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Apoprotein manufacturing and methods for protein purification
TS-046794 — Methods of purifying proteins that can be used in various applications such as drug delivery and detoxification of byproducts of hemolysis.
Novel protein and apoprotein purification strategies are valuable tools with a wide variety of medical and research applications. While there are existing techniques for protein and apoprotein purification, some of these have flaws such as the use of harsh denaturants, highly flammable solvents, l…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Belcher, Donald; Palmer, Andre
  • Licensing Officer: Davis, Stewart

Therapeutic uses of the apohemoglobin-haptoglobin complex
TS-046454 — Original, synthetic complexes used to detoxify hemoglobin, heme, and free iron in patients suffering from hemolysis. The use of these complexes would allow effective treatment of various states of hemolysis and would mitigate the numerous side effects associated with the condition. Complexes could also be used as a drug carrier for targeting CD163+ macrophages and monocytes.
Hemolysis is a burgeoning health condition that results from various pathophysioloigical conditions. It is characterized by the rupture of red blood cells, which release toxic, cell-free hemoglobin into the bloodstream. The cell-free hemoglobin further break down into heme and apoglobin, which cau…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Cabrales, Pedro; Palmer, Andre
  • Licensing Officer: Davis, Stewart

Louie: An Augmented Reality Sensory Trigger Wayfinding System for People with Autism
TS-043077 — An Augmented Reality Sensory Trigger Wayfinding System for People with Autism
Millions of people on the Autism spectrum face challenges getting from place to place due to sensory sensitivities to sounds, sights, smells, tastes, physical feelings, and crowds. Due to these triggers, people with Autism have a strong need to know where they are going and what will be there so t…
  • College: College of Engineering (COE)
  • Inventors: Ezell, Jonathan; Kaufman, Robert; Kaufman, Michael
  • Licensing Officer: Davis, Stewart

Targeting β-catenin signaling in combination with EGFR TKI enhances progression free survival and overall survival of EGFR mutant NSCLC
TS-042666 — The discovery of a novel treatment for EGFR TKI drug resistance in NSCLC.
Non-small cell lung cancer (NSCLC), which accounts for 85% of all lung cancers, is one of the leading causes of cancer-related death. Substantial progress has been made in the management of NSCLC as several driver mutations have been identified in cell communication pathways involved in lung tumor…
  • College: College of Medicine (COM)
  • Inventors: Arasada, Rajeswara Rao; Carbone, David
  • Licensing Officer: Davis, Stewart

Papaverine Derivatives that are Effective Hypoxic Tumor Radiosensitizers
TS-041504 — Dr. Nicholas Denko and colleagues at The Ohio State University have developed papaverine derivatives that can be used as metabolic radiosensitizers in hypoxic tumors. The compounds make cancer cells more sensitive to radiation therapy without the concomitant toxicity issues that can occur as a side-effect of papaverine.
Radiation therapy is a common treatment for cancerous tumors. However, environmental conditions in the tumor can influence sensitivity to radiation therapy, and some cells are resistant to treatment. For example, hypoxic cells (those with low levels of oxygen) in tumors such as lung, glioblastoma,…
  • College: College of Medicine (COM)
  • Inventors: Denko, Nicholas; Benej, Martin; Mitton-Fry, Mark; Papandreou, Ioanna; Vibhute, Sandip
  • Licensing Officer: Davis, Stewart

Separation of Small Hydrophobic Ligands from Proteins via Tangential Flow Filtration
TS-040370 — Novel strategy to separate hydrophobic ligands from proteins through the use of Tangential Flow Filtration in which efficiency, safety, and scalability are improved. Enhanced production of proteins in this native state holds promise both for improved research and biomedical applications.
Successfully isolating proteins in their non-liganded state (i.e. apoprotein form) allows for an in-depth study of proteins from a research perspective. From an application standpoint apoproteins hold tremendous promise as both potential therapeutics and as drug delivery vehicles given their natur…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Belcher, Donald; Palmer, Andre
  • Licensing Officer: Davis, Stewart

Identifying the level of lupus patients’ comprehension of their medication regimens and disease outcomes
TS-040132 — A questionnaire used to understand a patient’s comprehension of their personalized medication plan and the disease fluctuation of systemic lupus erythematous (SLE).
Systemic lupus erythematous (SLE) is an autoimmune disease in which the body’s immune system attacks healthy tissue in its own body. The disease has a prevalance of twenty to 150 cases per 100,000 individuals, and is more common in females than in men. This chronic disease has no cure, and s…
  • College: College of Medicine (COM)
  • Inventors: Meara, Alexa; Ardoin, Stacy; Peters, Ellen
  • Licensing Officer: Davis, Stewart

The STEMcoding Learning Management System
TS-040123 — The STEMcoding Learning Management System is a tool for incorporating computer programming activities into introductory STEM courses.
As technology becomes more advanced over time, the need for people with programming knowledge increases, especially in fields where technology can be used to improve efficiency. Despite the fact that STEM courses have not traditionally used programming activities to teach concepts, there are vast …
  • College: College of Arts & Sciences
  • Inventors: Orban, Christopher; Britt, Christopher "Christopher"; Porter, Christopher
  • Licensing Officer: Davis, Stewart

A novel synthetic immunomodulator and an adjuvant for vaccines
TS-038032 — A natural plant product possessing potent immunomodulatory activity, which primes T cell immune responses, and could be used for vaccine development.
While vaccines are commonly used today for a variety of diseases and have proven efficacious for disease prevention, some vaccines do not efficiently activate an immune response. Adjuvants can be included in a given vaccine to potentiate immune activation and improve the quality of the vaccine. Th…
  • College: College of Medicine (COM)
  • Inventors: Satoskar, Abhay; Ainslie, Kristy; Bachelder, Eric; Fuchs, James; Kinghorn, Douglas; Parinandi, Narasimham
  • Licensing Officer: Davis, Stewart

BuckeyeVR 3D Plotter
TS-037914 — A flexible framework for students and instructors to plot mathematical functions, curves, and vector fields in stereoscopic 3D using a smartphone.
Math and science courses often require students to plot and understand graphs. While many students can comprehend two-dimensional (2D) graphs, analysis of a three-dimensional (3D) plot in a 2D rendering can prove difficult. With the development of virtual and augmented reality (VR and AR, respecti…
  • College: College of Arts & Sciences
  • Inventors: Orban, Christopher; Brown, Jonathan; Fowler, James; Madar, Savva; Porter, Christopher; Smith, Joseph; Snapp, Bart
  • Licensing Officer: Davis, Stewart

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