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Gene delivery to adipose tissue using novel recombinant adeno-associated viral (AAV) vectors
TS-037310 — An engineered recombinant adeno-associated virus capable of targeting visceral fat tissue for the purposes of genetic manipulation.
Recombinant adeno-associated viruses (rAAVs) are effective tools for delivering gene therapy treatment and for manipulation of acquired diseases. However, there is no effective method to target adipose tissue and transduction efficiency is low in naturally occurring AAV serotypes. In addition, cur…
  • College: College of Medicine (COM)
  • Inventors: Cao, Lei; Huang, Wei
  • Licensing Officer: Ezzell, Janel

Small-Molecule Cyclin D1 Ablative Agents for Breast Cancer Therapy
TS-015102 — A new class of small-molecule cyclin D1 ablative agents based on troglitazone (TG) that repress intracellular cyclin D1 levels.
Cyclin D1 represents an important downstream effector of diverse proliferative and transforming signaling pathways. In mammary cells, transcriptional activation of Cyclin D1 leads to G1/S phase progression and increased proliferation. Cyclin D1 overexpression has been implicated in oncogene-induce…
  • College: College of Pharmacy
  • Inventors: Chen, Ching-Shih; Huang, Jui-Wen
  • Licensing Officer: Paschall, Christopher

Paenibacterin: A Broad Spectrum Antimicrobial
TS-014990 — Paenibacterin is a new broad-spectrum antimicrobial agent produced by Paenibacillus thiaminolyticus OSY-SE
Antibiotic resistance occurs when bacteria mutate or acquire antibiotic resistant genes from another bacterium. Once this change occurs, the bacteria prevent the antibiotic from controlling or killing a bacterial growth (APUA). This results in the growth and proliferation of bacteria with a strong…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Yousef, Ahmed; Guo, Yaoqi; Huang, En; Yuan, Chunhua; Zhang, Liwen "Liwen"
  • Licensing Officer: Flammang, Ann Marie

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