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Apoprotein manufacturing and methods for protein purification
TS-046794 — Methods of purifying proteins that can be used in various applications such as drug delivery and detoxification of byproducts of hemolysis.
Novel protein and apoprotein purification strategies are valuable tools with a wide variety of medical and research applications. While there are existing techniques for protein and apoprotein purification, some of these have flaws such as the use of harsh denaturants, highly flammable solvents, l…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Belcher, Donald; Palmer, Andre
  • Licensing Officer: Aanstoos, Megan

Separation of Small Hydrophobic Ligands from Proteins via Tangential Flow Filtration
TS-040370 — Novel strategy to separate hydrophobic ligands from proteins through the use of Tangential Flow Filtration in which efficiency, safety, and scalability are improved. Enhanced production of proteins in this native state holds promise both for improved research and biomedical applications.
Successfully isolating proteins in their non-liganded state (i.e. apoprotein form) allows for an in-depth study of proteins from a research perspective. From an application standpoint apoproteins hold tremendous promise as both potential therapeutics and as drug delivery vehicles given their natur…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Belcher, Donald; Palmer, Andre
  • Licensing Officer: Aanstoos, Megan

Methods for Making Three Dimensional Microfluidic Bioreactor Array
TS-037642 — Design for a three-dimensional microfluidic bioreactor array; device allows for culturing of a variety of cell types without contamination.
Cell culture in a three-dimensional fluidic-flow microenvironment is critical for long-term cell-based assays. Conducting in vitro research offers an accessible, reproducible, and reliable mode of investigation for therapeutic decisions before work is conducted in vivo. However, because of the com…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Wen, Yuan
  • Licensing Officer: Davis, Stewart

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