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Composition and method of lipid nanoparticles carrying oligonucleotides
TS-043629 — Novel lipid nanoparticles used for carrying antisense oligonucleotides with improved targeting for cancer treatment
Lung cancer is the leading cause of cancer related deaths in the US with approximately 150,000 deaths in 2017. Currently, mildly ineffective chemotherapeutics ripe with adverse side effects are the standard treatment. Antisense oligonucleotides (ASOs) are able to selectively modulate expression of…
  • College: College of Pharmacy
  • Inventors: Lee, Robert; Cheng, Xinwei "Evan"
  • Licensing Officer: Flammang, Ann Marie

Engineered Cells for Treatment of Animal Metabolic Disorders
TS-041976 — The implantation of engineered thermogenic cells for treating metabolic disease and obesity in animals.
Obesity remains one of the main underlying causes for many malignancies in domestic animals such as cats, dogs, and horses. From a veterinary perspective, obesity dramatically increases the risk of cancer, one of the leading causes of death in domesticated animals. Other diseases correlated with o…
  • College: College of Education & Human Ecology
  • Inventors: Ziouzenkova, Ouliana
  • Licensing Officer: Flammang, Ann Marie

Junctional Tourniquet for Groin and Axillary Regions
TS-041808 — A tourniquet with a ratcheting lock to keep pressure on wounds in the groin and axillary regions. Hemostasis can be achieved while the patient is still in the field.
Patients with blood loss in the field need to be treated immediately to prevent ongoing blood loss, shock, and death; bleeding from extremity and junctional wounds is the leading cause of potentially preventable death from penetrating injuries. Direct manual pressure is effective for the initial c…
  • College: OSU Wexner Medical Center
  • Inventors: McElroy, James; Graham, Nadi; Nocera, Tanya
  • Licensing Officer: Flammang, Ann Marie

Nonadhesive Medical Tube Attachment Device
TS-041656 — A device that holds nasogastric tubes, oxygen nasal cannulas, and facial dressings without adhesive.
Nasogastric tubes are used to give patients food and medications. Current commercially available tube holders are adhesive devices that attach to the nose. The devices put pressure on the nose and have to be completely removed to check the skin underneath or to adjust the tubes. Oxygen nasal cannu…
  • College: OSU Wexner Medical Center
  • Inventors: Huffman, Jennifer; West, Tabitha
  • Licensing Officer: Flammang, Ann Marie

Mobile Application to Reduce the Risk of Narcotics Abuse Through Patient and Provider Empowerment
TS-041604 — This mobile application for pain management provides simple tools for patients, providers and researchers to use during clinical trials. The app not only tracks the efficacy of each patient's treatment, it can provide additional information to supplement and support the needs of the clinical trial.
The recent opioid epidemic has devastated American cities and kills 91 Americans per day. 80% of these addicts start with prescription pain killers. Preventative strategies to lower opioid use must be developed as most state adopted regulatory measures have failed. The development of such preventa…
  • College: College of Medicine (COM)
  • Inventors: Chandawarkar, Rajiv; Capek, Allison
  • Licensing Officer: Flammang, Ann Marie

RadApp: A mobile application solution for centralized distribution of information to improve workflow, communication, networking, education, and patient safety in the healthcare setting.
TS-041197 — Medical institutions depend on accessing many sources of changing information in various different forms to be successful. Moreover, distributing this information in a concise user-friendly way for each role in the department can be difficult. In particular, this is important for busy, tertiary-le…
  • College: College of Medicine (COM)
  • Inventors: Makary, Mina; Egbert, Nitin
  • Licensing Officer: Flammang, Ann Marie

Method to improve efficiency and specificity of human tumor targeting and elimination by using a combination of split & splice protein toxins and oncolytic viruses
TS-040838 — Novel strategy to improve efficiency and specificity of tumor treatment via combinative use of a split & splice protein toxin and oncolytic virus.
In combating malignancies as complex as cancer, researchers and clinicians have created a diverse set of strategies to reduce tumor burden. Oncolytic viruses (OVs) have emerged as a promising means of treating this disease due to their potential to selectively target and effectively kill cancer ce…
  • College: College of Arts & Sciences
  • Inventors: Kudryashov, Dmitri; Kudryashova, Elena
  • Licensing Officer: Flammang, Ann Marie

Multifunctional RNA Nanoparticles and Methods for Treating Cancer
TS-040289 — Three-way junction nanoparticles for delivery of tamoxifen and other therapeutics directly to tumor cells.
Most breast cancers express estrogen receptor alpha (ER α) and antagonists of ER α drugs, such as tamoxifen, have been widely used for their treatment. Unfortunately, up to half of all ER α -positive tumors have intrinsic or acquired endocrine therapy resistance. Recent studies b…
  • College: College of Pharmacy
  • Inventors: Zhang, Xiaoting; Guo, Peixuan
  • Licensing Officer: Flammang, Ann Marie

Novel compositions of nanoparticles for nucleic acid therapeutic delivery
TS-040254 — Novel lipid-based nanoparticles that utilize a surfactant to improve self-assembly and stability. Finalized particles can be used for delivery of nucleic acids such as oligonucleotides and plasmid DNA.
Lipid-based nanoparticles (LNPs) have been extensively utilized in nucleic acid delivery. However, there are a number of challenges associated with LNP formulation. It is difficult to make sub-100-nm LNPs with a high nucleic acid concentration by traditional self-assembly methods. LNP synthesis ty…
  • College: College of Pharmacy
  • Inventors: Lee, Robert
  • Licensing Officer: Flammang, Ann Marie

Pulse of the OR: Reducing Operating Room Traffic for Patient Safety and Quality Initiatives
TS-039735 — A method of measuring traffic flow in an operating room to reduce contamination and ensure air quality.
Surgical site infections (SSI) can affect all surgical specialties and are an significant cause of long-term morbidity and mortality in the United States. With a rate of 2.8 infections per every 100 operations, these occurrences can lengthen hospital stays, double readmission rates, and can cost b…
  • College: College of Medicine (COM)
  • Inventors: Quatman, Carmen; Chaudhari, Ajit
  • Licensing Officer: Flammang, Ann Marie

RNA Nanotubes for Single Molecule Sensing and DNA/RNA/Protein Sequencing
TS-039514 — Stable, predictably ordered RNA nanopores for disease diagnosis and biopolymer sequencing.
New rapid and accurate sequencing methods, and disease detection methods are always in high demand. Newer advances in these areas include membrane-anchored structures and synthetics, which allow molecule idenfication and biopolymer sequencing by measuring conductance changes associated with passag…
  • College: College of Pharmacy
  • Inventors: Guo, Peixuan; Li, Hui; Wang, Shaoying
  • Licensing Officer: Flammang, Ann Marie

Automated analytical bioreactor for producing rare secondary metabolites
TS-039273 — A bioreactor that facilitates rapid and automatic (or semiautomatic) monitoring and measuring of rare biological and metabolic events.
A typical fermentor or bioreactor is designed to run batch processes and product information is gathered only at the end of the runs. In such a system, many intermediate metabolites or reaction products are not detected or monitored. Some of these intermediates could be valuable compounds produced…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Yousef, Ahmed; Kasler, David
  • Licensing Officer: Flammang, Ann Marie

Productivity model for Advanced Practice Providers
TS-038991 — A new, well-rounded system of measuring APP productivity
Physician assistants (PAs) and nurse practitioners (NPs) are referred to as advanced practice providers (APPs). They are certified health care professionals who provide care and treatment to patients in collaboration with physicians. Although they are an integral part of many clinics and hospitals…
  • College: OSU Wexner Medical Center
  • Inventors: Rosselet, Robin; Cackler, Scott
  • Licensing Officer: Flammang, Ann Marie

Treatment of Multiple Sclerosis with small molecule IL-6/STAT3 inhibitors
TS-038701 — Small-molecule prodrugs that target IL-6/STAT3 signaling pathway.
Multiple Sclerosis (MS), an unpredictable and disabling autoimmune disease affecting the central nervous system, is the leading cause of non-traumatic neurological disability in young adults. There have been important advances in MS therapy, such as drugs that slow the progression of the disease a…
  • College: College of Medicine (COM)
  • Inventors: Yang, Yuhong; Li, Chenglong; Racke, Michael
  • Licensing Officer: Flammang, Ann Marie

Sustained Release Microparticles for the Treatment of Ocular Diseases
TS-038312 — A novel, intravitreal microparticle injection capable of controlled-release of protein therapies (including anti-VEGF) for tunable periods of 6-12 months after injection for the treatment of age-related macular degeneration.
Age-related macular degeneration (AMD) is the leading cause of blindness in individuals 65 and older and is the third leading cause of blindness worldwide. Wet AMD is characterized by abnormal growth of leaky blood vessels leading to damage to the macula of the retina resulting in vision loss and …
  • College: College of Engineering (COE)
  • Inventors: Jiang, Pengfei; Ohr, Matthew; Reilly, Katelyn
  • Licensing Officer: Flammang, Ann Marie

Nonthermal inactivation of microorganisms using combination of shear and electric fields
TS-037864 — A method to inactivate microorganisms in a fluid without degrading certain properties, by using both mechanical shearing and electric fields.
The US FDA requires all manufactures to subject juice products to a 5-log reduction in the number of the most resistant pathogens. Currently, the most widely used method to inactivate pathogenic bacteria from foods and biological fluids involves the application of heat. However, the food industry …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Sastry, Sudhir; Heskitt, Brian; Mok, Jin Hong; Pyatkovskyy, Taras; Yousef, Ahmed
  • Licensing Officer: Flammang, Ann Marie

Immobilization of Biomolecules (Rubisco) by Self-Assembled Nanostructures
TS-037787 — Nanostructures that enhance the stability of biocatalysts that permit them to be utilized in scalable CO2 conversion processes
Carbon dioxide (CO2) and methane (CH4) are the two most abundant greenhouse gasses, trapping thermal radiation close to the earth's atmosphere and contributing to climate change. These two gasses contributed up to 92% of all the greenhouse gas emissions in 2015 (epa.gov). From an industrial pe…
  • College: College of Arts & Sciences
  • Inventors: Parquette, Jonathan; Satagopan, Sriram; Sun, Yuan; Tabita, Fred
  • Licensing Officer: Flammang, Ann Marie

Use of Gene Product to Treat Nerve Injury and Sarcopenia
TS-037778 — A novel method using the overexpression of survival motor neuron protein to improve motor unity synaptic repair and restore/protect muscle size and function due to sarcopenia
Sarcopenia, the age-related wasting and loss of strength, is an important neuromuscular problem of aging. It affects up to 50% of individuals by the 8th decade, and can lead to impaired mobility, loss of independence, and increased risk of mortality. The neuromuscular system is comprised of groups…
  • College: College of Medicine (COM)
  • Inventors: Burghes, Arthur; Arnold, William; Kaspar, Brian; McGovern, Vicki
  • Licensing Officer: Flammang, Ann Marie

Thermogenic Compositions and Methods
TS-037747 — Biologicals for treatment of obesity related disease, including glucose intolerance and neurological disorders.
Worldwide obesity has tripled over the last 40 years and the incidence of overweight or obese populations is rising in low, middle, and high income countries. An increase in adipose tissue results in higher risk for cardiovascular disease and type 2 diabetes, which increase risk for Alzheimer&rsqu…
  • College: College of Education & Human Ecology
  • Inventors: Ziouzenkova, Ouliana; Parquette, Jonathan
  • Licensing Officer: Flammang, Ann Marie

Antisense Oligonucleotide Development for Treatment of Spinal Muscular Atrophy
TS-037741 — The SMN2 gene contains sequences that regulate the level of inclusion of SMN exon7 in SMN mRNA, and some of these act in a negative manner. Antisense oligonucleotides to block the negative regulating protein binding to these sites can increase inclusion of SMN exon 7 and thus, the amount of SMN being produced.
Spinal muscular atrophy (SMA) is a genetic disorder that affects the control of muscle movement. It is caused by a loss of motor neurons in the spinal cord and brainstem, leading to weakness and atrophy in the muscles used for walking, crawling, sitting up, and head movement. In severe instances, …
  • College: College of Medicine (COM)
  • Inventors: Burghes, Arthur; McGovern, Vicki; Prior, Thomas
  • Licensing Officer: Flammang, Ann Marie

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