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Self-assembled 3D RNA Cage Nanoparticles with Precise Shape and Size for Applications in Medical Sciences, Materials Sciences, Engineering and Nanotechnology
TS-039545 — Self-assembling, highly stable RNA cages amenable to custom functionalization and cargo delivery
One of the primary challenges in therapeutic development is cheap, efficient, and safe drug delivery to specific target tissues. To better target specific tissues, RNA nanotechnology has been progressively applied to generate predefined architectures via self-assembly of modular building blocks. N…
  • College: College of Pharmacy
  • Inventors: Guo, Peixuan; Jasinski, Daniel; Khisamutdinov, Emil; Li, Hui
  • Licensing Officer: Flammang, Ann Marie

RNA Nanotubes for Single Molecule Sensing and DNA/RNA/Protein Sequencing
TS-039514 — Stable, predictably ordered RNA nanopores for disease diagnosis and biopolymer sequencing.
New rapid and accurate sequencing methods, and disease detection methods are always in high demand. Newer advances in these areas include membrane-anchored structures and synthetics, which allow molecule idenfication and biopolymer sequencing by measuring conductance changes associated with passag…
  • College: College of Pharmacy
  • Inventors: Guo, Peixuan; Li, Hui; Wang, Shaoying
  • Licensing Officer: Flammang, Ann Marie

Development of novel furano-parthenolides for human leukemia treatment
TS-038998 — Parthenolide analogues derived from plants could be effective in treating leukemia or supplementing other treatments.
The American Cancer Society estimates that in 2017 there will be about 1,688,780 new cancer cases diagnosed and 600,920 cancer deaths in the United States. Chemotherapy has improved, but further development is needed to improve the efficacy of this treatment, and cancers can develop multidrug resi…
  • College: College of Pharmacy
  • Inventors: Ren, Yulin
  • Licensing Officer: Flammang, Ann Marie

Productivity model for Advanced Practice Providers
TS-038991 — A new, well-rounded system of measuring APP productivity
Physician assistants (PAs) and nurse practitioners (NPs) are referred to as advanced practice providers (APPs). They are certified health care professionals that provide care and treatment to patients under a doctor's supervision. Although they are an integral part of many clinics and hospital…
  • College: OSU Wexner Medical Center
  • Inventors: Rosselet, Robin; Brom, Heather; Butz, Jenna; Cackler, Scott; Chen, Ting; Kent, Kelly; Kipp, Kris; Suwignjo, Ronny
  • Licensing Officer: Flammang, Ann Marie

A prototype device for applying beneficial mites to a greenhouse crop
TS-038983 — A method of evenly distributing beneficial mites throughout a greenhouse using a novel device.
Beneficial insects and mites feed on plant pests to improve overall plant health in greenhouses. Also called "biological controls," these mites are a valuable tool in pest management. Current distribution methods typically blow the mites over the crops, which result in uneven application…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Morse, Justin
  • Licensing Officer: Flammang, Ann Marie

Dietary Carotenoid Assessment Tool (DCAT).
TS-038892 — A screening tool for rapid estimation of dietary carotenoid intake
The Need Diet is a major variable that contributes to human health and disease risk. Decades of scientific research suggest that dietary patterns rich in a variety of fruit and vegetables can reduce the risk of cancer through numerous mechanisms, however accurate dietary assessment remains challeng…
  • College: College of Medicine (COM)
  • Inventors: Clinton, Steven; Grainger, Elizabeth; Schmitz, Ashley; Simpson, Christina "Christi"; Thomas-Ahner, Jennifer
  • Licensing Officer: Flammang, Ann Marie

Identification of a novel exercise-induced compound in breast milk that improves metabolic health of offspring.
TS-038700 — A novel exercise-induced compound in breast milk that improves metabolic health of offspring.
Type 2 diabetes is a complex disease that arises from a combination of environmental and genetic factors. Recent projections suggest that the prevalence of type 2 diabetes will increase to 25% of the U.S. population by 2050. While the incidence of the disease is rising, there is strong epidemiolog…
  • College: College of Medicine (COM)
  • Inventors: Stanford, Kristin; Bode, Lars
  • Licensing Officer: Flammang, Ann Marie

Blue & green colorants derived from naturally sourced delphinidin based anthocyanins
TS-038387 — A healthier, natural alternative to artificial blue and green food product colorants.
Color is a key attribute affecting the overall quality and flavor perception of foods and is critical to the product’s overall acceptance. Due to health concerns (such as allergies and possible carcinogenesis), consumer demand for natural products, and regulatory restrictions, the use of art…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Sigurdson, Gregory; Giusti, M. Monica "Monica"
  • Licensing Officer: Flammang, Ann Marie

Immobilization of Biomolecules (Rubisco) by Self-Assembled Nanostructures
TS-037787 — Nanostructures that enhance the stability of biocatalysts that permit them to be utilized in scalable CO2 conversion processes
Carbon dioxide (CO2) and methane (CH4) are the two most abundant greenhouse gasses, trapping thermal radiation close to the earth's atmosphere and contributing to climate change. These two gasses contributed up to 92% of all the greenhouse gas emissions in 2015 (epa.gov). From an industrial pe…
  • College: College of Arts & Sciences
  • Inventors: Parquette, Jonathan; Satagopan, Sriram; Sun, Yuan; Tabita, Fred
  • Licensing Officer: Flammang, Ann Marie

Thermogenic Biologicals for Obesity Treatment
TS-037747 — Identification and use of novel adipokines for reduction of visceral fat using thermogenesis.
The Need Obesity as a result of an increase in intra-abdominal (or visceral) fat is an independent risk factor for major diseases such as type 2 diabetes and cardiovascular diseases. Risk is increased with higher levels of intra-abdominal fat due to increases in insulin resistance and chronic infla…
  • College: College of Education & Human Ecology
  • Inventors: Ziouzenkova, Ouliana
  • Licensing Officer: Flammang, Ann Marie

Thermogenic Biologicals Treatment of Obesity and Improvement of Insulin Resistance
TS-037746 — Innovative thermogenic biologicals, methods of delivery, and combinational therapy for the treatment of abdominal obesity
Obesity as a result of an increase in intra-abdominal (or visceral) fat is an independent risk factor for major diseases such as type 2 diabetes and cardiovascular diseases due to increases in insulin resistance and chronic inflammation. Accumulation of intra-abdominal fat, even in non-­obese …
  • College: College of Education & Human Ecology
  • Inventors: Ziouzenkova, Ouliana; Parquette, Jonathan
  • Licensing Officer: Flammang, Ann Marie

Antitumor Arylnaphthalene Lignan Glycosides
TS-037721 — A group of potential antitumor arylnapthalene lignan glycosides, which may be developed as novel cancer chemotherapeutic agents.
Nearly 1 in 6 deaths worldwide are from cancer. Although significant advancements have been made towards treatment and control of cancer progression, there is still a need for improvement and enhancement of available treatments. For the last 50 years, natural therapies, such as plant-derived produ…
  • College: College of Pharmacy
  • Inventors: Kinghorn, Alan "Dr. A. Douglas Kinghorn"; Chai, Hee-Byung; Fuchs, James; Ren, Yulin; Soejarto, Djaja; Swanson, Steven; Yalowich, Jack
  • Licensing Officer: Flammang, Ann Marie

Lipid Nanoparticles for Therapeutic Delivery of Anti-miRs and miRs
TS-037707 — An efficient delivery vehicle for therapeutic oligonucleotides with high efficiency.
The Need MiRNA or miRs are small non-protein coding RNA which are capable of regulating mRNAs in multiple biological pathways, including those involved in cancer development and wound healing. Antagomirs, also known as anti-miRs, inhibit miR activity and could be used to develop therapeutics for in…
  • College: College of Pharmacy
  • Inventors: Lee, Robert
  • Licensing Officer: Flammang, Ann Marie

Use of Pyranoanthocyanins as a Stable Natural Colorant
TS-036818 — A stable natural colorant derived from fruit and vegetable pigments, with enhanced resistance to bleaching for food applications.
Anthocyanins are pigments in fruits and vegetables that have application as a natural colorant in foods. Their use in juices and beverages, currently the largest market for synthetic dyes in the food industry, is limited due to the fortification of Vitamin C which results in rapid color loss, know…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Farr, Jacob; Giusti, M. Monica "Monica"
  • Licensing Officer: Flammang, Ann Marie

Method for isolation of anthocyanin-mixtures from plant materials.
TS-036614 — A mixed-mode method for the isolation of anthocyanin-mixtures from plant materials.
Many biological studies currently rely on the extraction and fractionation of high purity pigments known as anthocyanins from fruits and vegetables, due to their ability to provide color and potential for increased health benefits. As a result of these benefits, anthocyanins have many applications…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Giusti, M. Monica "Monica"; Simmons, Steven
  • Licensing Officer: Flammang, Ann Marie

Automating the quantification of color space parameters from Visible Spectrum Absorbance
TS-036603 — Verbal communication of color is challenging, therefore mathematically-standardized color spaces are used. ColorBySpectra is software that in one click can convert large sets of absorbance data obtained from a simple spectrophotometer into color spaces: Hunter Lab, CIEL*c*h* and CIEL*a*b*. It reduces time for data collection, and sample volume and equipment needs. The software is useable on multiple platforms and would be useful in food science or other industries interested in precise color information.
There are several commonly used color spaces that quantify perceived color which include Hunter Lab, CIELab, and CIELch. To obtain these values, samples are usually presented to a colorimeter one sample at a time. Obtaining color data can be time consuming for many samples, and special equipment d…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Farr, Jacob; Giusti, M. Monica "Monica"
  • Licensing Officer: Flammang, Ann Marie

Black Goji Anthocyanins for Natural Food Colorant
TS-034593 — Extracted anthocyanins from Black Goji fruits (Lycium ruthenicum Murr) that can be used in the food industry as a potential source of natural color in a wide pH range.
Americans spend about 90 percent of their food budget on processed foods, almost all of which contain a plethora of additives. One of the most frequently used food additives is artificial coloring, and in the past synthetic food colorants were most popular. Increasingly however, public demand has …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Giusti, M. Monica "Monica"; Tang, Peipei
  • Licensing Officer: Flammang, Ann Marie

Simple Suppers: An Educational Cooking and Nutrition Curriculum for Limited-Resource Families
TS-015226 — An extensive collection of inexpensive, well-balanced meals with an accompanying series of lessons packed with fun activities to advance nutritional knowledge and family engagement.
Food insecurity within a household is directly associated with a family’s lack of available resources. Low-income families can often find it difficult to provide enough food, which can cause a reduction in food consumption, disruptive eating patterns, or other unhealthy eating habits. When f…
  • College: College of Education & Human Ecology
  • Inventors: Gunther, Carolyn; Kennel, Julie; Rogers, Catherine "Katy"
  • Licensing Officer: Flammang, Ann Marie

Food-Safe, Naturally Produced Antimicrobials
TS-015129 — A new strain of Paenibacillus polymyxa, producing a stable extra-cellular metabolite, paenibacillin, that has strong antimicrobial activity against Gram-positive bacteria
The emergence of bacterial antibiotic resistance has mobilized the search for new potent antimicrobial agents. Although much of the resistance was observed in hospital environments and related nosocomial infections, there is increasing evidence that resistant food-borne pathogens evolved due to an…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Yousef, Ahmed; He, Zengguo; Kisla, Duygu
  • Licensing Officer: Flammang, Ann Marie

Pressure Resistant pH Meter
TS-015125 — A novel device for measurement of pH over a wide range of pressures and in electrically noisy environments
A pH Meter is an electrical device that is used to measure the concentration of hydrogen ions in a given solution. This solution is often liquid, but can also be used to measure the pH of semi-solid substances. The resulting data indicates whether the solution is acidic or basic, but this discover…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Sastry, Sudhir; Samaranayake, Chaminda
  • Licensing Officer: Flammang, Ann Marie

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