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Revolutionizing Cancer Immunotherapy with Novel Chimeric B-cell Epitope Peptide Vaccines
TS-065697 — Chimeric B-cell epitope peptide vaccines targeting human PD-L1 and/or CTLA-4 to induce immune response against the PD-1/PD-L1 signaling pathway.
The emergence of immune checkpoint inhibitors revolutionized cancer immunotherapy. Monoclonal antibodies targeting PD-1, PD-L1 and CTLA-4 have shown impressive clinical outcomes. The Need Despite their effectiveness, current monoclonal antibody treatments have limitations such as low response ra…
  • College: College of Medicine (COM)
  • Inventors: Kaumaya, Pravin
  • Licensing Officer: Willson, Christopher

E-Cadherin-based Oncolytic Viral Cancer for Glioblastoma
TS-062682 — Glioblastoma (GBM) is the most common malignant brain tumor accounting for 47.7% of all brain cancers. Unfortunately, treatments are limited, and survival is poor, with approximately 40% living the first-year post-diagnosis and 17% in the second year. The Need Oncolytic viruses (OVs) are a prom…
  • College: College of Medicine (COM)
  • Inventors: Yu, Jianhua; Caligiuri, Michael; Xu, Bo
  • Licensing Officer: Taysavang, Panya

An innovative platform to enhance the efficacy of oncolytic virotherapy for cancer treatment through E-cadherin
TS-062679 — Glioblastoma (GBM) is the most common malignant brain tumor accounting for 47.7% of all brain cancers. Unfortunately, treatments are limited, and survival is poor, with approximately 40% living the first-year post-diagnosis and 17% in the second year. The Need Oncolytic viruses (OVs) are a prom…
  • College: College of Medicine (COM)
  • Inventors: Yu, Jianhua; Caligiuri, Michael; Xu, Bo
  • Licensing Officer: Taysavang, Panya

A novel VSV-based vaccine platform for Zika virus
TS-062261 — The Need: Addressing the Zika Virus Outbreak The Zika virus outbreak, which started in South America and quickly became a global public health issue, has led to severe neurological disorders, birth defects, and other health complications in affected populations. Despite efforts to combat the virus,…
  • College: College of Medicine (COM)
  • Inventors: Peeples, Mark; Li, Jianrong
  • Licensing Officer: Bhatti, Hamid

Live vaccine candidate for Chagas disease
TS-044084 — Trypanosoma cruzi is a protozoan parasite that causes Chagas disease, a PRV-eligible disease that is the leading cause of heart failure in Latin America. Due to migration of infected hosts from endemic regions, Chagas disease is also a growing public health concern in the USA and other migrant des…
  • College: College of Medicine (COM)
  • Inventors: McGwire, Bradford
  • Licensing Officer: He, Panqing

Novel Immunomodulators and Vaccine Adjuvants
TS-038032 — A class of compounds possessing potent immunomodulatory activity, to enhance the protection of vaccines against infectious agents.
While vaccines are commonly used today for a variety of diseases and have proven efficacious for disease prevention, some vaccines do not efficiently activate an immune response. About 10% of vaccinations fail to mount adequate antibody levels to routine vaccinations. Also, many viruses rapidly mu…
  • College: College of Medicine (COM)
  • Inventors: Satoskar, Abhay; Ainslie, Kristy; Bachelder, Eric; Fuchs, James; Kinghorn, Alan "Dr. A. Douglas Kinghorn"; Parinandi, Narasimham
  • Licensing Officer: Willson, Christopher

Mutant Hydrogenase Bacteria for Use against Enteric Pathogens
TS-015013 — Hydrogenase enzyme deficient bacterial strains that may be used as vaccines or attenuating agents for enteropathogenic diseases.
Enteric pathogens are responsible for an estimated two million deaths annually and cause millions more cases of diarrheal illness even in developed countries. When an individual contracts an enteric pathogen such as S. typhimurium, the infected individual will continue to shed the pathogen for up …
  • College: College of Medicine (COM)
  • Inventors: Gunn, John
  • Licensing Officer: Taysavang, Panya

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