— Measurement/detection of
analytes (e.g., biomarkers) in different environments (e.g., biof
luids/organs) is typically performed using a biosensor. Available bio-integrated sensors do not provide the capability to map biomarker concentrations, require a power source to function, use a limited number of
electrodes, and normally can only measure a specific type of
luid but not others. The use of
glutamate mapping technology (radioactive or fluorescent ligand bound to a glutamate receptor) has been evaluated and found to require bulky/expensive medical equipment, a power source for measurement, cannot be miniaturized or integrated into a bio tissue, and require patients to be stationary during measurement.
To address concerns and limitations with current biomarker detection/ measurement technologies, an alternative, cost-effective, efficient biosensing system/device capable of 2D/3D mapping the concentrations of various biomarkers in different bio environments is required.