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Electrophiles for Re-activation of Aged Acetylcholine Esterase
TS-044619 — Organophosphorus (OP) poisons including sarin, VX, and novichoks are lethal agents of chemical warfare. Their toxicity is due to their direct inhibition of acetylcholinesterase (AChE), an enzyme that is vital to the nervous system via regulation of the neurotransmitter acetylcholine (ACh). AChE in…
  • College: College of Arts & Sciences
  • Inventors: Hadad, Christopher; Callam, Christopher; Corrigan, Thomas; Dicken, Rachel; Dogan Ekici, Ozlem; Fitzpatrick, Keegan; Franjesevic, Andrew; McElroy, Craig; McKenney, Ryan; Muthukrishnan, Siva; Sanan, Toby; Vyas, Shubham; Yoder, Ryan; Young, Amneh "Amneh"
  • Licensing Officer: Ezzell, Janel

Aza-peptide Aldehydes and Ketones: A New Class of Inhibitors for Proteases
TS-037264 — Novel aza-peptide reversible protease inhibitors, which permit more drug-like and selective activity than current irreversible aza-peptide containing inhibitors.
Proteases play an important role in cell processes such as apoptosis, immune response, protein turnover, digestion, blood coagulation and wound healing, fertilization, cell differentiation and growth, and cell signaling among other processes. Due to their large involvement in such processes, uncon…
  • College: College of Arts & Sciences
  • Inventors: Dogan Ekici, Ozlem; Corrigan, Thomas; Hadad, Christopher
  • Licensing Officer: Ezzell, Janel

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