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Use of Cerium in Neutralizing Iron Impurity in Aluminum Alloys
TS-065429 — Iron is the main and most detrimental impurity in most industrial casting aluminum alloys. Iron content in aluminum alloys is limited, up to 0.1 weight% in some alloys.
Iron is a major impurity element in primary and secondary (scrap) aluminum alloys. It is difficult to remove during melting and casting. Controlling the formation of Al-Fe-based intermetallics via alloying is key to leveraging the mechanical properties of aluminum alloy products. The current struc…
  • College: College of Engineering (COE)
  • Inventors: Luo, Alan; Cinkilic, Emre; Moodispaw, Michael
  • Licensing Officer: Zinn, Ryan

Secure Your Digital Fortress: Revolutionizing Cybersecurity with Next-Gen PUF Technology
TS-065412 — The Need: In contemporary cybersecurity landscapes, the conventional methods of employing Physically Unclonable Functions (PUFs) necessitate maintaining a secure challenge-response database. However, this practice poses significant security risks as access to this database could lead to the comprom…
  • College: College of Arts & Sciences
  • Inventors: Gauthier, Daniel
  • Licensing Officer: Dahlman, Jason "Jay"

Methods to improve the jitter and time walk of integrated constant fraction discriminators
TS-064826 — The Need Accurate measurements of energy and time-of-arrival of photons, particles, or ionizing radiation are crucial for identifying individual particles and enhancing spatial and temporal resolution in various systems. Technologies such as Light Detection and Ranging (LiDAR), positron emission to…
  • College: College of Arts & Sciences
  • Inventors: Kagan, Harris; Abusareya, Mo'men; Khalil, Waleed; Smith, Dale "Shane"
  • Licensing Officer: Dahlman, Jason "Jay"

RNA-TetherTech: Revolutionizing In Vivo Post-Transcriptional Gene Regulation
TS-064267 — In the field of post-transcriptional gene regulation, understanding the functions of RNA-binding proteins is crucial for controlling cellular processes and development in organisms. However, the lack of reliable tools for studying these proteins in vivo, particularly in plant cells, has hindered p…
  • College: College of Arts & Sciences
  • Inventors: Cuerda Gil, Diego
  • Licensing Officer: Dahlman, Jason "Jay"

Three-dimensional cellular automation codes for solidification microstructure and porosity simulation of multi-component alloys
TS-063911 — Porosity formation during the solidification of aluminum-based alloys, induced by hydrogen gas and alloy shrinkage, presents a significant challenge for industries relying on high-performance solidification products such as castings, welds, and additively manufactured components. This issue advers…
  • College: College of Engineering (COE)
  • Inventors: Luo, Alan; Gu, Cheng
  • Licensing Officer: Zinn, Ryan

In situ damage free etching of Ga2O3 using Ga flux for fabricating high aspect ratio 3D structures
TS-062975 — With a high theoretical breakdown field strength, β-Ga2O3 has the potential to be useful in power switching and high frequency power amplifying devices. For any device technology to be competitive, damage free etching techniques are necessary. All current dry etching recipes in β-Ga2O3 h…
  • College: College of Engineering (COE)
  • Inventors: Rajan, Siddharth; Fiedler, Andreas; Kalarickal, Nidhin Kurian
  • Licensing Officer: Zinn, Ryan

Fluorescent probes for intracellular RNA tracking
TS-062554 — The Need: Intracellular RNA fluorescence labeling is a crucial technique for studying cellular processes and understanding gene expression. However, the conventional MS2 labeling method using protein fusion labels can have drawbacks, such as increased mass, potential steric accessibility issues, and…
  • College: College of Arts & Sciences
  • Inventors: Bong, Dennis; Liang, Yufeng
  • Licensing Officer: Willson, Christopher

Purification of apoproteins and general methods for protein purification
TS-062540 — General methods for purifying proteins that can be used in various applications such as targeted drug delivery, bioimaging, and hemolysis treatment.
The Need Novel protein and apoprotein purification strategies are valuable tools with a wide variety of medical and research applications. While there are existing techniques for protein and apoprotein purification, some of these have flaws such as the use of harsh denaturants, highly flammable sol…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Cabrales, Pedro; Palmer, Andre
  • Licensing Officer: Schworer, Adam

Golden-shift Ordered Cartesian sampling (GOC) for Dynamic MRI (Free-breathing Accelerated MRI (Portfolio)
TS-062486 — Magnetic Resonance Imaging (MRI) is a versatile noninvasive imaging tool that is routinely used to evaluate many diseases and conditions. MRI offers exquisite soft tissue contrast and high spatial resolution to enable comprehensive structural and functional assessment of internal organs. Recent innovations in data acquisition and processing can expand the clinical applications of MRI.
The Need A major limitation of MRI is slow data acquisition, which can compromise patient comfort, drive up costs, and increase susceptibility to motion. The clinical adoption of volumetric imaging for musculoskeletal and neuro applications, the growing demand for free-breathing real-time imaging …
  • College: College of Engineering (COE)
  • Inventors: Ahmad, Rizwan; Jin, Ning; Liu, Yingmin; Simonetti, Orlando
  • Licensing Officer: Randhawa, Davinder

Introducing Next-Gen Solid-State Electrolytes: Revolutionizing Energy Storage
TS-062369 — The Need: In the pursuit of large-scale energy storage solutions, potassium batteries with organic liquid electrolytes have emerged as promising candidates. However, the use of liquid electrolytes presents challenges such as dendritic metal plating and oxygen/sulfur crossover from the cathode. To ov…
  • College: College of Arts & Sciences
  • Inventors: Wu, Yiying; Zheng, Jingfeng
  • Licensing Officer: Randhawa, Davinder

Method and Apparatus for Contained-Electrospray for Use in Mass Spectrometry and Droplet Reactions
TS-062326 — The Need: In today's analytical landscape, there is a pressing demand for improved sensitivity in electrospray ionization (ESI) to accurately quantify diverse analytes within complex mixtures. However, this task is often hindered by varying ionization responses among different compounds, includ…
  • College: College of Arts & Sciences
  • Inventors: Badu-Tawiah, Abraham; Kulyk, Dmytro
  • Licensing Officer: Dahlman, Jason "Jay"

Small molecules that reduce the bitter properties of food and beverages
TS-062218 — The Need: Flavor Modulating Compounds for Healthier Food and Beverages In a world where taste preferences drive consumer choices, the demand for nutritious and palatable food and beverages remains at an all-time high. However, many nutrient-rich foods, such as vegetables and whole grains, often possess bitter flavors that can be unappealing to consumers. To make these foods more enjoyable and mask the bitterness, manufacturers frequently resort to excessive amounts of unhealthy additives like fats, sugars, and salts. The result is a trade-off between taste and health, leaving consumers seeking a solution that provides both flavor satisfaction and nutritional benefits. The Technology: Innovative Flavor Modulating Compounds Our technology offers a groundbreaking solution to the challenge of balancing taste and health in food and beverages. Developed as additives for the food industry, our flavor modulating compounds effectively block or modulate bitter flavors, enabling significant reductions in the need for added sugars and salts. By utilizing these compounds, manufacturers can maintain the palatability of their products without compromising on nutritional value. Commercial Applications: Unlocking the Potential The versatility of our flavor modulating compounds opens up numerous commercial applications across various food and beverage categories: Healthy Snacks: Create nutritious and appealing snacks using bitter-rich ingredients, like vegetable chips and whole grain crackers, while minimizing the need for excessive unhealthy additives. Low-Sugar Beverages: Develop refreshing drinks with reduced sugar content, ensuring that consumers enjoy a satisfying taste experience without the guilt of excess sugar consumption. Nutrient-Enhanced Foods: Enhance the flavor profile of nutrient-rich foods, such as salads and soups, to make them more enjoyable, encouraging healthier eating habits. Confectionery: Improve the taste of health-focused sweets and candies, enabling confectionery brands to cater to health-conscious consumers. Ready-to-Eat Meals: Incorporate flavor modulating compounds into pre-packaged meals, enhancing taste while adhering to nutritional guidelines. Benefits/Advantages: Elevating Consumer Experience and Market Appeal Our flavor modulating compounds offer an array of advantages for food and beverage manufacturers, making them a valuable addition to any product development strategy: Healthier Product Profiles: Enable the creation of low-sugar, low-salt products, supporting consumer health and well-being. Uncompromised Taste: Maintain delicious flavor profiles while reducing or eliminating unhealthy additives, satisfying consumer cravings. Market Differentiation: Stand out in a crowded market by offering healthier alternatives without sacrificing taste. Health-Conscious Appeal: Attract health-conscious consumers seeking better-for-you options, expanding your target audience. Regulatory Compliance: Align with evolving nutritional guidelines and regulations, positioning your products for long-term success. In conclusion, our flavor modulating compounds revolutionize the way food and beverages are formulated. By addressing the commercial need for healthier options without compromising on taste, our technology unlocks vast opportunities for manufacturers to create products that appeal to consumers' palates and prioritize their well-being. Join us on this journey towards a future of delightful, nutritious, and flavorful food and drink experiences.
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Peterson, Devin; Gao, Chengyu
  • Licensing Officer: Dahlman, Jason "Jay"

An AI Solution for Mobile Stroke Detection for TeleMedicine, Hospital and Paramedic Use
TS-060782 — Problem Statement: Diagnosis of arterial occlusion and an associated stroke can be lengthy, delaying patient access to treatment. As large vessel occlusions account for 24 to 46% of acute ischemic strokes and may require treatment in a comprehensive stroke center, early diagnosis is key. Solution:…
  • College: College of Engineering (COE)
  • Inventors: Yilmaz, Alper; Gulati, Deepak Kumar
  • Licensing Officer: Hampton, Andrew

3DScope: Detecting 3D Model Clones
TS-057129 — Algorithm for extracting 3D models, indexing them using a value-insensitive normalization algorithm, and comparing the model indexes to detect cloned 3D models.
The unauthorized copying of 3D models robs designers of property, reduces innovation going into the creation of 3D models, creates liability for entities unknowingly using copied models, and indicates a lapse in IP security. With the vast amount of 3D assets in use, it is infeasible for humans to …
  • College: College of Engineering (COE)
  • Inventors: Zuo, Chaoshun; LIN, ZHIQIANG
  • Licensing Officer: Zinn, Ryan

Scalable laser-assisted MOCVD chamber design with laser array input
TS-050244 — A design of scalable laser-assisted MOCVD chamber for III-nitrides and other semiconductors with a laser array input.
III-nitrides represent an important semiconductor material system for both optoelectronic and power electronic device applications. Advantages for III-nitrides include high electron saturation velocity, high critical electric field, high radiation resistance and decent thermal performance. Therefo…
  • College: College of Engineering (COE)
  • Inventors: Zhao, Hongping; Chen, Zhaoying
  • Licensing Officer: Randhawa, Davinder

Capacitive Sensing Method for Integrated Circuit Identification and Authentication
TS-048641 — A method of authenticating an IC die’s origin and uniquely identifying each die with an intrinsic unclonable value through measurement of on-chip capacitance values
Hardware security in Integrated Circuit (IC) designs is of increasing importance in dealing with the insecure, expanding global supply chain of these parts. The ability to trace the origin of a die, combined with the capability to uniquely identify each die provides valuable quantitative measures …
  • College: College of Engineering (COE)
  • Inventors: Khalil, Waleed; Kines, Michael
  • Licensing Officer: Ashouripashaki, Mandana

Nanoparticle Composition for Nucleic Acid Delivery
TS-044109 — Lipid nanoparticles (LNs) usable for the delivery of therapeutic compositions, including, but not limited to nucleic acids (NAs).
Nucleic Acid (NA) based therapies are used to inhibit gene expression. Lipid nanoparticles (LNs) are capable of carrying these therapies into cells. However, this delivery requires overcoming several physiological barriers. For instance, one barrier is the acidic endosome conditions within the cel…
  • College: College of Pharmacy
  • Inventors: Lee, Robert
  • Licensing Officer: He, Panqing

DNA-cage erasable labels for fluorescence-based imaging
TS-043819 — Compositions and methods for analyzing multiple biomarkers without damaging tissue.
Histopathology is a cornerstone of tissue analysis used to diagnose many clinical conditions. Many of these diagnoses are based on identifying the presence of specific biomarkers, which can be indicated by colored labels. Currently, only 1-2 markers can be analyzed per slide, reducing accuracy and…
  • College: College of Engineering (COE)
  • Inventors: Winter, Jessica; Jergens, Elizabeth; Lee, Kil Ho "Kilho"
  • Licensing Officer: Willson, Christopher

Asymmetric Sulfonamide Salts for High-Voltage Li-ion Batteries
TS-041602 — This two-step method synthesizes novel asymmetric sulfonamide based lithium salts that are highly soluble, resulting in a highly-concentrated electrolyte with a large electrochemical window that significantly suppresses aluminum dissolution even in extreme oxidizing conditions.
The market for electric vehicles is steadily increasing; as it continues to grow one problem consistently holding it back is battery capacity. For this market to expand further, methods for storing large amounts of energy safely and affordably must be developed. One approach is to create more capa…
  • College: College of Arts & Sciences
  • Inventors: Wu, Yiying; McCulloch, William
  • Licensing Officer: Randhawa, Davinder

Prognostic Indications of Canine Lymphoid Neoplasia Using Plasma DNA
TS-040419 — A method of identifying a canine lymphoid neoplastic disease with no clinical symptoms using plasma DNA.
Dogs, like humans, are susceptible to development of abnormal growths or cancers. Improved veterinary medical care and diagnostic techniques have enabled a longer lifespan for dogs; however, older populations also have higher incidence rates of canine cancers. This proliferation in incidence of ca…
  • College: College of Veterinary Medicine
  • Inventors: Rush, Laura; Davuluri, Ramana; Kisseberth, William; Singer, Greg; Sun, Hao
  • Licensing Officer: Dahlman, Jason "Jay"

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