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Development of novel furano-parthenolides for human leukemia treatment
TS-038998 — Parthenolide analogues derived from plants could be effective in treating leukemia or supplementing other treatments.
The American Cancer Society estimates that in 2017 there will be about 1,688,780 new cancer cases diagnosed and 600,920 cancer deaths in the United States. Chemotherapy has improved, but further development is needed to improve the efficacy of this treatment, and cancers can develop multidrug resi…
  • College: College of Pharmacy
  • Inventors: Ren, Yulin
  • Licensing Officer: Flammang, Ann Marie

A Method of Creating FKBP-Small Molecule Composite Surfaces as Inhibitors of Protein-Protein Interactions
TS-037677 — A mechanism by which the inhibiting effects of drugs and other molecules on protein-protein interactions can be measured.
Protein-protein interactions (PPIs) occur when two or more proteins bind together, and they represent a large group of drug targets. However, PPIs are difficult to disrupt because they usually involve large, two-dimensional target surfaces. Conventional small molecule drugs can bind with high affi…
  • College: College of Medicine (COM)
  • Inventors: Briesewitz, Roger; Pei, Dehua; Wu, Xianghong
  • Licensing Officer: Flammang, Ann Marie
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