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Gene delivery to adipose tissue using novel recombinant adeno-associated viral vectors
TS-037310 — An engineered recombinant adeno-associated virus capable of targeting fat tissue previously inaccessible to this viral vector for the purposes of genetic manipulation.
Recombinant adeno-associated viruses (rAAVs) are effective tools for delivering gene therapy treatment and for manipulation of acquired diseases. However, there is no effective method to target adipose tissue and transduction efficiency is low in naturally occurring AAV serotypes. In addition, cur…
  • College: College of Medicine (COM)
  • Inventors: Cao, Lei; Huang, Wei
  • Licensing Officer: Ezzell, Janel

Gene Therapy to Eliminate Obesity
TS-014969 — A one-time therapy that achieves life time results, corrects genetic obesity, and is independent of diet and exercise.
Obesity and the related condition, syndrome X (or metabolic syndrome) represent two of the most significant causes of morbidity in the western world and their incidences are growing rapidly. Lifestyle and non-pharmacologic approaches have limited efficacy, particularly in the morbidly obese. One s…
  • College: College of Medicine (COM)
  • Inventors: During, Matthew; Cao, Lei
  • Licensing Officer: Ezzell, Janel

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