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Development of novel furano-parthenolides for human leukemia treatment
TS-038998 — Parthenolide analogues derived from plants could be effective in treating leukemia or supplementing other treatments.
The American Cancer Society estimates that in 2017 there will be about 1,688,780 new cancer cases diagnosed and 600,920 cancer deaths in the United States. Chemotherapy has improved, but further development is needed to improve the efficacy of this treatment, and cancers can develop multidrug resi…
  • College: College of Pharmacy
  • Inventors: Ren, Yulin
  • Licensing Officer: Flammang, Ann Marie

Thermogenic Biologicals for Obesity Treatment
TS-037747 — Identification and use of novel adipokines for reduction of visceral fat using thermogenesis.
The Need Obesity as a result of an increase in intra-abdominal (or visceral) fat is an independent risk factor for major diseases such as type 2 diabetes and cardiovascular diseases. Risk is increased with higher levels of intra-abdominal fat due to increases in insulin resistance and chronic infla…
  • College: College of Education & Human Ecology
  • Inventors: Ziouzenkova, Ouliana
  • Licensing Officer: Flammang, Ann Marie

Antitumor Arylnaphthalene Lignan Glycosides
TS-037721 — A group of potential antitumor arylnapthalene lignan glycosides, which may be developed as novel cancer chemotherapeutic agents.
Nearly 1 in 6 deaths worldwide are from cancer. Although significant advancements have been made towards treatment and control of cancer progression, there is still a need for improvement and enhancement of available treatments. For the last 50 years, natural therapies, such as plant-derived produ…
  • College: College of Pharmacy
  • Inventors: Kinghorn, Alan "Dr. A. Douglas Kinghorn"; Chai, Hee-Byung; Fuchs, James; Ren, Yulin; Soejarto, Djaja; Swanson, Steven; Yalowich, Jack
  • Licensing Officer: Flammang, Ann Marie

Lipid Nanoparticles for Therapeutic Delivery of Anti-miRs and miRs
TS-037707 — An efficient delivery vehicle for therapeutic oligonucleotides with high efficiency.
The Need MiRNA or miRs are small non-protein coding RNA which are capable of regulating mRNAs in multiple biological pathways, including those involved in cancer development and wound healing. Antagomirs, also known as anti-miRs, inhibit miR activity and could be used to develop therapeutics for in…
  • College: College of Pharmacy
  • Inventors: Lee, Robert
  • Licensing Officer: Flammang, Ann Marie

Novel Use of Fostamatinib as a Therapeutic for Liver Cancer, both as First-Line Therapy and Following Acquired Resistance to Sorafenib
TS-032418 — A combination-therapy that has the potential to overcome and/or prevent the commonly observed acquisition of sorafenib resistance, which is associated with treatment failure in patients with hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) kills nearly all patients within a year of diagnosis, and results in between 250,000 and one million deaths globally per year. In the US, incidences of HCC have nearly tripled in the past 30 years and currently remain one of the fastest growing causes of cancer-relat…
  • College: College of Medicine (COM)
  • Inventors: Motiwala, Tasneem; Regan, Kelly; Reyes, Ryan
  • Licensing Officer: Flammang, Ann Marie

Paenibacterin: A Broad Spectrum Antimicrobial
TS-014990 — Paenibacterin is a new broad-spectrum antimicrobial agent produced by Paenibacillus thiaminolyticus OSY-SE
Antibiotic resistance occurs when bacteria mutate or acquire antibiotic resistant genes from another bacterium. Once this change occurs, the bacteria prevent the antibiotic from controlling or killing a bacterial growth (APUA). This results in the growth and proliferation of bacteria with a strong…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Yousef, Ahmed; Guo, Yaoqi; Huang, En; Yuan, Chunhua; Zhang, Liwen "Liwen"
  • Licensing Officer: Flammang, Ann Marie

Self-Assembly of Camptothecin-Peptide Nanostructures
TS-014812 — An improved delivery mechanism has been developed for camptothecin derivatives which will increase chemotherapeutic efficacy.
Many cancer therapeutics exhibit extremely toxic side effects or have limited efficacy due to low bio-availability. Existing drug delivery technologies can add excessive mass to the therapeutic, grossly expanding the dosage necessary for response. Camptothecin (CPT) is a naturally occurring compou…
  • College: College of Arts & Sciences
  • Inventors: Parquette, Jonathan; Grinstaff, Mark; Kaplan, Jonah; Kim, Se Hye
  • Licensing Officer: Flammang, Ann Marie

Cellular Treatment of Metabolic Disorders
TS-014787 — The implantation of engineered thermogenic cells for treating metabolic disease
Obesity is one of the leading preventable causes of death worldwide, and is progressively becoming more prevalent on a global scale. The condition dramatically increases the risk of many adverse physical and mental conditions including type 2 diabetes, cancers, and cardiovascular disease. Obesity …
  • College: College of Education & Human Ecology
  • Inventors: Ziouzenkova, Ouliana
  • Licensing Officer: Flammang, Ann Marie
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