# of Displayed Technologies: 9 / 9

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Method for diagnosis and prognosis of Alzheimer's disease
TS-050046 — Methods using miRNAs for early Alzheimer’s Disease diagnoses and altered expression of key autophagy related proteins
The Need Alzheimer’s Disease (AD) is the most common cause of age-related dementia leading to severe and irreversible neurodegeneration and cognitive decline. Currently, AD has no cure or effective preventive approaches. Using current diagnostic techniques, AD cannot be clinically diagnosed b…
  • College: College of Medicine (COM)
  • Inventors: Amer, Amal
  • Licensing Officer: Flammang, Ann Marie

miRNA Biomarkers for Diagnosis and Prediction of Radiation Induced Injury
TS-041968 — A minimally invasive procedure to determine radiation toxicity in victims of nuclear events or radiation therapy patients.
The lack of a reliable radiation biodosimeter has been a major barrier to medical decision-making regarding the triage and treatment of persons - civilians, soldiers and first-time responders - who might be at risk for developing acute radiation syndromes (ARS) following nuclear events (e.g. nucle…
  • College: College of Medicine (COM)
  • Inventors: Jacob, Naduparambil "Naduparambil"
  • Licensing Officer: Norris, Francis "Frank"

miRNA Biomarkers for Diagnosis and Prediction of Radiation Induced Injury
TS-041968 — A minimally invasive procedure to determine radiation toxicity in victims of nuclear events or radiation therapy patients.
The lack of a reliable radiation biodosimeter has been a major barrier to medical decision-making regarding the triage and treatment of persons - civilians, soldiers and first-time responders - who might be at risk for developing acute radiation syndromes (ARS) following nuclear events (e.g. nucle…
  • College: College of Medicine (COM)
  • Inventors: Jacob, Naduparambil "Naduparambil"
  • Licensing Officer: Norris, Francis "Frank"

Virtual image generation of immunohistochemical stained tissue sections using an artificial neural network
TS-039781 — Realistic immunohistochemical stained tissue section databases for training, certification, and machine standards.
Immunohistochemistry (IHC) is used to determine antigen distribution in a tissue and is widely used for diagnosis of cancers and other diseases. Diagnostic and research laboratories in the United States use locally devised IHC tissue slide preparation and scanning protocols to check scanner perfor…
  • College: College of Medicine (COM)
  • Inventors: Gurcan, Metin; Lozanski, Gerard; Senaras, Caglar
  • Licensing Officer: Norris, Francis "Frank"

Automated Detection of Tumor Budding in Colorectal Cancer
TS-039267 — A non-invasive and automated tumor budding image analysis system for colorectal cancer. This program can detect tumor buds in traditional H&E stained sections without the need for manual assessment.
Colorectal cancer is the third most commonly diagnosed cancer in the United States. With a survival rate of less than 65%, early detection and treatment are key factors in survival. Tumor budding, associated with higher tumor stage, lymph node metastasis, and decreased disease-free survival, has e…
  • College: College of Medicine (COM)
  • Inventors: Gurcan, Metin; Ahmad Fauzi, Mohammad Faizal; Chen, Wei "Wei"; Frankel, Wendy
  • Licensing Officer: Norris, Francis "Frank"

Methylated Peptides Derived from Tau Protein and Their Antibodies as Diagnostic and Therapeutic Reagents for Alzheimer's Disease
TS-037626 — A diagnostic to provide more swift and reliant detection of Alzheimer's disease by monitoring the chemical modification of tau proteins in bodily fluids.
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is the leading cause of dementia worldwide. While there are some indications of genetic predisposition, the etiology of the disease is primarily unknown, but it does progress with age. Diagnosis of the disease is critical at…
  • College: College of Medicine (COM)
  • Inventors: Kuret, Jeffrey; Funk Johnson, Kristen; Yang, Austin
  • Licensing Officer: Flammang, Ann Marie

Circulating Microvesicles Biomarkers and Molecular Targets in Disease
TS-035400 — Discovery of microvesicles containing microRNA from myeloid cells that can serve as biomarkers and molecular targets
In the last decade, scientific research showed exponential growth in publications on exosomes, cell-derived microvesicles. Many researchers are convinced that these tiny vesicles have unlimited potential in diagnostics and therapeutics, especially in oncology treatments. Microvesicles facilitate c…
  • College: College of Medicine (COM)
  • Inventors: Marsh, Clay; Hunter, Melissa; Ismail, Noura
  • Licensing Officer: Ezzell, Janel

Technologies Advancing the Field of Tissue Stiffness Measurement (Elastography)
TS-014919 — An array of technologies advancing device design, analytic techniques and scope of application of magnetic resonance elastography (MRE)
Magnetic resonance elastography (MRE) combines MRI imaging with sound waves, creating a visual map showing and quantitating the stiffness of body tissue. MRE's initial application has been to the liver, where chronic diseases such as Non-Alcoholic Fatty Liver Disease (estimated background prev…
  • College: College of Medicine (COM)
  • Inventors: Kolipaka, Arunark; Arnold, John; Lee, Francis; White, Richard
  • Licensing Officer: Norris, Francis "Frank"

Mass Spectrometry Thrombotic Thrombocytopenic Purpura (TTP) Diagnostic Assay
TS-014915 — A rapid diagnostic test for Thrombotic Thrombocytopenic Purpura.
Thrombotic Thrombocytopenic Purpura (TTP) is a life-threatening microangiopathic thrombotic disorder that requires immediate diagnosis and emergency plasmapheresis therapy to prevent organ-system failure(s). Untreated TTP has a high mortality rate, but rapid diagnosis and plasma exchange therapy y…
  • College: College of Medicine (COM)
  • Inventors: Cataland, Spero; Bissell, Michael; Jin, Ming; Wu, Haifeng
  • Licensing Officer: Flammang, Ann Marie

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