Revolutionizing Pharmaceutical Synthesis: Advancements in Metal-Catalyzed Coupling Technology
TS-064824 — The Need
In the pharmaceutical industry, the synthesis of complex organic substrates is crucial for the development of life-saving medications. However, traditional metal-catalyzed coupling reactions often face significant challenges when applied to these complex substrates, leading to high failure…
- College: College
of
Arts
&
Sciences
- Inventors: Sevov, Christo; Dinh, Long; Hamby, Taylor; Starbuck, Hunter
- Licensing Officer: Willson, Christopher
Co-Axial Contained Electrospray Ionization Platform for Mass Spec.
TS-064299 — Mass spectrometry (MS) is used across a wide range of applications involving analytical chemistry. Various MS techniques, often coupled with liquid chromatography (LC), allow for detection of various chemical analytes, from drug metabolites, pesticides, food adulterants, and natural product extracts…
- College: College
of
Arts
&
Sciences
- Inventors: Badu-Tawiah, Abraham; Burris, Benjamin "Ben"; Grooms, Alex; Heiss, Derik; Kulyk, Dmytro
- Licensing Officer: Dahlman, Jason "Jay"
Column-free Purification of Recombinant Proteins
TS-064270 — Large-scale recombinant proteins in Gram-negative bacteria (i.e., E. coli) are of significant interest in recombinant protein/enzyme production. These proteins exhibit wide-ranging applications, including food and beverages, conversion of carbohydrates into fuel ethanol or biodiesel, components for …
- College: College
of
Arts
&
Sciences
- Inventors: Gopalan, Venkat
- Licensing Officer: Willson, Christopher
Method and device for determining virus titer by surface enhanced Raman scattering
TS-062346 —
The ability to rapidly identify and determine virus titer is of utmost importance in numerous biomedical applications, ranging from gene editing to pharmaceutical and vaccine development. In the context of lentiviruses, which are widely used for cell reprogramming in immunotherapies, knowing the e…
- College: College
of
Arts
&
Sciences
- Inventors: Schultz, Zachary; Morder, Courtney
- Licensing Officer: Willson, Christopher
Dual ligand systems for cross-coupling of challenging C(sp2) and C(sp3) electrophiles.
TS-059018 — An unusual series
of ligand exchange reactions establishes a dualcatalyst system for electroreductive alkyl-aryl cross-electrophile couplings
of previously incompatible substrate combinations.
Cross-electrophile coupling (XEC) reactions of aryl and alkyl electrophiles are desirable methodologies for C–C bond formation but are limited to specific substrate classes. Couplings of widely-available electrophiles such as aryl chlorides or triflates are currently unknown with any alkyl b…
- College: College
of
Arts
&
Sciences
- Inventors: Sevov, Christo; Hamby, Taylor
- Licensing Officer: Willson, Christopher
Transition Metal Free Alkyne Hydrogenation and Semihydrogenation Catalysts
TS-058577 — Novel, transition metal-free catalysts capable
of alkyne hydrogenation and semihydrogenation under modest conditions.
The Need
Numerous industrial processes require alkyne semihydrogenation or hydrogenation reactions. For example, hydrogenation is necessary for the industrial-scale synthesis vitamin A, the creation of high molecular weight polymers, and the processing of petroleum into functionally useful derivati…
- College: College
of
Arts
&
Sciences
- Inventors: Goldberger, Joshua; Hodge, Kelsey
- Licensing Officer: Willson, Christopher
Transition Metal Free Alkyne Hydrogenation and Semihydrogenation Catalysts
TS-048726 — Novel, transition metal-free catalysts capable
of alkyne hydrogenation and semihydrogenation under modest conditions.
The Need
Numerous industrial processes require alkyne semihydrogenation or hydrogenation reactions. For example, hydrogenation is necessary for the industrial-scale synthesis vitamin A, the creation of high molecular weight polymers, and the processing of petroleum into functionally useful derivati…
- College: College
of
Arts
&
Sciences
- Inventors: Goldberger, Joshua; Hodge, Kelsey
- Licensing Officer: Willson, Christopher
Development of a Single Component Methacrylate Adhesive Formulation
TS-042066 — A novel hybrid adhesive that combines the non-toxic, high strength properties
of methacrylate adhesives with the bonding characteristics
of polyurethanes
Despite the utility of methacrylate adhesive chemistry, applications have been limited to industrial and biomedical use cases. This is due to the curing mechanism, which is initiated by either heat, light or a two-component redox system. This invention describes two strategies to create a single-c…
- College: College
of
Arts
&
Sciences
- Inventors: Parquette, Jonathan; Schricker, Scott
- Licensing Officer: Dahlman, Jason "Jay"
Porous inorganic-organic material for removal of trace carbon dioxide from air or other gas streams
TS-041747 — Adsorbent for carbon dioxide capture with low energy input for regeneration, and high adsorption capacity
46% of 2010 global greenhouse gas emissions came from electricity and heat production, or from fossil fuels burned for industrial use (EPA). A lot of effort has been put into research on CO2 capture by adsorbents or absorbents, in order to reduce these greenhouse gas emissions. Additionally, effec…
- College: College
of
Arts
&
Sciences
- Inventors: Wade, Casey; Bien, Caitlin
- Licensing Officer: Dahlman, Jason "Jay"
Method for Connectorizing Superconducting NbTi Coaxial Cables
TS-040418 — A fast and inexpensive electroplating technique for producing a connector attachment matching the structural and electrical properties
of standard coaxial cables for cryogenic applications.
Experiments performed at cryogenic temperatures much below the 4.2 K of liquid helium frequently require superconducting coaxial cables to efficiently transmit high frequency signals while minimizing heat transfer to the experiment’s cold stage. These cables are most often made of niobium-ti…
- College: College
of
Arts
&
Sciences
- Inventors: DeBry, Kyle; Lafyatis, Gregory
- Licensing Officer: Dahlman, Jason "Jay"
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