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Electrophiles for Re-activation of Aged Acetylcholine Esterase
TS-044619 — Organophosphorus (OP) poisons including sarin, VX, and novichoks are lethal agents of chemical warfare. Their toxicity is due to their direct inhibition of acetylcholinesterase (AChE), an enzyme that is vital to the nervous system via regulation of the neurotransmitter acetylcholine (ACh). AChE in…
  • College: College of Arts & Sciences
  • Inventors: Hadad, Christopher; Callam, Christopher; Corrigan, Thomas; Dicken, Rachel; Dogan Ekici, Ozlem; Fitzpatrick, Keegan; Franjesevic, Andrew; McElroy, Craig; McKenney, Ryan; Muthukrishnan, Siva; Sanan, Toby; Vyas, Shubham; Yoder, Ryan; Young, Amneh "Amneh"
  • Licensing Officer: Ezzell, Janel

Antennae and sensor impregnated mat to monitor biological variables and indicators of health
TS-041742 — A functional fabric mat with the capability to monitor and track anthropometric and biofeedback data accompanied by an application to integrate information and securely share with healthcare providers.
Currently, anthropometric and biological measurements in the healthcare setting are made with individual devices that require both specialized equipment and time on the part of the patient and healthcare provider. Additionally, patient data is often static in nature as the opportunity for measurem…
  • College: College of Nursing
  • Inventors: Militello, Lisa; Kiourti, Asimina
  • Licensing Officer: Ezzell, Janel

Multi-Functional Cancer Drug Delivery Nanodevice for Precision Medicine
TS-041485 — Using the scaffolded DNA origami molecular self-assembly process, a manufactured DNA nanostructure can be created that circumvents MDR1/MRP-1 protein efflux pump-mediated multi-drug resistance in cancer cells to deliver clinically significant concentrations of chemotherapeutics.
The majority of human cancers remain incurable, in many cases this is due to innate or developed multi-drug resistance (MDR). Current therapeutics used in treatment are inadequate in light of such resistance, and more robust approaches must be found to circumvent these responses and deliver therap…
  • College: College of Engineering (COE)
  • Inventors: Castro, Carlos; Byrd, John; Halley, Patrick; Lucas, Christopher
  • Licensing Officer: Ezzell, Janel

Synthetic apratoxins and novel analogs for anticancer and therapeutic applications
TS-039269 — Synthetic natural apratoxins and non-natural apratoxin analogs with improved pharmacokinetic profiles for cancer treatments and drug development applications.
Apratoxins are potent cytotoxic biosynthetic products that are naturally produced by specific marine microorganisms. When isolated from organisms, the compounds display very potent anticancer activities. In addition, they have been implicated in immunosuppressive activity. However, in their natura…
  • College: College of Arts & Sciences
  • Inventors: Forsyth, Craig; Jackel, Matthew; Li, Xiao
  • Licensing Officer: Ezzell, Janel

Digital Analysis and Lesion Segmentation Software for Tele-Dermatology
TS-038429 — An automated image analysis system for the recognition and quantification of skin disease.
Acne and rosacea are skin diseases that affect around 85% of individuals. There is no gold standard for evaluation of these skin diseases, and their treatment efficacy is generally determined according to a poorly validated counting process by the physician and patient. This process is prone to po…
  • College: College of Medicine (COM)
  • Inventors: Kaffenberger, Benjamin; Gurcan, Metin
  • Licensing Officer: Ezzell, Janel

RNA Sequencing Assay to Detect Gene Fusion Mutations that Occur in Multiple Cancer Types
TS-038065 — OSU­-SpARKFUSE is an RNA sequencing assay that detects known and novel gene fusion mutations in multiple cancer types.
Chromosomal rearrangements, leading to the juxtaposition of two unrelated genes and thus creating a chimeric mRNA transcript and protein ("gene fusions"), are important drivers of abnormal cell growth in cancers. Although gene fusions have a well-established role in hematologic malignanc…
  • College: College of Medicine (COM)
  • Inventors: Roychowdhury, Sameek
  • Licensing Officer: Ezzell, Janel

Autophagosome-Lysosome Fusion Inhibition Enhances Flavopiridol Efficacy in Cancer
TS-037639 — A novel method to increase the effectiveness and practicality of the cancer treatment drug Flavopiridol.
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia and the current therapies are not curative. High-risk genetic modifications are associated with poor response to traditional therapies. Flavopiridol, a broad-spectrum cyclin-dependent kinase inhibitor, activates significant clini…
  • College: College of Medicine (COM)
  • Inventors: Byrd, John; Grever, Michael; Johnson, Amy; Lucas, David; Mahoney, Emilia
  • Licensing Officer: Ezzell, Janel

Nanopump Separation Device and Method
TS-037584 — A device for separating macromolecules in a solution of macromolecules having different molecular sizes
Many clinical and research applications involve separation of specific biological molecules, such as nucleic acids and proteins, for further analysis and characterization. A complex biological system can only be understood after each component has been separately analyzed, and proteins must be pur…
  • College: College of Engineering (COE)
  • Inventors: Hansford, Derek; Walczak, Robbie
  • Licensing Officer: Ezzell, Janel

The Link between EGFL7 and AML
TS-037353 — Expansion of human hematopoietic stem and progenitor (HSPC) cells using Epidermal Growth Factor­-Like protein 7 (EGFL7).
Despite recent progress in understanding acute myeloid leukemia (AML) biology and the use of intensive treatments, the long-term overall survival is only 30-40% in younger (<60 years) and <10% in older adult AML patients. This highlights the urgent need for novel therapeutic approaches for a…
  • College: College of Medicine (COM)
  • Inventors: Dorrance, Adrienne; Garzon, Ramiro; Shen, Changxian
  • Licensing Officer: Ezzell, Janel

Gene delivery to adipose tissue using novel recombinant adeno-associated viral vectors
TS-037310 — An engineered recombinant adeno-associated virus capable of targeting fat tissue previously inaccessible to this viral vector for the purposes of genetic manipulation.
Recombinant adeno-associated viruses (rAAVs) are effective tools for delivering gene therapy treatment and for manipulation of acquired diseases. However, there is no effective method to target adipose tissue and transduction efficiency is low in naturally occurring AAV serotypes. In addition, cur…
  • College: College of Medicine (COM)
  • Inventors: Cao, Lei; Huang, Wei
  • Licensing Officer: Ezzell, Janel

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