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Cold responsive nanoparticles for overcoming cancer drug resistance
TS-043509 — A cold-responsive nanoparticle that quickly disassembles upon ice cooling leading to intracellular burst release of a chemotherapeutic drug in seconds
Stimuli-responsive nanoparticles (NPs) hold great promise for controlling drug release inside cancer cells. An obstacle to the effectiveness of this approach to chemotherapeutic drug delivery is the rapid expulsion of the delivered drug catalyzed by efflux pumps in the cell's plasma membrane. …
  • College: College of Engineering (COE)
  • Inventors: He, Xiaoming "Shawn"; Wang, Hai
  • Licensing Officer: Norris, Francis "Frank"

Folding Transducer Array for Compact and Deployable Wave-Energy Guiding System
TS-043186 — A novel acoustic/ultrasonic wave-energy guiding system that utilizes structural topology to enhance directional and spectral sensitivities instead of phase delay, offering exceptional versatility and adaptable performance.
Although acoustic beamforming systems that are based on phase delays can be used to enhance directional and spectral sensitivities, each source or receiver must be individually controlled by appropriate phase delays to guide the acoustic energy radiation/reception sensitivities. This results in a …
  • College: College of Engineering (COE)
  • Inventors: Harne, Ryan
  • Licensing Officer: Norris, Francis "Frank"

High-strength and Corrosion Resistant Alloy for Patient-Specific Bioresorbable Bone Fixation Hardware
TS-042526 — Novel ternary and quaternary Mg-Zn-Ca-based alloys and a heat treatment process for producing bioresorbable bone fixation implants with improved mechanical and corrosion properties
Mg-Zn-Ca-based alloys are the most promising alloy system for bone implant applications mainly due to their superior biocompatibility. For fixation applications, the ideal is a material strong enough to hold while healing (2-4 months) yet being fully resorbed after the bones have healed (6-24 mont…
  • College: College of Medicine (COM)
  • Inventors: Dean, David; Elahinia, Mohammad; Ibrahim, Hamdy
  • Licensing Officer: Norris, Francis "Frank"

miRNA Biomarkers for Diagnosis and Prediction of Radiation Induced Injury
TS-041968 — A minimally invasive procedure to determine radiation toxicity in victims of nuclear events or radiation therapy patients.
The lack of a reliable radiation biodosimeter has been a major barrier to medical decision-making regarding the triage and treatment of persons - civilians, soldiers and first-time responders - who might be at risk for developing acute radiation syndromes (ARS) following nuclear events (e.g. nucle…
  • College: College of Medicine (COM)
  • Inventors: Jacob, Naduparambil "Naduparambil"
  • Licensing Officer: Norris, Francis "Frank"

Virtual image generation of immunohistochemical stained tissue sections using an artificial neural network
TS-039781 — Realistic immunohistochemical stained tissue section databases for training, certification, and machine standards.
Immunohistochemistry (IHC) is used to determine antigen distribution in a tissue and is widely used for diagnosis of cancers and other diseases. Diagnostic and research laboratories in the United States use locally devised IHC tissue slide preparation and scanning protocols to check scanner perfor…
  • College: College of Medicine (COM)
  • Inventors: Gurcan, Metin; Lozanski, Gerard; Senaras, Caglar
  • Licensing Officer: Norris, Francis "Frank"

Automated Detection of Tumor Budding in Colorectal Cancer
TS-039267 — A non-invasive and automated tumor budding image analysis system for colorectal cancer. This program can detect tumor buds in traditional H&E stained sections without the need for manual assessment.
Colorectal cancer is the third most commonly diagnosed cancer in the United States. With a survival rate of less than 65%, early detection and treatment are key factors in survival. Tumor budding, associated with higher tumor stage, lymph node metastasis, and decreased disease-free survival, has e…
  • College: College of Medicine (COM)
  • Inventors: Gurcan, Metin; Ahmad Fauzi, Mohammad Faizal; Chen, Wei "Wei"; Frankel, Wendy
  • Licensing Officer: Norris, Francis "Frank"

Design and apparatus for quantification of the mapping of the sensory areas of the brain
TS-039164 — A new tool that can quantify the sensory maps of the human brain. The tool can be used to quantify plasticity and pathology in the sensory areas of the human brain that are associated with normal and abnormal development, aging, and diseases in sensory systems. The first application of the tool, on retinotopic maps of the visual cortex, has generated excellent results.
By analyzing the stimulus­-referred fMRI responses in each voxel of an MR image, retinotopic mapping of human visual cortex can generate cortical maps of the visual space. These maps elucidate the spatial organization of the neuronal responses to visual images. Although numerous studies have b…
  • College: College of Arts & Sciences
  • Inventors: Wang, Yalin; Lu, Zhong-Lin
  • Licensing Officer: Norris, Francis "Frank"

Perivascular Drug Delivery Nanoplatform for Preventing Restenosis After Open Surgery
TS-039004 — Pericelle: a nanoparticle based perivascular drug delivery system to prevent stenosis and failure in vascular reconstruction surgeries
Imaging and re-intervention procedures, necessary to maintain open blood vessels following vascular reconstruction surgery, are expensive. For example, the cost of maintenance for an atriovenous (AV) fistula used in hemodialysis access has been estimated at near a staggering $15,000/year. In bypas…
  • College: College of Medicine (COM)
  • Inventors: Kent, K. Craig; Chen, Guojun; Gong, Shaoqin; Guo, Lianwang; Shi, Xudong
  • Licensing Officer: Norris, Francis "Frank"

Iron Oxide Composites with Low Concentration of Aliovalent Dopants As Oxygen Carrier Materials for Sustainable Redox Combustion and Gasification Reactions in Chemical Looping Reactor Systems
TS-038513 — Addition of low concentration aliovalent transition metal dopants substantially improves particle performance in chemical loopiong systems
Cyclic systems are required for energy conversion systems. In the clean energy industry, chemical looping offers promise for carbon dioxide capture from fossil energy. Transition metal oxides such as iron oxide, nickel oxide, and copper oxide have been singled out as the desired active oxygen carr…
  • College: College of Engineering (COE)
  • Inventors: Fan, Liang-Shih; Cheng, Zhuo; Chung, Cheng; Guo, Mengqing "MENGQING"; Qin, Lang
  • Licensing Officer: Norris, Francis "Frank"

Method for producing therapeutic exosomes from nanoelectroporation based cell transfection
TS-038403 — A method for producing therapeutic extracellular vesicles that contain functional mRNAs, miRNAs and shRNAs, for non-endocytic deliver of DNA for applications in cancer treatment and regenerative medicine.
Numerous cell types secrete extracellular vesicles (EVs), including exosomes and microvesicles. Exosomes are nano-vesicles (40–150 nm), and contain both coding and non-coding RNAs and their fragments, DNA fragments, proteins, and other cell related biomolecules. EVs and their biomolecule con…
  • College: College of Engineering (COE)
  • Inventors: Lee, L James; Shi, Junfeng; Yang, Zhaogang
  • Licensing Officer: Norris, Francis "Frank"

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