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Humanized SSTR2 mAb and ADC to target SSTR2+ tumors
TS-066912 — Targeted humanized mAbs and ADCs for cancer treatment
The Liu Lab Dr. Xiaoguang “Margaret” Liu applies her industry experience (Lonza, Merck, and Life Technologies) in cell line and process development towards her lab’s focus on targeted anti-cancer therapies including monoclonal antibodies, antibody-drug conjugates, and gene therapi…
  • College: College of Engineering (COE)
  • Inventors: Liu, Xiaoguang "Margaret"; Zhou, Lufang
  • Licensing Officer: Schworer, Adam

Innovative Solutions for Cell Viability and Targeted Delivery
TS-066100 — Research tool to transfect cells ex vivo using electroporation through electrospun core-shell fibers for research applications
The Need: Conventional electroporation methods often result in low cell viability due to heat generation, especially when working with primary cells. These methods also face challenges with non-specific transport of molecules, high vector integration rates leading to mutagenesis, and inefficacy in …
  • College: College of Engineering (COE)
  • Inventors: Gallego Perez, Daniel; Das, Devleena; Duarte Sanmiguel, Silvia; Higuita Castro, Natalia
  • Licensing Officer: Schultz, Teri

System for automated high-speed imaging and genetic manipulation of C. elegans on agar media
TS-065892 — The Need The microscopic worm C. elegans is a model animal studied in more than 1500 biological and medical research laboratories worldwide due to its genetic manipulability and optical transparency. In C. elegans research, the manual process of picking worms between plates presents a significant …
  • College: College of Engineering (COE)
  • Inventors: Fang-Yen, Christopher "Chris"; Alhalbi, Serge; Li, Zihao
  • Licensing Officer: Randhawa, Davinder

Novel Therapeutic Approach to Treating Painful Musculoskeletal Disorders
TS-065684 — Non-viral gene therapy for minimally invasively treating painful musculoskeletal disorders
Painful musculoskeletal disorders like intervertebral disc (IVD) degeneration associated with chronic low back pain (DBP) present a significant socio-economic burden worldwide. The Need Current treatments for painful musculoskeletal disorders offer only temporary relief or invasive surgical proce…
  • College: College of Engineering (COE)
  • Inventors: Walter, Devina; Gallego Perez, Daniel; Higuita Castro, Natalia; Khan, Safdar; Tang, Shirley "Shirley Nina"; Walter, Benjamin
  • Licensing Officer: Schultz, Teri

Containment System for Heating and Off-Gassing
TS-065424 — Due to environmental concerns and the decreasing supply of fossil fuels, there is substantial demand for nuclear-based energy production. Nuclear energy now provides about 10% of the world's electricity from about 440 power reactors and is the second largest source of low-carbon power. In addition, over 50 smaller countries utilize nuclear energy in about 220 research-size reactors. These reactors are used to produce medical and industrial isotopes and several other purposes.
It is essential to meet the safeguard requirements in liquid-fueled molten salt reactors, fuel salt transportation, and fuel cycle processes and to develop effective methods for measuring and monitoring the mass of molten fuel salt or coolant salt. However, due to the complex and dynamic nature o…
  • College: College of Engineering (COE)
  • Inventors: Van Zile, Matthew; Cao, Lei Raymond; Kauffman, Andrew
  • Licensing Officer: Zinn, Ryan

Scalable Nanoparticle Synthesis for Precision Applications
TS-064181 — In the rapidly evolving landscape of nanotechnology, there exists a critical demand for scalable and efficient methods of producing nanoparticles. Current approaches, often confined to small-scale batches, hinder the widespread implementation of nanomaterials in diverse fields such as medicine, bi…
  • College: College of Engineering (COE)
  • Inventors: Winter, Jessica; Ruan, Gang
  • Licensing Officer: Dahlman, Jason "Jay"

Skin Healing Technology: Dermal Substitutes and Engineered Skin with Rete Ridges
TS-064046 — Dermal substitute with engineered rete ridges improves epidermal-dermal communication and enhances burn wound treatment.
Massive burn injuries present a critical challenge in wound healing and prevention of infection. Current treatment methods are susceptible to blistering and other problems that can reduce engraftment. The Need Cultured epithelial autografts (CEAs) are a vital component in treating large burns, but…
  • College: College of Engineering (COE)
  • Inventors: Powell, Heather; Bailey, John; Blackstone, Britani "Niki"
  • Licensing Officer: Schultz, Teri

Adjustable Squatting Device for Constipation
TS-063959 — The Need Millions of individuals suffer from constipation due to the inability to relax pelvic floor muscles during bowel movements, leading to discomfort and strained efforts. Current solutions, like the Squatty Potty, lack adjustability and portability, limiting their effectiveness for a diverse …
  • College: College of Engineering (COE)
  • Inventors: Ruegsegger, Mark; Chakraborty, Subhankar; Gluzman, Isabella; Li, Yiqun; Piatkowski, Stephen; Puri, Raima
  • Licensing Officer: Bhatti, Hamid

Endoscopic additive manufacturing of biomaterials
TS-063919 — An articulating end effector for additive manufacturing that utilizes robot-assisted endoscopic surgery to implant synthetic tissues at local defects through “keyhole” incisions in patients. This innovative technology T2019-145 is part of a portfolio that also includes T2017-363. To learn more about both technologies, please visit https://oied.osu.edu/find-technologies and search using the phrase: Endoscopic additive manufacturing of biomaterials.
Robot-assisted surgery, tissue engineering, and additive manufacturing (AM) are emerging techniques in healthcare. Currently AM is used to develop synthetic tissues and organs, but open surgery is typically used to implant these scaffolds within the patient. This invasive procedure can subject pat…
  • College: College of Engineering (COE)
  • Inventors: Hoelzle, David; Asghari Adib, Ali; D'Souza, Desmond; Mansour, Daniel; Simeunovic, Andrej
  • Licensing Officer: Zinn, Ryan

High-K Dielectric barriers to suppress internal photoemission photocurrents
TS-063471 — In an increasingly digital world, the demand for efficient and reliable photodetectors is paramount. These devices are critical for a variety of applications, from medical imaging to defense systems. However, traditional photodetectors often struggle with low UV-visible rejection, limiting their e…
  • College: College of Engineering (COE)
  • Inventors: Rajan, Siddharth; McGlone, Joseph "Joe"; Wriedt, Nathan
  • Licensing Officer: Zinn, Ryan

Protecting the vascular endothelial barrier – a novel approach to treating atrial fibrillation
TS-063433 — A new pharmacologic modality for treating AFib.
Atrial fibrillation (AF) is the most common form of irregular cardiac rhythm (arrhythmia), affecting approximately 3% of the US population. It is a significant risk factor for heart failure, ischemic stroke, and sudden cardiac death. The AF mortality rate is growing globally, and risk factors known …
  • College: College of Engineering (COE)
  • Inventors: Veeraraghavan, Rengasayee; Mezache, Louisa
  • Licensing Officer: Schultz, Teri

A Regularized Conditional GAN for Posterior Sampling in Inverse Problems
TS-063238 — A novel regularization technique applicable for medical imaging applications that leverages conditional generative adversarial networks (cGANs) to generate reconstructed images in significantly shorter timeframes. The Need Several techniques are used for image reconstruction in the medical aren…
  • College: College of Engineering (COE)
  • Inventors: Bendel, Matthew; Ahmad, Rizwan; Schniter, Philip
  • Licensing Officer: Hampton, Andrew

Convolutional Neural Network to Assess Phayngeal and Laryngeal Pathology and Function on Nasopharyngolaryngoscopy
TS-063154 — Worldwide, 686,000 new head and neck (H&N) cancers are diagnosed yearly, and 375,000 people will die annually. Human papillomavirus (HPV) is responsible for an increasing subset of H&N malignancies called oropharyngeal squamous cell carcinomas (OPSCC). Although it has a better prognosis than…
  • College: College of Engineering (COE)
  • Inventors: Krening, Samantha; Gifford, Ryan; Jhawar, Sachin; VanKoevering, Kyle
  • Licensing Officer: Hampton, Andrew

Automated Endotracheal Intubation
TS-062900 — This cutting-edge technology redefines the intubation process by guiding the endotracheal tube into the airway with exceptional precision.
The Need Intubation is a critical medical procedure used to assist patients with breathing difficulties, executed through the insertion of an endotracheal tube (ET) into the windpipe. With over 313 million annual intubation procedures worldwide, ensuring first-pass success and minimizing complicati…
  • College: College of Engineering (COE)
  • Inventors: Ruegsegger, Mark; Elsayed-Awad, Hamdy; Hopping, Ethan; Lopez Vogler, Christian; Miles, Tim; Peiffer, Jordan
  • Licensing Officer: Bhatti, Hamid

Dual-payload Humanized Antibody-Drug Conjugate (DualADC) for targeted chemo-immunotherapy
TS-062822 — Dual payload ADC chemo-immunotherapy and Humanized mAb for cancer treatment
The Liu Lab Dr. Xiaoguang “Margaret” Liu applies her industry experience (Lonza, Merck, and Life Technologies) in cell line and process development towards her lab’s focus on targeted anti-cancer therapies including monoclonal antibodies, antibody-drug conjugates, and gene ther…
  • College: College of Engineering (COE)
  • Inventors: Liu, Xiaoguang "Margaret"; Zhou, Lufang
  • Licensing Officer: Schworer, Adam

Tracking Breast Tissue Tumor Cavity after Lumpectomy
TS-062715 — Radiopaque biodegradable polymer for the tracking of the breast tissue tumor cavity after lumpectomy and other radiation therapy applications
Approximately 40% of women diagnosed with breast cancer undergo a lumpectomy procedure. Approximately 170,000 lumpectomie are performed each yaer in the United States. Typically, this operation is followed by radiation therapy to ensure there are no remaining cancerous cells in the region. It is t…
  • College: College of Engineering (COE)
  • Inventors: Metzler, Sandra; Elisha, Deji; Evans, Izzy; Fedro, Joseph; Krakovsky, Mia; Sherry, Adam; Skoracki, Roman
  • Licensing Officer: Zinn, Ryan

Purification of apoproteins and general methods for protein purification
TS-062540 — General methods for purifying proteins that can be used in various applications such as targeted drug delivery, bioimaging, and hemolysis treatment.
The Need Novel protein and apoprotein purification strategies are valuable tools with a wide variety of medical and research applications. While there are existing techniques for protein and apoprotein purification, some of these have flaws such as the use of harsh denaturants, highly flammable sol…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Cabrales, Pedro; Palmer, Andre
  • Licensing Officer: Schworer, Adam

Methods to measure biophysical attributes of the posterior eye
TS-062505 — The Need Glaucoma and myopia are significant causes of vision loss worldwide, affecting millions of people and imposing a substantial socioeconomical burden. Effective vision care strategies are urgently needed to reduce blindness caused by these conditions and mitigate their associated risks. In v…
  • College: College of Engineering (COE)
  • Inventors: Liu, Jun; Kwok, Sunny
  • Licensing Officer: Randhawa, Davinder

Methods for quantifying the biomechanical attributes of the cornea and the anterior sclera
TS-062497 — The Need: The field of ophthalmology requires advanced diagnostic tools to effectively diagnose, prevent, and treat various eye conditions. While ultrasound imaging is well-known in fields like pregnancy check-ups and vascular imaging, its potential in ophthalmology remains largely untapped. There …
  • College: College of Engineering (COE)
  • Inventors: Liu, Jun; Kwok, Sunny
  • Licensing Officer: Randhawa, Davinder

ANTENNA-IMPREGNATED FABRICS FOR RECUMBENT HEIGHT MEASUREMENT
TS-062493 — Children whose heights or growth rates fall outside of the normal range can be identified as having short stature (less than the 3rd percentile) or tall stature (above the 97th percentile) or as having abnormal growth velocity. Serial height measurements over time are key to identifying these patt…
  • College: College of Engineering (COE)
  • Inventors: Kiourti, Asimina; Militello, Lisa
  • Licensing Officer: Randhawa, Davinder

LRC-Circuit Based Smart Jewelry for Detection of Multiple Biomarkers in Sweat
TS-062489 — Biosensors are a powerful and emerging technology capable of measuring the presence and concentration of molecules inside the human body. These devices are based on the premise that the physiology of diseased tissue is substantially different from that of healthy tissue and can be used to diagnose a…
  • College: College of Engineering (COE)
  • Inventors: Li, Jinghua; Liu, Tzu Li
  • Licensing Officer: Ashouripashaki, Mandana

Venc Design and Velocity Estimation for Phase-Contrast MRI (Free-breathing Accelerated MRI Portfolio)
TS-062482 — Magnetic Resonance Imaging (MRI) is a versatile noninvasive imaging tool that is routinely used to evaluate many diseases and conditions. MRI offers exquisite soft tissue contrast and high spatial resolution to enable comprehensive structural and functional assessment of internal organs. Recent innovations in data acquisition and processing can expand the clinical applications of MRI.
The Need A major limitation of MRI is slow data acquisition, which can compromise patient comfort, drive up costs, and increase susceptibility to motion. The clinical adoption of volumetric imaging for musculoskeletal and neuro applications, the growing demand for free-breathing real-time imaging …
  • College: College of Engineering (COE)
  • Inventors: Zhao, Shen; Ahmad, Rizwan; Potter, Lee
  • Licensing Officer: Randhawa, Davinder

Localized Cylindrical Drug Delivery to Prevent Vascular Restenosis
TS-062216 — The Need: Addressing Vascular Restenosis with Extended Drug Delivery Vascular restenosis poses a significant medical challenge in the United States, particularly in cases of coronary artery disease treated with bypass grafting. The current methods involve using drug-loaded polymer formulations to d…
  • College: College of Engineering (COE)
  • Inventors: Lannutti, John
  • Licensing Officer: Dahlman, Jason "Jay"

Automatic Implanted Port Access Device
TS-061547 — A venous access port device that leverages near-field communication (NFC) to automate needle placement as well as a disposable needle cartridge to increase the ease of and help maintain aseptic access to the port.
Venous access ports are central venous access devices that allow healthcare practitioners easy access to the patient’s veins to give treatment and take blood. Typically, these ports are made of non-irritant material and can remain under the skin for weeks or months. The Need Accessing a …
  • College: College of Engineering (COE)
  • Inventors: Garcia, Jodi; Johnson, Trey; Purdom, Kellie; Weiss, Solomon; Weiss, Simon; Yuhasz, Ben
  • Licensing Officer: Bhatti, Hamid

An AI Solution for Mobile Stroke Detection for TeleMedicine, Hospital and Paramedic Use
TS-060782 — Problem Statement: Diagnosis of arterial occlusion and an associated stroke can be lengthy, delaying patient access to treatment. As large vessel occlusions account for 24 to 46% of acute ischemic strokes and may require treatment in a comprehensive stroke center, early diagnosis is key. Solution:…
  • College: College of Engineering (COE)
  • Inventors: Yilmaz, Alper; Gulati, Deepak Kumar
  • Licensing Officer: Hampton, Andrew

X-Ray Assistive Device for Standardizing the Knee Templating Process
TS-054471 — Knee templating is used as part of the pre-operative planning for knee replacement to determine the best fit for an implant. The current assistive devices used to determine fit are unreliable and inaccurate for proper patient fit. A new device is suggested to overcome these limitations.
Over 600,000 knee replacements are performed per year. As part of the pre-operative planning for surgery, x-ray images are taken to determine the proper fit for the implant. Even with the use of a calibration ball, this knee templating procedure remains inaccurate and unreliable for a number of re…
  • College: College of Engineering (COE)
  • Inventors: Ruegsegger, Mark; Aery, Dylan; Browske, Kimberly; Cantrell, Kaleb "Kaleb"; Reilman, Zach; Thew, Maddie
  • Licensing Officer: Randhawa, Davinder

Drug Delivery System for the Treatment of Neurological Diseases
TS-054464 — Novel drug delivery system that enables efficient transfer of FDA-approved drugs for the treatment of neurological injuries.
Traumatic brain and spinal cord injury cause devastating neurological deficits and long-term disability due to detrimental structural and functional alteration in neuronal circuits. Treatment of brain injury and neurological disorders has traditionally been challenging due to the inability to deli…
  • College: College of Engineering (COE)
  • Inventors: Lannutti, John; Fan, Fan; Tedeschi, Andrea
  • Licensing Officer: Schultz, Teri

Therapeutic uses of the scavenging protein cocktail to treat plasma protein imbalances or depletion
TS-053103 — Uncontrolled hemolysis (i.e., destruction of red blood cells) is characterized by the increase of circulating toxic cell-free hemoglobin, heme and iron in the bloodstream. In vivo, the body’s natural supply of plasma scavenger proteins acts to neutralize these toxic species. However, these scavenger proteins such as haptoglobin, hemopexin and transferrin, which detoxify hemoglobin, heme and iron, respectively, are depleted in various clinical conditions such as hemorrhagic shock, burns, surgery, organ transplantation, sepsis and trauma. Dr. Andre Palmer’s lab at The Ohio State University has developed a novel therapeutic protein mixture, which can be used to treat plasma protein imbalances or depletion caused by the adverse events described above. The properties of this protein mixture are beneficial as they lend themselves to an inexpensive manufacturing process and potential improvements in clinical outcomes.
Fluid replacement as part of resuscitation efforts in clinical care is a cornerstone of treatment especially in cases with severe trauma. The regular usage of these fluids in hospitals requires the mixture to be easily transported, easily stored and applicable across a wide variety of patients. To…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Palmer, Andre
  • Licensing Officer: Schworer, Adam

Pheno - A modern, multi-faceted, data-driven technology platform for addressing low back and neck pain
TS-052847 — Back and neck pain is one of the world’s biggest health problems, and one which most people will experience during some stage in their lives. An estimated 80% of people will face this issue, although the severity of the pain may differ. Approximately 50 billion USD are spent by Americans eac…
  • College: College of Engineering (COE)
  • Inventors: Marras, William; Aurand, Alexander "Alex"; Dufour, Jonathan; Knapik, Gregory; Prasath, Prasath Mageswaran
  • Licensing Officer: Hampton, Andrew

Smart Platform for Engineered Electroceutical Dressings (SPEEDs) Enables Better Wound Care
TS-050245 — An integrated platform with multiple sensing modalities to actively orchestrate antimicrobial activity and wound healing.
Wound healing and disinfection for chronic wounds presents significant hurdles within the medical industry. Current state of art is inadequate and adds a significant cost burden to the healthcare system with many health and life-quality challenges for patients. After the formation of an open wound…
  • College: College of Engineering (COE)
  • Inventors: Prakash, Shaurya; Heald, Rachel; Mohana Sundaram, Prashanth; Narayanan, Kavya; Stoodley, Paul; Subramaniam, Vishwanath; Vilku, Gurleen; Wilgus, Traci; Wozniak, Daniel
  • Licensing Officer: He, Panqing

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