# of Displayed Technologies: 10 / 30


Categories

Targeting β-catenin signaling in combination with EGFR TKI enhances progression free survival and overall survival of EGFR mutant NSCLC
TS-042666 — The discovery of a novel treatment for EGFR TKI drug resistance in NSCLC.
Non-small cell lung cancer (NSCLC), which accounts for 85% of all lung cancers, is one of the leading causes of cancer-related death. Substantial progress has been made in the management of NSCLC as several driver mutations have been identified in cell communication pathways involved in lung tumor…
  • College: College of Medicine (COM)
  • Inventors: Arasada, Rajeswara Rao; Carbone, David
  • Licensing Officer: Davis, Stewart

Papaverine Derivatives that are Effective Hypoxic Tumor Radiosensitizers
TS-041504 — Dr. Nicholas Denko and colleagues at The Ohio State University have developed papaverine derivatives that can be used as metabolic radiosensitizers in hypoxic tumors. The compounds make cancer cells more sensitive to radiation therapy without the concomitant toxicity issues that can occur as a side-effect of papaverine.
Radiation therapy is a common treatment for cancerous tumors. However, environmental conditions in the tumor can influence sensitivity to radiation therapy, and some cells are resistant to treatment. For example, hypoxic cells (those with low levels of oxygen) in tumors such as lung, glioblastoma,…
  • College: College of Medicine (COM)
  • Inventors: Denko, Nicholas; Benej, Martin; Mitton-Fry, Mark; Papandreou, Ioanna; Vibhute, Sandip
  • Licensing Officer: Davis, Stewart

The STEMcoding Learning Management System
TS-040123 — The STEMcoding Learning Management System is a tool for incorporating computer programming activities into introductory STEM courses.
As technology becomes more advanced over time, the need for people with programming knowledge increases, especially in fields where technology can be used to improve efficiency. Despite the fact that STEM courses have not traditionally used programming activities to teach concepts, there are vast …
  • College: College of Arts & Sciences
  • Inventors: Orban, Christopher; Britt, Christopher "Christopher"; Porter, Christopher
  • Licensing Officer: Davis, Stewart

A novel synthetic immunomodulator and an adjuvant for vaccines
TS-038032 — A natural plant product possessing potent immunomodulatory activity, which primes T cell immune responses, and could be used for vaccine development.
While vaccines are commonly used today for a variety of diseases and have proven efficacious for disease prevention, some vaccines do not efficiently activate an immune response. Adjuvants can be included in a given vaccine to potentiate immune activation and improve the quality of the vaccine. Th…
  • College: College of Medicine (COM)
  • Inventors: Satoskar, Abhay; Ainslie, Kristy; Bachelder, Eric; Fuchs, James; Kinghorn, Douglas; Parinandi, Narasimham
  • Licensing Officer: Davis, Stewart

BuckeyeVR 3D Plotter
TS-037914 — A flexible framework for students and instructors to plot mathematical functions, curves, and vector fields in stereoscopic 3D using a smartphone.
Math and science courses often require students to plot and understand graphs. While many students can comprehend two-dimensional (2D) graphs, analysis of a three-dimensional (3D) plot in a 2D rendering can prove difficult. With the development of virtual and augmented reality (VR and AR, respecti…
  • College: College of Arts & Sciences
  • Inventors: Orban, Christopher; Brown, Jonathan; Fowler, James; Madar, Savva; Porter, Christopher; Smith, Joseph; Snapp, Bart
  • Licensing Officer: Davis, Stewart

A novel STK1-targeted small molecule as an "antibiotic resistance breaker"
TS-037880 — Inh2-B1 serves as a therapeutically important “antibiotic-resistance-breaker,” which enhances the bactericidal activity of Ceftriaxone/Cefotaxime against highly pathogenic MDRSA infection.
Highly pathogenic and multidrug-resistant Staphylococcus species encompasses methicillin-resistant strains of S. aureus (MDRSA) and S. epidermidis (MDRSE) that have developed resistance to multiple traditional antibiotics, including the 5th generation cephalosporin (Ceftaroline). Because of the re…
  • College: College of Medicine (COM)
  • Inventors: Pancholi, Vijay
  • Licensing Officer: Davis, Stewart

Family HealthLink: A Health Risk Assessment Tool
TS-037825 — An online interactive tool that helps a patients and physicians assess a likelihood of cancer or heart disease, based on family history.
Physician documentation of family history in the EPIC® EMR for breast and ovarian cancer has been a common practice for many years, but documentation and assessment for other cancer types (and extended family history) have remained sparse and incomplete (Sweet, Sturm et al. 2015). In addition …
  • College: College of Medicine (COM)
  • Inventors: Sweet, Kevin; Newman, David "David"; Sturm, Amy; Westman, Judith "Judy"
  • Licensing Officer: Davis, Stewart

Pyrrolopyrimidine Derivatives as Mps1/TTK Kinase Inhibitors for Cancer Therapy
TS-037724 — Small molecules for targeted treatment of triple negative breast cancer and other aggressive phenotypes.
Breast cancer is a heterogeneous group of tumors which can be subdivided based on histopathological features, genetic alterations, and gene-expression profiles. Approximately 50-60% of all breast cancer patients and two-thirds of postmenopausal breast cancer patients have estrogen receptor positiv…
  • College: College of Pharmacy
  • Inventors: Brueggemeier, Robert; Fisk, Harold; Li, Chenglong; Li, Pui-Kai "Tom"; Sugimoto, Yasuro
  • Licensing Officer: Davis, Stewart

Cbl-b Inhibition as a Therapeutic Approach to Disseminated Candidiasis
TS-037695 — Disseminated C. albicans infection in patients who have a weakened immune system is life threatening and causes 40% of bloodstream infections (candidemia) in hospitals. Despite the availability of several anti­fungal drugs, invasive candidiasis still has a high mortality rate ranging from 19-4…
  • College: College of Medicine (COM)
  • Inventors: Zhang, Jian; Rappleye, Chad
  • Licensing Officer: Davis, Stewart

A Closed Loop System for Responsive Precise Intraparenchymal Delivery of Adenosine for the Treatment of Epilepsy
TS-037644 — Medical device for controlling seizures.
Adenosinergic neuromodulation plays a crucial role in control of seizure activity and is described as the brain's endogenous anticonvulsant. Intraparenchymal infusion of adenosine into epileptogenic regions of the brain has been shown to control seizures (anti-ictogenic) and prevent progressiv…
  • College: College of Medicine (COM)
  • Inventors: Oluigbo, Chima
  • Licensing Officer: Davis, Stewart

Show More Technologies

Loading icon