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mCherry Fluorescence-Producing Ehrlichia chaffeensis: Revolutionizing Bacterial Detection
TS-065847 — The Need: In today's world, rapid and accurate detection of bacterial pathogens is crucial for safeguarding public health and animal well-being. With the emergence of diseases transmitted by ticks and the increasing importance of understanding vector-borne infections, there's a pressing need…
  • College: College of Veterinary Medicine
  • Inventors: Rikihisa, Yasuko; Lin, Mingqun "Mingqun"
  • Licensing Officer: Dahlman, Jason "Jay"

Monoclonal Antibodies for Soybean Rust Diagnostic Assay
TS-065454 — The Need: As agriculture faces increasing challenges from plant pathogens, rapid and accurate detection methods are crucial to safeguarding crop yields and ensuring food security. Traditional methods of pathogen detection often suffer from delays in diagnosis, leading to significant crop damage and …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Dorrance, Anne; Luster, Douglas; McMahon, Michael; Miller, Sally
  • Licensing Officer: Dahlman, Jason "Jay"

Drosophila melanogaster muscle stem cell line
TS-064271 — The Need In the rapidly advancing landscape of life sciences, researchers and biotech companies face an escalating demand for reliable and versatile cell lines. The need for a specialized cell line that combines adaptability, reproducibility, and ease of use is paramount in accelerating breakthroug…
  • College: College of Arts & Sciences
  • Inventors: Simcox, Amanda
  • Licensing Officer: Dahlman, Jason "Jay"

A modified intein for temperature sensitive applications
TS-063697 — Controlled Protein Release Over a Broad Range of Temperatures
The Need: In the biotechnology field, the demand for efficient protein purification methods and innovative drug delivery solutions is ever-growing. Researchers and companies require technologies that can streamline the purification process, ensuring high yields and purity, while offering versatile …
  • College: College of Engineering (COE)
  • Inventors: Wood, David; Coolbaugh, Michael; Stimple, Samuel "Sam"; Yuan, Hongyu
  • Licensing Officer: Dahlman, Jason "Jay"

Advanced AAV Gene Therapy Characterization Technique
TS-062608 — Gene therapy is an emerging technology that replaces a faulty gene or adds a new gene to cure disease or improve your body's ability to fight infection. These next-generation treatments hold promise for treating various genetic and chronic conditions, including but not limited to cancer, cystic …
  • College: College of Arts & Sciences
  • Inventors: Wysocki, Vicki; Cleary, Sean; Du, Chen
  • Licensing Officer: Dahlman, Jason "Jay"

Functional "fingerloop" DNA antisense motifs for nucleic acid targeting and detection technologies
TS-062547 — The Need: The field of molecular biology and genetic engineering faces challenges in achieving precise and accurate detection and amplification of target nucleic acid sequences. Traditional hybridization technologies suffer from the issue of mismatched targets, leading to reduced specificity and rel…
  • College: College of Arts & Sciences
  • Inventors: Lease, Richard
  • Licensing Officer: Dahlman, Jason "Jay"

Revolutionizing Cancer Research: Unveiling the Dynamics of K-Ras for Targeted Therapies
TS-062433 — The Need: Understanding the intricate functions of the K-Ras protein is crucial in combating various types of human cancer. However, the lack of detailed atomic-level information has hindered progress in this area, leaving significant gaps in our comprehension of its roles in health and disease. Th…
  • College: Enterprise for Research, Innovation and Knowledge (ERIK)
  • Inventors: Bruschweiler, Rafael; Bruschweiler-Li, Lei "Lei"; Hansen, Alexandar "Alex"; Xiang, Xinyao; Yuan, Chunhua
  • Licensing Officer: Dahlman, Jason "Jay"

Bat Tissue Samples (Desmodus rotundus)
TS-062351 — The Need: In today's fast-paced world, advancements in scientific research and medical breakthroughs are critical to addressing pressing global challenges. The study of bats and their unique biology has become increasingly important due to their potential role as reservoirs for zoonotic diseases…
  • College: College of Arts & Sciences
  • Inventors: Carter, Gerald
  • Licensing Officer: Dahlman, Jason "Jay"

Anaplasma Platys Diagnostics
TS-062349 — The Need In the veterinary field, there is a crucial need for accurate and specific diagnostic tests to identify and distinguish between Anaplasma platys (Apl) and other related pathogens like Anaplasma phagocytophilum (Aph). Current diagnostic methods lack specificity, leading to challenges in dif…
  • College: College of Veterinary Medicine
  • Inventors: Rikihisa, Yasuko
  • Licensing Officer: Dahlman, Jason "Jay"

Method and device for determining virus titer by surface enhanced Raman scattering
TS-062346 — The ability to rapidly identify and determine virus titer is of utmost importance in numerous biomedical applications, ranging from gene editing to pharmaceutical and vaccine development. In the context of lentiviruses, which are widely used for cell reprogramming in immunotherapies, knowing the e…
  • College: College of Arts & Sciences
  • Inventors: Schultz, Zachary; Morder, Courtney
  • Licensing Officer: Dahlman, Jason "Jay"

Ion Carpet-Based Surface-Induced Dissociation Device
TS-062342 — The Need In the field of mass spectrometry (MS), the study of proteins and protein complexes in their native form, known as native MS, has become crucial in understanding their structure and function. However, the current collision-induced dissociation (CID) technique used in tandem MS experiments …
  • College: College of Arts & Sciences
  • Inventors: Wysocki, Vicki; Gilbert, Joshua; Stiving, Alyssa
  • Licensing Officer: Dahlman, Jason "Jay"

Generation of T cell-specific CXCR3 Transgenic mouse
TS-062320 — The Need: Addressing Susceptibility to Cutaneous Leishmaniasis Cutaneous leishmaniasis, caused by the intracellular parasite Leishmania major and transmitted by sand flies, poses a significant threat to susceptible populations. This disfiguring disease results in large skin lesions, impacting both …
  • College: College of Arts & Sciences
  • Inventors: Satoskar, Abhay; Oghumu, Steve
  • Licensing Officer: Dahlman, Jason "Jay"

Primers and Probe for the Detection of Maize Chlorotic Mottle Virus (MCMV)
TS-062260 — The Need: Efficient and accurate diagnosis of maize lethal necrosis (MLN)-causing viruses is essential for MLN surveillance programs and testing seed for zero tolerance of Maize chlorotic mottle virus (MCMV) in seed lots. To effectively manage MLN in both farmers' fields and commercial seed fie…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Miller, Sally; Baysal-Gurel, Fulya; Ma, Xing; Redinbaugh, Margaret "Peg"
  • Licensing Officer: Dahlman, Jason "Jay"

Avian Genome Editing Advancements- Improving production efficiency
TS-062249 — The Need: Unlocking Avian Genetic Potential The poultry industry plays a crucial role in meeting the growing demand for protein-rich food worldwide. However, avian genetic research has been limited by the complexity of editing avian genomes efficiently. Conventional methods utilizing primordial ger…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Lee, Kichoon "Kichoon"; Lee, Joonbum
  • Licensing Officer: Dahlman, Jason "Jay"

Understanding Dynamics of the Gut- Germ-free cockroach model animal
TS-062239 — The Need: In today's rapidly evolving world, understanding complex biological processes and their implications has become crucial for various industries, including agriculture, pharmaceuticals, and environmental conservation. Researchers and practitioners seek innovative reseach tools that can …
  • College: College of Arts & Sciences
  • Inventors: Sabree, Zakee; Jahnes, Benjamin "Ben"
  • Licensing Officer: Dahlman, Jason "Jay"

Identification of Bacteria That Promote Plant Growth with Low Fertilizer Inputs.
TS-062225 — The Need: Enhancing Greenhouse Ornamental Crop Production with Plant Growth Promoting Rhizobacteria (PGPR) In the competitive and environmentally-conscious market of greenhouse ornamental crop production, the need for sustainable and efficient cultivation methods has become increasingly paramount. …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Jones, Michelle; Chapin, Laura; Nordstedt, Nathan; South, Kaylee
  • Licensing Officer: Dahlman, Jason "Jay"

Method for controlling multiple heterogenous magnetic bacteria at a solid-liquid interface using uniform magnetic fields
TS-053222 — Manipulatable miniaturized robots have a variety of applications in biomedical sciences, specifically microrobots capable of navigating in vivo blood vessels have the potential to revolutionize non-invasive surgery and targeted drug delivery for cancer and other disease treatment. Drug discovery c…
  • College: College of Arts & Sciences
  • Inventors: Wijesinghe, Hiran
  • Licensing Officer: Dahlman, Jason "Jay"

Quadruplex-based non-enzymatic DNA signal amplification
TS-042905 — A quadruplex-based non-enzymatic DNA signal amplification scheme for point of care diagnostic testing.
Currently, non-enzymatic signal amplification assays, an alternative to PCR, are complicated reactions employing multiple DNA constructs. The most successful non-enzymatic assays rely on stand-displacement reactions within DNA duplexes that result in background activity. Because of this background…
  • College: College of Arts & Sciences
  • Inventors: Kankia, Besik
  • Licensing Officer: Dahlman, Jason "Jay"

CXCR3-GFP knock-in mouse
TS-038221 — A knock-in murine model that expresses high levels of GFP in CXCR3 positive cells.
Chemokines are typically small, secreted molecules that participate in leukocyte trafficking, recruitment, and activation. They also play roles in normal and pathological processes including allergic responses, infectious and autoimmune disease, angiogenesis, inflammation, and tumor growth and met…
  • College: College of Arts & Sciences
  • Inventors: Satoskar, Abhay; Oghumu, Steve
  • Licensing Officer: Dahlman, Jason "Jay"

Canine Lymphoma Cell Line
TS-015190 — A novel canine lymphoma cell line developed from the malignant pleural effusion of a dog with peripheral T-cell lymphoma.
Lymphoma is the most common life-threatening cancer of dogs, accounting for up to 24% of all malignancies and over 80% of all hematopoietic cancers. Spontaneously occurring lymphoma in the dog has many of the same histopathological, molecular, and clinical features as non-Hodgkin’s lymphoma …
  • College: College of Veterinary Medicine
  • Inventors: Kisseberth, William
  • Licensing Officer: Dahlman, Jason "Jay"

Real-Time Quadruplex Priming Amplification (QPA) for Nucleic Acid Amplification and Quantification
TS-014824 — An enhanced nucleic acid amplification system that is more efficient and cost-effective than conventional polymerase chain reaction methods.
Identification of a particular nucleic acid is desirable in the use of diagnostic and forensic applications. However, often the target nucleic acid sequence may only be a small portion of the DNA or RNA in question so that it might be difficult to detect the presence of the target sequence using p…
  • College: College of Arts & Sciences
  • Inventors: Kankia, Besik
  • Licensing Officer: Dahlman, Jason "Jay"

High-repetition rate, liquid thin-film laser target inserter
TS-014771 — A variable thickness liquid film target is generated at repetition rates in excess of 10 Hz for laser interaction applications
Intense laser-matter experiments utilize high-powered lasers that generate extreme temperatures and pressures to impact small, thin targets that are usually solid metallic foils millimeters in length and nanometers to microns in thickness. The number of particles accelerated and amount of radiatio…
  • College: College of Arts & Sciences
  • Inventors: Poole, Patrick; Andereck, Claude; Schumacher, Douglass
  • Licensing Officer: Dahlman, Jason "Jay"

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