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Multifunctional RNA Nanoparticles and Methods for Treating Cancer
TS-040289 — Three-way junction nanoparticles for delivery of tamoxifen and other therapeutics directly to tumor cells.
Most breast cancers express estrogen receptor alpha (ER α) and antagonists of ER α drugs, such as tamoxifen, have been widely used for their treatment. Unfortunately, up to half of all ER α -positive tumors have intrinsic or acquired endocrine therapy resistance. Recent studies b…
  • College: College of Pharmacy
  • Inventors: Zhang, Xiaoting; Guo, Peixuan
  • Licensing Officer: Flammang, Ann Marie

Engineered Guide RNA as a Tool for CRISPR/Cpf1 Gene Editing
TS-036754 — This technology aims to optimize the CRISPR-Cpf1 complex by chemically modifying the crRNA nucleotides and engineering crRNA sequences.
CRISPR technology is a new and exciting tool for editing the genomes of live organisms. With CRISPR, researchers have replaced target genes with chosen alternative genes in species ranging from bacteria to live mice. The CRISPR system uses either the Cas9 or Cpf1 protein to bind a given DNA sequen…
  • College: College of Pharmacy
  • Inventors: Dong, Yizhou; Li, Bin
  • Licensing Officer: Flammang, Ann Marie

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