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Electrophiles for Re-activation of Aged Acetylcholine Esterase
TS-044619 — Organophosphorus (OP) poisons including sarin, VX, and novichoks are lethal agents of chemical warfare. Their toxicity is due to their direct inhibition of acetylcholinesterase (AChE), an enzyme that is vital to the nervous system via regulation of the neurotransmitter acetylcholine (ACh). AChE in…
  • College: College of Arts & Sciences
  • Inventors: Hadad, Christopher; Callam, Christopher; Corrigan, Thomas; Dicken, Rachel; Dogan Ekici, Ozlem; Fitzpatrick, Keegan; Franjesevic, Andrew; McElroy, Craig; McKenney, Ryan; Muthukrishnan, Siva; Sanan, Toby; Vyas, Shubham; Yoder, Ryan; Young, Amneh "Amneh"
  • Licensing Officer: Dahlman, Jason "Jay"

Electrophiles for Re-activation of Aged Acetylcholine Esterase
TS-044619 — Organophosphorus (OP) poisons including sarin, VX, and novichoks are lethal agents of chemical warfare. Their toxicity is due to their direct inhibition of acetylcholinesterase (AChE), an enzyme that is vital to the nervous system via regulation of the neurotransmitter acetylcholine (ACh). AChE in…
  • College: College of Arts & Sciences
  • Inventors: Hadad, Christopher; Callam, Christopher; Corrigan, Thomas; Dicken, Rachel; Dogan Ekici, Ozlem; Fitzpatrick, Keegan; Franjesevic, Andrew; McElroy, Craig; McKenney, Ryan; Muthukrishnan, Siva; Sanan, Toby; Vyas, Shubham; Yoder, Ryan; Young, Amneh "Amneh"
  • Licensing Officer: Dahlman, Jason "Jay"

Translational Activators of the Glutamate Transporter EAAT2 to Treat Neurological and Psychiatric Diseases
TS-043938 — Small molecule technology with novel translational activation mechanism.
Glutamate is a major neurotransmitter in the mammalian central nervous system (CNS) and essential for normal brain function including cognition, memory, and learning. However, the extracellular concentration of glutamate must remain below excitotoxic levels (~ 1 μM) to avoid overstimulation of …
  • College: College of Medicine (COM)
  • Inventors: Lin, Chien-Liang
  • Licensing Officer: Dahlman, Jason "Jay"

A Novel Vectored Vaccine Against Human Norovirus
TS-037664 — A live recombinant vesicular stomatitis virus (VSV)-vector vaccine composition for human norovirus.
Human norovirus (HuNoV) is a major causative agent of foodborne gastroenteritis worldwide. It is estimated that over 90% of outbreaks of acute nonbacterial gastroenteritis are caused by noroviruses. Healthcare facilities, including nursing homes and hospitals, are the most commonly reported place …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Li, Jianrong; Ma, Yuanmei
  • Licensing Officer: Dahlman, Jason "Jay"

Discovery of a novel CD34(+) natural killer precursor population in human lymph nodes
TS-037651 — Ohio State University researchers have discovered novel subset of human CD34 (+) hematopoietic precursor cells and generated a method of isolating them.
Natural killer (NK) cells are a type of lymphocyte that plays a role in the immune system. These cells can react against and destroy another cell without prior sensitization to it. The role of NK cells in tumor activity is known, but recent research has also linked them to other immune disease con…
  • College: College of Medicine (COM)
  • Inventors: Caligiuri, Michael; Becknell, Michael; Freud, Aharon
  • Licensing Officer: Dahlman, Jason "Jay"

Novel Small-Molecule Integrin-linked Kinase/Phosphoinositide-dependent Protein Kinase-2 Inhibitors
TS-037647 — A novel set of molecules that inhibit integrin-linked kinase in order to suppress tumor cell growth and metastasis.
The Akt signaling pathway is responsible for apoptosis, cell proliferation, and metabolism. In tumor cells, this pathway is up-regulated and aids in promoting cancer cell survival. Complete activation of Akt pathway requires phosphorylation at two amino-acid residues, which are phosporylated by se…
  • College: College of Pharmacy
  • Inventors: Chen, Ching-Shih; Kulp, Samuel; Lee, Su-Lin
  • Licensing Officer: Dahlman, Jason "Jay"

Combination Agent Approach for Improved Expansion and Mobilization of Hematopoietic Stem Cells
TS-037629 — Combined treatment of plerixafor and Flt3L better mobilize stem cells and do not exacerbate graft-versus-host disease following transplatation.
Hematopoietic stem cell transplantation (HSCT) is used in patients with hematologic malignancies resulting from irradiation and graft-versus-tumor effects. However, patients who undergone HSCT may suffer complications such as graft-versus-host disease (GVHD), infection, and relapse. The most commo…
  • College: College of Medicine (COM)
  • Inventors: Yu, Jianhua; Caligiuri, Michael; Devine, Steven
  • Licensing Officer: Dahlman, Jason "Jay"

Novel Vaccine for Respiratory Syncytial Virus
TS-037299 — Recombinant vesicular stomatitis virus (rVSV) vaccines to fight against respiratory syncytial virus (RSV) infections.
Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory tract illness (ALRI) in infants, children, and the elderly, and often leads to fatal bronchiolitis and pneumonia. About 3.4 million children under the age of five are hospitalized each year due to an acute RSV in…
  • College: College of Veterinary Medicine
  • Inventors: Niewiesk, Stefan; Binjawadagi, Basavaraj; Li, Jianrong; Peeples, Mark
  • Licensing Officer: Dahlman, Jason "Jay"

Aza-peptide Aldehydes and Ketones: A New Class of Inhibitors for Proteases
TS-037264 — Novel aza-peptide reversible protease inhibitors, which permit more drug-like and selective activity than current irreversible aza-peptide containing inhibitors.
Proteases play an important role in cell processes such as apoptosis, immune response, protein turnover, digestion, blood coagulation and wound healing, fertilization, cell differentiation and growth, and cell signaling among other processes. Due to their large involvement in such processes, uncon…
  • College: College of Arts & Sciences
  • Inventors: Dogan Ekici, Ozlem; Corrigan, Thomas; Hadad, Christopher
  • Licensing Officer: Dahlman, Jason "Jay"

Estrogen Receptor Beta Agonist Compounds
TS-015086 — Estrogen Receptor Beta Agonists for the treatment of breast, colon, and prostate cancers as well as inflammatory diseases.
There is a large emphasis on the need for novel and more effective cancer therapeutics, since there were nearly 600,000 cancer deaths in the United States in 2016 alone. One method for therapy of prostate, breast, and colon cancer that has been gaining traction is the targeting of estrogen recepto…
  • College: College of Pharmacy
  • Inventors: Tjarks, Werner; Bartunek, Petr; Sedlak, David
  • Licensing Officer: Dahlman, Jason "Jay"

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