics and as drug delivery vehicles given their natur…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Belcher, Donald; Palmer, Andre
  • Licensing Officer: Aanstoos, Megan

Identifying the level of lupus patients’ comprehension of their medication regimens and disease outcomes
TS-040132 — A questionnaire used to understand a patient’s comprehension of their personalized medication plan and the disease fluctuation of systemic lupus erythematous (SLE).
Systemic lupus erythematous (SLE) is an autoimmune disease in which the body’s immune system attacks healthy tissue in its own body. The disease has a prevalance of twenty to 150 cases per 100,000 individuals, and is more common in females than in men. This chronic disease has no cure, and s…
  • College: College of Medicine (COM)
  • Inventors: Meara, Alexa; Ardoin, Stacy; Peters, Ellen
  • Licensing Officer: Aanstoos, Megan

Time Management Facilitator
TS-037366 — A novel device to reinforce the abstract concept of time to intellectually disabled children, especially those with Down syndrome.
Learning and understanding the abstract and intangible concept of time is especially difficult for children with Down Syndrome. This difficulty can cause deep frustration because it affects the family’s daily routine and reduces the child’s independence in the home, at school, and even…
  • College: College of Engineering (COE)
  • Inventors: Rogers, Peter "Peter"; Alley, Krista; Cornelius, Kristen; Dew, Elise; Hegedus, Alexander; Johnson, Kyle; Shiroma, Cecilia; Weisbecker, Carolyn; Whitehouse, Katherine
  • Licensing Officer: Aanstoos, Megan

Joint Stability Measurement Device for Total Knee Arthroplasty
TS-015289 — A device to intra-operatively measure varus/valgus, internal/external, and anterior/posterior stability for total knee arthroplasty
Total knee arthroplasty (TKA) is performed to relieve pain and disability associated with degenerative joint disease. Joint instability remains a leading cause of revision surgery following TKA. During the surgery, indicators of stability such as joint space are used to balance the knee. Many devi…
  • College: College of Engineering (COE)
  • Inventors: Siston, Robert; Maack, Thomas; Maack, Horst; Van Gorp, Cornel
  • Licensing Officer: Aanstoos, Megan

Stretchable and Flexible E-Fiber Wire Antennas
TS-014971 — A new process to fabricate stretchable and flexible wire antennas with conductive fibers (E-fibers)
Current processes to manufacture flexible, mechanically durable antennas on E-fibers yield non-stretchable prototypes and lack fine print details. The geometric accuracy of printed antennas is less than 1 mm, and the devices are prone to failure due to fatigue and wear from deformation. The antenn…
  • College: College of Engineering (COE)
  • Inventors: Volakis, John; Kiourti, Asimina
  • Licensing Officer: Aanstoos, Megan

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