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miRNA detection system and method
TS-046585 — A system for detecting the presence of a target single stranded nucleic acid, such as miRNA, in a fluid sample. The system can be used to target RNA for a variety of different purposes that include diagnostic biomarkers and biomedical research. The expanding uses of RNA make this technology viable for a large number of fields and applications with the potential for the diagnosis of a variety of diseases using bodily fluid samples such as urine, saliva, milk, and blood.
RNA is emerging as a potential component in a plethora of fields. As evidence has been compiled, it is now recognized that RNA plays a major role in human genetics, and is projected to be a major milestone in future drug development. Unfortunately, routine methods of miRNAs, including qPCR and mic…
  • College: College of Pharmacy
  • Inventors: Guo, Peixuan; Vieweger, Mario; Yin, Hongran
  • Licensing Officer: Flammang, Ann Marie

Novel Phosphors for Solid-State Lighting Applications
TS-046581 — Novel halide perovskite phosphor that, when paired with blue LED light, creates warm white light without the need for high temperature ceramics in its production and does not contain rare-earth elements. It has several applications including solid-state lighting and white LEDs. The phosphors produce light with a natural appearance and extended excitation spectra.
Phosphors are used in a variety of products and for a variety of reasons. Halide perovskite phosphors, a specific type of phosphor, can be combined with light emitting diodes (LED) to create phosphor converted LEDs (pc-LED). The current technology has several shortcomings; deficiency in red and cy…
  • College: College of Arts & Sciences
  • Inventors: Woodward, Patrick; Gray, Matthew; Majher, Jackson
  • Licensing Officer: Flammang, Ann Marie

Isolated Milk Phospholipids and MFGM
TS-045170 — Process for isolating and producing a high milk phospholipid ingredient from a by-product of the dairy industry, also commonly known as Milk Fat Globule Membrane (MFGM).
Milk phospholipds are in demand in the food industry because they promote good gut health and cognitive development in adults and infants. Currently, phospholipids can be extracted from a high fat fraction of milk sweet whey. Unlike the sweet whey from natural cheese manufacturing, the acid whey f…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Jimenez-Flores, Rafael; Ortega-Anaya, Joana
  • Licensing Officer: Flammang, Ann Marie

Improved Dressing Design for Insertion Sheaths with Side Ports
TS-044969 — Dressing designed and tailored exclusively for insertion sheaths with side ports, used frequently for pulmonary artery catheters (PACs or Swan-Ganz catheters) among other intravascular devices in the hospital.
The Need Central-line associated blood stream infections (CLABSIs) are a life-threatening and extremely costly problem in hospitals around the world. When patients in the hospital have indwelling catheters such as pulmonary artery catheters, they are at an increased risk of developing such infectio…
  • College: OSU Wexner Medical Center
  • Inventors: Warren, Samantha; Thomas, Jordan
  • Licensing Officer: Flammang, Ann Marie

Biomimetic vitreous substitute with ocular drug delivery
TS-044490 — Methods and compositions for an antioxidant releasing hydrogel vitreous substitute
The vitreous humor is a fragile, transparent tissue between the lens and the retina of the eye that maintains the shape of the eye, acts as a shock absorber, and enables nutrient diffusion to ocular tissues. The vitreous also plays a key role in oxygen homeostasis. Over time, the vitreous degrades…
  • College: College of Engineering (COE)
  • Inventors: Swindle-Reilly, Katelyn; Reilly, Matthew; Tram, Nguyen "Archie"
  • Licensing Officer: Flammang, Ann Marie

Nanoparticle Composition for Nucleic Acid Delivery
TS-044109 — Lipid nanoparticles (LNs) usable for the delivery of therapeutic compositions, including, but not limited to nucleic acids (NAs).
Nucleic Acid (NA) based therapies are used to inhibit gene expression. Lipid nanoparticles (LNs) are capable of carrying these therapies into cells. However, this delivery requires overcoming several physiological barriers. For instance, one barrier is the acidic endosome conditions within the cel…
  • College: College of Pharmacy
  • Inventors: Lee, Robert
  • Licensing Officer: Flammang, Ann Marie

System for Immobilizing the Skull during Transcranial Focused Ultrasound Ablation
TS-043964 — A non-invasive method for immobilizing the skull of a patient undergoing surgery. The device consists of pads for contacting screws from a standard stereotactic frame and a headband that result in immobilization without damage to the skin or skull.
Both stereotactic neurosurgery and transcranial focused ultrasound surgery systems have historically required a stereotactic frame to precisely position and completely immobilize a patient's head to ensure the correct location for the operation. This frame consists of multiple pins that must b…
  • College: College of Medicine (COM)
  • Inventors: Sammartino, Francesco; Beam, Dylan; Krishna, Vibhor
  • Licensing Officer: Flammang, Ann Marie

A Bi-layered Capsule for Sustainable Delivery of Protein Therapeutics
TS-042858 — A biodegradable drug delivery system for the treatment of disease, especially ophthalmic diseases including age-related macular degeneration (AMD). The device will be injected and can control drug release for at least 6 months following the initial injection.
Retinal diseases can be extremely difficult to monitor once procedures have been initiated. AMD is the fourth most common causes of blindness and requires monthly injections to manage the effects of the disease and prevent permanent blindness. However, receiving recurrent injections can potentiall…
  • College: College of Engineering (COE)
  • Inventors: Jiang, Pengfei; Coutinho da Silva, Marco; Lannutti, John; Ohr, Matthew; Swindle-Reilly, Katelyn
  • Licensing Officer: Flammang, Ann Marie

Engineered Cells for Treatment of Animal Metabolic Disorders
TS-041976 — The implantation of engineered thermogenic cells for treating metabolic disease and obesity in animals.
Obesity remains one of the main underlying causes for many malignancies in domestic animals such as cats, dogs, and horses. From a veterinary perspective, obesity dramatically increases the risk of cancer, one of the leading causes of death in domesticated animals. Other diseases correlated with o…
  • College: College of Education & Human Ecology
  • Inventors: Ziouzenkova, Ouliana
  • Licensing Officer: Flammang, Ann Marie

Junctional Tourniquet for Groin and Axillary Regions
TS-041808 — A tourniquet with a ratcheting lock to keep pressure on wounds in the groin and axillary regions. Hemostasis can be achieved while the patient is still in the field.
Patients with blood loss in the field need to be treated immediately to prevent ongoing blood loss, shock, and death; bleeding from extremity and junctional wounds is the leading cause of potentially preventable death from penetrating injuries. Direct manual pressure is effective for the initial c…
  • College: OSU Wexner Medical Center
  • Inventors: McElroy, James; Graham, Nadi; Nocera, Tanya
  • Licensing Officer: Flammang, Ann Marie

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