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A new modular format for bispecific antibody fragments
TS-068425 — Functionalization of scFvs with cyclic peptide linkers
The Need The high specificity of antibodies has been utilized to develop numerous technologies, tools and therapeutics, like ADCs and radiopharmaceuticals. Engineered antibody fragments like single-chain variable fragments (scFvs) are starting to see their way into the clinic in BiTEs and CAR T. Sc…
  • College: College of Arts & Sciences
  • Inventors: Magliery, Thomas; Do, Jamie; Han, Jeong Min "Mina"; Zhu, Ian
  • Licensing Officer: Panic, Ana

Noninvasive Rapid Radiation Exposure Assay
TS-068290 — The Need Radiation exposure poses significant health risks, including cancer and other illnesses, making it crucial for clinicians to accurately measure and assess the extent of radiation exposure. Existing methods often require invasive procedures and may not detect exposure at lower dose ranges. …
  • College: College of Arts & Sciences
  • Inventors: Schultz, Zachary; Jacob, Naduparambil; Morder, Courtney; Witte, Spencer
  • Licensing Officer: Panic, Ana

RAFT Agents for Controlled Radical Polymerization of Biofunctionalized Polymeric Materials
TS-068081 — These RAFT agents enable synthesis of novel polymer materials with enhanced biocompatibility and tailored functionality, suited for a wide range of biomedical applications.
Background The growing demand for biofunctionalized polymer materials in fields such as drug delivery and diagnostics requires precise control over polymer properties. However, current reagents for Reversible Addition Fragmentation chain Transfer (RAFT) polymerization struggle with achieving the ne…
  • College: College of Arts & Sciences
  • Inventors: Kulkarni, Anuja; Watkins, Davita
  • Licensing Officer: Panic, Ana

Precision RNA-PROTACs: Revolutionizing Therapeutic Targeting of Dysregulated Ribonucleoprotein Complexes
TS-065457 — The Need: In the realm of therapeutic development, there's a pressing need for precise targeting of dysregulated ribonucleoprotein (RNP) complexes to combat various diseases, particularly neurodegenerative disorders like ALS, Alzheimer’s, and Huntington’s diseases. Traditional metho…
  • College: College of Arts & Sciences
  • Inventors: Bong, Dennis; Liang, Yufeng; Miao, Shiqin "Shiqin"; Strong, Rebekah
  • Licensing Officer: Panic, Ana

Magnetic Nanoparticles for Cancer Cell Classification
TS-064577 — Glioblastoma (GBM) is the most common malignant brain tumor accounting for 47.7% of all brain cancers. Unfortunately, treatments are limited, and survival is poor, with approximately only 40% living past the first-year post-diagnosis and 17% in the second year. The Need Developing drugs for cance…
  • College: College of Arts & Sciences
  • Inventors: Schultz, Zachary; Rist, David; Skardal, Aleksander; Venere, Monica
  • Licensing Officer: Panic, Ana

Utilizing WT-IV-012 to improve immune checkpoint therapy in cancer treatment
TS-064262 — The Need Addressing the limitations of current melanoma therapies, there exists a critical need for innovative approaches that enhance the effectiveness of immune checkpoint therapeutics. Despite advancements in immunotherapy, a significant percentage of melanoma patients do not achieve complete re…
  • College: College of Arts & Sciences
  • Inventors: Burd, Craig; Aguilar-Valenzuela, Renan; Burd, Christin
  • Licensing Officer: Panic, Ana

Small molecules that suppress heat/pain perception
TS-064187 — The Need In the culinary and pharmaceutical realms, the need for a groundbreaking solution to modulate flavor and alleviate sensory perceptions is crucial. Businesses seek innovative ways to enhance consumer experiences by addressing pungency in foods and alleviating burn or pain sensations in phar…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Peterson, Devin; Borcherding, Joel
  • Licensing Officer: Panic, Ana

A new diagnostic assay for classic galactosemia
TS-064133 — Classic galactosemia is a genetic condition that can lead to life-threatening complications, including feeding problems, failure to thrive, liver damage, bleeding, and sepsis. If a lactose-restricted diet is provided during the first ten days of life, the neonatal symptoms quickly resolve and reduce…
  • College: College of Arts & Sciences
  • Inventors: Gopalan, Venkat; Bashian, Eleanor; Thirugnanasambantham, Pankajavalli
  • Licensing Officer: Panic, Ana

Methods and Apparatus to Improve MRI Efficiency
TS-062627 — Magnetic Resonance Imaging (“MRI”) is one of the most important modern medical imaging modalities. It has far less risk of side effects than most other imaging modalities. Generally, a high quality image requires high signal-to-noise ratio, high contrast between normal and pathological t…
  • College: College of Arts & Sciences
  • Inventors: Wang, Jinghua
  • Licensing Officer: Panic, Ana

Sensor for detecting Viruses
TS-062553 — The Need The swift and accurate diagnosis of COVID-19 and other viruses is crucial in preventing their spread. Current detection methods like PCR and antibody testing have limitations, including long run times, sample preparation, and high false negative rates. Moreover, with the rapid mutation and…
  • College: College of Arts & Sciences
  • Inventors: Schultz, Zachary; Payne, Taylor
  • Licensing Officer: Panic, Ana

Addressing the Challenges in Cancer Imaging
TS-062545 — The Need: Addressing the Challenges in Cancer Imaging Cancer continues to be a major cause of global mortality, with over 10% of all deaths attributed to this devastating disease. Despite significant advancements in cancer research, there remains a critical need to enhance current techniques for pr…
  • College: College of Arts & Sciences
  • Inventors: Magliery, Thomas; Long, Nicholas; Sullivan, Brandon
  • Licensing Officer: Panic, Ana

Addressing the Challenges in Cancer Imaging
TS-062544 — The Need: Addressing the Challenges in Cancer Imaging Cancer continues to be a major cause of global mortality, with over 10% of all deaths attributed to this devastating disease. Despite significant advancements in cancer research, there remains a critical need to enhance current techniques for pr…
  • College: College of Arts & Sciences
  • Inventors: Magliery, Thomas; Allen, Heather; Alten, Edward; Hitchcock, Charles; Long, Nicholas; Martin, Edward; Sullivan, Brandon
  • Licensing Officer: Panic, Ana

SCTaware: Empowering Health Equity through Virtual Sickle Cell Trait Education
TS-062440 — The Need: Sickle Cell Trait (SCT) affects a significant portion of the population, posing a pressing public health concern. Lack of awareness and limited access to understandable information about SCT's reproductive implications contribute to health disparities among affected individuals. In-per…
  • College: College of Arts & Sciences
  • Inventors: Chan, Peter; McCorkle, Benson; Shen, Yvette
  • Licensing Officer: Panic, Ana

Collaborative Interaction System- Wearable Technology for Collaborative Interaction for Children with Disabilities
TS-062336 — The Need: Enhancing Collaborative Interaction for Children with Disabilities Millions of children in the United States with physical or cognitive disabilities face challenges in participating fully in play and forming meaningful connections with their parents and caregivers. The lack of touch and c…
  • College: College of Arts & Sciences
  • Inventors: Swearingen, EunKyoung "Kyoung"; Kiourti, Asimina; Swearingen, Scott; Thrane, Susan
  • Licensing Officer: Panic, Ana

PERSONAL PROTECTIVE EQUIPMENT FROM ELECTROSPUN FLEXIBLE FIBER MATS
TS-062224 — The Need: Advancing Nonwoven Fibrous Webs for Personal Protective Equipment The demand for high-performance personal protective equipment (PPE) has been escalating rapidly, necessitating improved nonwoven materials that can meet stringent safety requirements. Traditional nonwoven fibrous webs lack …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Puskas, Judit
  • Licensing Officer: Panic, Ana

Novel use of deodorizing compounds as mosquito repellents
TS-062210 — The Need Insect-borne diseases, such as dengue fever, chikungunya fever, malaria, yellow fever, and Zika virus, continue to pose significant health risks worldwide. With the drawbacks of existing repellents, there is a pressing commercial need for innovative and effective compounds and compositions…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Piermarini, Peter; Marr, William Lyndon
  • Licensing Officer: Panic, Ana

Stealth liposomes with greater stability for improved drug delivery
TS-048888 — Liposome drug delivery systems play a significant role in the formulation of new therapies. These liposome-encapsulated drugs are used to treat a wide range of diseases such as cancer, influenza, and hepatitis. While endogenous liposomes are recognized by the mononuclear phagocyte system and clear…
  • College: College of Arts & Sciences
  • Inventors: Bong, Dennis
  • Licensing Officer: Panic, Ana

Protecting Against Chemical Threats: A Revolutionary Solution
TS-044619 — The Need: The threat of chemical weapons, such as sarin gas and VX, looms large in today's world. These organophosphorus (OP) nerve agents can cause rapid and devastating neurological damage, leading to paralysis, respiratory failure, and death. Current treatments, like oximes, are ineffective …
  • College: College of Arts & Sciences
  • Inventors: Hadad, Christopher; Callam, Christopher; Corrigan, Thomas; Dicken, Rachel; Dogan Ekici, Ozlem; Fitzpatrick, Keegan; Franjesevic, Andrew; McElroy, Craig; McKenney, Ryan; Muthukrishnan, Siva; Sanan, Toby; Vyas, Shubham; Yoder, Ryan; Young, Amneh "Amneh"
  • Licensing Officer: Panic, Ana

Method to improve efficiency and specificity of human tumor targeting and elimination by using a combination of split & splice protein toxins and oncolytic viruses
TS-040838 — Novel strategy to improve efficiency and specificity of tumor treatment via combinative use of a split & splice protein toxin and oncolytic virus.
In combating malignancies as complex as cancer, researchers and clinicians have created a diverse set of strategies to reduce tumor burden. Oncolytic viruses (OVs) have emerged as a promising means of treating this disease due to their potential to selectively target and effectively kill cancer ce…
  • College: College of Arts & Sciences
  • Inventors: Kudryashov, Dmitri; Cripe, Timothy; Kudryashova, Elena; Purde, Vedud
  • Licensing Officer: Panic, Ana

Paper-based Dried Blood Spheroids for Stabilization of Labile Organic Compounds Stored in Ambient Air
TS-038604 — Apparatus and methods to form three-dimensional dried blood spheroids on hydrophobic paper substrates.
Dried blood spots on paper substrates offer a facile sample collection, storage, and transportation approach for biofluids. However, variable diffusion, volcanic effects, analyte instability, and difficulty in recovering samples from paper plague this method, lowering confidence in analyte quantif…
  • College: College of Arts & Sciences
  • Inventors: Badu-Tawiah, Abraham; Damon, Deidre
  • Licensing Officer: Panic, Ana

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