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Nras Mouse Melanoma Cell Lines
TS-049491 — Dr. Christin Burd's lab at The Ohio State University has developed a set of Nras-mutant mouse melanoma cell lines that can be used for preclinical tumor immunology and cancer biology studies.
Studies show that 15-30% of melanomas are Nras driven and 60% of melanomas are Braf driven. Dr. Christin Burd's lab at The Ohio State University has developed a set of Nras-mutant mouse melanoma cell lines that complement a set of Braf cell lines developed by Marcus Bosenberg at Yale Universit…
  • College: College of Medicine (COM)
  • Inventors: Burd, Christin; Murphy, Brandon
  • Licensing Officer: Davis, Stewart

Monoclonal Antibody for Cereblon
TS-015144 — Highly specific and effective murine cereblon (CRBN) antibody for high quality immunoassays.
Cereblon (CRBN) is a 51 kDa protein encoded by the gene CRBN. This protein is a target of the immunomodulatory drugs thalidomide, lenalidomide, and pomalidomide that show substantial activity in several hematologic cancers, including multiple myeloma, acute myeloid leukemia, and chronic lymphocyti…
  • College: College of Medicine (COM)
  • Inventors: Lucas, David; Byrd, John
  • Licensing Officer: Davis, Stewart

Novel Spin Adduct for Free Radical Elimination
TS-015133 — 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO) as an improved cyclic spin trap, especially in mitigating superoxide radicals.
The linear PBN-type nitrones are limited by their ability to discern different radicals while the cyclic DMPO-type nitrones are limited by the stability of the adducts they form. Enolized DMPO-type spin adducts have been shown to dimerize and produce a six-line electron paramagnetic resonance (EPR…
  • College: College of Medicine (COM)
  • Inventors: Zweier, Jay; Hadad, Christopher; Villamena, Frederick
  • Licensing Officer: Davis, Stewart

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