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Papaverine Derivatives that are Effective Hypoxic Tumor Radiosensitizers
TS-041504 — Dr. Nicholas Denko and colleagues at The Ohio State University have developed papaverine derivatives that can be used as metabolic radiosensitizers in hypoxic tumors. The compounds make cancer cells more sensitive to radiation therapy without the concomitant toxicity issues that can occur as a side-effect of papaverine.
Radiation therapy is a common treatment for cancerous tumors. However, environmental conditions in the tumor can influence sensitivity to radiation therapy, and some cells are resistant to treatment. For example, hypoxic cells (those with low levels of oxygen) in tumors such as lung, glioblastoma,…
  • College: College of Medicine (COM)
  • Inventors: Denko, Nicholas; Benej, Martin; Mitton-Fry, Mark; Papandreou, Ioanna; Vibhute, Sandip
  • Licensing Officer: Davis, Stewart

Technologies Advancing the Field of Tissue Stiffness Measurement (Elastography)
TS-014919 — An array of technologies advancing device design, analytic techniques and scope of application of magnetic resonance elastography (MRE)
Magnetic resonance elastography (MRE) combines MRI imaging with sound waves, creating a visual map showing and quantitating the stiffness of body tissue. MRE's initial application has been to the liver, where chronic diseases such as Non-Alcoholic Fatty Liver Disease (estimated background prev…
  • College: College of Medicine (COM)
  • Inventors: Kolipaka, Arunark; Arnold, John; Lee, Francis; White, Richard
  • Licensing Officer: Norris, Francis "Frank"

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