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Novel Natural Product Derivatives Targeting Chronic Diseases
TS-050220 — Novel natural products and derivatives thereof that exhibit potent in vitro and in vivo activity
The Need Metabolic disorders such as type 2 diabetes are a major health concern that have impacted hundreds of millions of adults worldwide. Current pharmaceutical therapies for type 2 diabetes have been associated with adverse reactions including weight gain and increased risk of infection, liver …
  • College: College of Pharmacy
  • Inventors: Carcache de Blanco, Esperanza; Anaya Eugenio, Gerardo David; Eggers, Nicole
  • Licensing Officer: Flammang, Ann Marie

The Buckeye Quit Stick: A novel support device to address the hand-to-oral cigarette habit of patients who are attempting to quit smoking
TS-050189 — A novel support device to address the hand-to-oral cigarette habits of patients who are attempting to quit smoking.
The Need Tobacco addiction is a common problem in cancer patients and more than half of newly diagnosed lung cancer patients are active smokers. Smoking can affect a patient’s surgical safety, quality of life, and cancer recovery and survival outcomes. While treatment products can successfull…
  • College: College of Nursing
  • Inventors: Both, Deborah; Eastep, Christine
  • Licensing Officer: Flammang, Ann Marie

Method for diagnosis and prognosis of Alzheimer's disease
TS-050046 — Methods using miRNAs for early Alzheimer’s Disease diagnoses and altered expression of key autophagy related proteins
The Need Alzheimer’s Disease (AD) is the most common cause of age-related dementia leading to severe and irreversible neurodegeneration and cognitive decline. Currently, AD has no cure or effective preventive approaches. Using current diagnostic techniques, AD cannot be clinically diagnosed b…
  • College: College of Medicine (COM)
  • Inventors: Amer, Amal
  • Licensing Officer: Flammang, Ann Marie

Analogues of the Epipolythiodioxopiperazine Alkaloids
TS-047118 — Analogues of verticillin which have more useful drug-like properties than the verticillin parent compounds alone, including increased solubility, absorption, and stability, all while maintaining similar anticancer potency to the original compounds.
Verticillins, which are epipolythiodioxopiperazine (ETP) alkaloids, have shown promising anticancer qualities; these fungal metabolites have exhibited high potency against a variety of tumor cell types, with IC50 values typically in the 10-500 nanomolar range. However, these compounds suffer from …
  • College: College of Pharmacy
  • Inventors: Fuchs, James; Huntsman, Andrew
  • Licensing Officer: Flammang, Ann Marie

Novel spectroscopic sensor for screening nutritional and quality traits of field crops
TS-046751 — A novel sensor for the screening of field crops, one example being the amino acids in soybeans. This allows the quality and nutritional value of the soybeans to be evaluated quickly and simply. This technology would benefit not only farmers and producers of soybeans and soy products, but also consumers by manufactures to know the quality of the ingredients received to be monitored.
Nutritional components of soybeans, specifically their amino acid profiles, are important when evaluating the quality of soybeans. Currently, the only methods for evaluating soybean nutritional traits are to either send samples to a lab for testing, which is costly and takes several weeks to compl…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rodriguez-Saona, Luis; Ball, Christopher; Krishna, Sanjay; Ronningen, Theodore; Sia, Amanda
  • Licensing Officer: Flammang, Ann Marie

Production of a stable blend of casein and plant proteins with improved physical and flavor characteristics
TS-046583 — This process creates a stable, desirable blend of casein and plant proteins that includes improvements on the physical and flavor characteristics of the blend. It has applications in areas such as dairy production, fitness supplements, and foods. With improved stability, flavor, and physical characteristics, it represents a needed improvement over current methods of casein and plant protein blending.
Food proteins have countless biological purposes, and the demand for protein has steadily increased in recent years. Meanwhile, however, dairy consumption has been decreasing. Dairy producers must therefore innovate in order to attract customers. Using currently available methods, the combination …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Jimenez-Flores, Rafael; Mayta Apaza, Alba; Ortega-Anaya, Joana; Tieu, Stiphany
  • Licensing Officer: Flammang, Ann Marie

Adoptive Transfer of Engineered Macrophages
TS-045881 — The Need Cell therapies have received recent approvals for immunomodulatory indications. Immuno-activating chimeric antigen receptor (CAR)–T cells have been developed for cancers, whereas immunosuppressive mesenchymal stromal cells (MSCs) have been approved for inflammatory bowel disease and …
  • College: College of Pharmacy
  • Inventors: Dong, Yizhou; Hou, Xucheng; Zhang, Xinfu
  • Licensing Officer: Flammang, Ann Marie

Adoptive Transfer of Engineered Macrophages
TS-045881 — The Need Cell therapies have received recent approvals for immunomodulatory indications. Immuno-activating chimeric antigen receptor (CAR)–T cells have been developed for cancers, whereas immunosuppressive mesenchymal stromal cells (MSCs) have been approved for inflammatory bowel disease and …
  • College: College of Pharmacy
  • Inventors: Dong, Yizhou; Hou, Xucheng; Zhang, Xinfu
  • Licensing Officer: Flammang, Ann Marie

mRNA sequence engineering and uses thereof
TS-045448 — Maximized mRNA lifespan and translation for mRNA-based therapy applications.
Many diseases emerge from irregularities that occur during protein synthesis. While limited therapies exist to deliver mature proteins to compensate for these errors, protein therapy by direct protein delivery has limited efficiency. This is due to difficulty in controlling the volume of delivered…
  • College: College of Pharmacy
  • Inventors: Dong, Yizhou; Zeng, Chunxi
  • Licensing Officer: Flammang, Ann Marie

Improving immunotherapy with mRNA delivery
TS-045426 — The central mission of cancer immunotherapy treatments is to aid the immune system in detecting and degrading cancer cells. For twenty years, the use of monoclonal antibodies (mAbs) as anti-tumor drugs has been successful in managing cancer disease and increasing patient lifespan. These treatments…
  • College: College of Pharmacy
  • Inventors: Dong, Yizhou; Li, Wenqing; Zhang, Chengxiang
  • Licensing Officer: Flammang, Ann Marie

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