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Direct Analysis of Air and Water Sensitive Material by In-Chamber Ionization Mass Spectrometry
TS-067160 — The Need Due to the unparalleled ability of Mass spectrometry (MS) to identify and quantify substances at the molecular level it is an indispensable tool in various industries, from pharmaceuticals and forensics to environmental monitoring and materials science. However, the power of MS is often hi…
  • College: College of Arts & Sciences
  • Inventors: Badu-Tawiah, Abraham; Hadad, Christopher; Lalisse, Remy; Sahraeian, Taghi; Wu, Yiying; Zheng, Jingfeng
  • Licensing Officer: Panic, Ana

Co-Axial Contained Electrospray Ionization Platform for Mass Spectrometry
TS-067158 — The Need Mass spectrometry (MS) is used across a wide range of applications for detection of various chemical analytes such as drug metabolites, pesticides, food adulterants, and natural product extracts. Recent developments have transformed MS into an all-purpose technique for in-situ and real-tim…
  • College: College of Arts & Sciences
  • Inventors: Badu-Tawiah, Abraham; Burris, Benjamin "Ben"; Grooms, Alex; Heiss, Derik; Kulyk, Dmytro
  • Licensing Officer: Panic, Ana

Advanced Mass Spectrometry Hybrid Ionization Technology for Comprehensive Molecular Analysis
TS-066752 — In today's fast-paced commercial and scientific environments, there is an increasing demand for precise and efficient analytical techniques capable of handling complex mixtures with diverse physicochemical properties. Existing ionization techniques like Electrospray Ionization (ESI) and Atmosp…
  • College: College of Arts & Sciences
  • Inventors: Badu-Tawiah, Abraham; Damale, Purva; Grooms, Alex; Kulyk, Dmytro
  • Licensing Officer: Panic, Ana

Specific Pathogen Free Turkey Eggs
TS-065846 — The Need: With the persistent threat of avian diseases, ensuring the health and safety of turkey populations is of utmost importance to the poultry industry. Traditional methods of disease prevention have limitations, necessitating a technology that can reliably produce Specific Pathogen Free (SPF) …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Saif, Mo
  • Licensing Officer: Panic, Ana

SUMO^RIT Tag: Revolutionizing Downstream Gene Translation
TS-065844 — The Need: In modern biotechnology and pharmaceutical industries, precise control over gene expression is paramount. However, conventional translation processes often lead to inefficiencies, resulting in reduced yields and compromised protein function. Meeting the demand for enhanced gene expression …
  • College: College of Arts & Sciences
  • Inventors: Law, Jamison
  • Licensing Officer: Panic, Ana

3D printed hemlock twig key tag showing feeding locations of hemlock woolly adelgid (HWA) and elongate hemlock scale (EHS)
TS-065837 — The Need: In the fight against invasive species threatening our forests, rapid and accurate identification is paramount. Traditional methods for monitoring pests like the Hemlock Woolly Adelgid (HWA) and Elongate Hemlock Scale (EHS) can be time-consuming and imprecise, leading to delayed responses a…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Basnagala, Suranga; Perry, Kayla
  • Licensing Officer: Panic, Ana

3D printed Elm leaves to show Elm Zigzag Sawfly (Aproceros leucopoda) larval feeding damage.
TS-065836 — The Need: In today's agricultural landscape, precise identification and monitoring of pest damage are paramount for maintaining crop health and maximizing yields. Traditional methods often fall short in accurately assessing and addressing the impact of pests like the Elm Zigzag Sawfly (Aproceros…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Basnagala, Suranga; Perry, Kayla
  • Licensing Officer: Panic, Ana

Precision RNA-PROTACs: Revolutionizing Therapeutic Targeting of Dysregulated Ribonucleoprotein Complexes
TS-065457 — The Need: In the realm of therapeutic development, there's a pressing need for precise targeting of dysregulated ribonucleoprotein (RNP) complexes to combat various diseases, particularly neurodegenerative disorders like ALS, Alzheimer’s, and Huntington’s diseases. Traditional metho…
  • College: College of Arts & Sciences
  • Inventors: Bong, Dennis; Liang, Yufeng; Miao, Shiqin "Shiqin"; Strong, Rebekah
  • Licensing Officer: Panic, Ana

Revolutionizing RNA-Protein Interaction Mapping: Precision Proximity Labeling Technology
TS-065456 — The Need In modern biological research, there is a pressing demand for technologies that enable precise mapping of RNA-protein interactions within Ribonucleoprotein (RNP) complexes. Traditional methods often lack the capability to pinpoint these interactions at the level of secondary structure moti…
  • College: College of Arts & Sciences
  • Inventors: Bong, Dennis; Liang, Yufeng; Miao, Shiqin "Shiqin"
  • Licensing Officer: Panic, Ana

Advancing RNA Detection with Innovative Peptide-Based Fluorescent Probes
TS-065455 — The Need: In modern biotechnology and biomedical research, there is an escalating demand for efficient tools that can accurately detect and analyze specific RNA sequences. The ability to precisely target and identify RNA molecules, particularly U-rich sequences, is crucial for various applications s…
  • College: College of Arts & Sciences
  • Inventors: Bong, Dennis; DeSantis, Christopher; Gopalan, Venkat; Liang, Yufeng; Mao, Jie; Marathe, Ila; Miao, Shiqin "Shiqin"
  • Licensing Officer: Panic, Ana

Revolutionizing Pharmaceutical Synthesis: Advancements in Metal-Catalyzed Coupling Technology
TS-064824 — The Need In the pharmaceutical industry, the synthesis of complex organic substrates is crucial for the development of life-saving medications. However, traditional metal-catalyzed coupling reactions often face significant challenges when applied to these complex substrates, leading to high failure…
  • College: College of Arts & Sciences
  • Inventors: Sevov, Christo; Dinh, Long; Hamby, Taylor; Starbuck, Hunter
  • Licensing Officer: Panic, Ana

Magnetic Nanoparticles for Cancer Cell Classification
TS-064577 — Glioblastoma (GBM) is the most common malignant brain tumor accounting for 47.7% of all brain cancers. Unfortunately, treatments are limited, and survival is poor, with approximately only 40% living past the first-year post-diagnosis and 17% in the second year. The Need Developing drugs for cance…
  • College: College of Arts & Sciences
  • Inventors: Schultz, Zachary; Rist, David; Skardal, Aleksander; Venere, Monica
  • Licensing Officer: Panic, Ana

Fluorescent probes for intracellular RNA tracking
TS-062554 — The Need: Intracellular RNA fluorescence labeling is a crucial technique for studying cellular processes and understanding gene expression. However, the conventional MS2 labeling method using protein fusion labels can have drawbacks, such as increased mass, potential steric accessibility issues, and…
  • College: College of Arts & Sciences
  • Inventors: Bong, Dennis; Liang, Yufeng
  • Licensing Officer: Panic, Ana

Next-Generation Contained Mass Spectrometry capable of On-line Solid-Phase Extraction and Atmospheric Pressure Chemical Ionization of Nonvolatile Solid and Liquid Complex Samples
TS-062340 — The Need There is a commercial need for an advanced ionization and analysis technology that can effectively and rapidly detect and analyze organic compounds, including both polar and non-polar ones, in various matrices. The current challenges in existing ambient mass spectrometry (MS) methods inclu…
  • College: College of Arts & Sciences
  • Inventors: Badu-Tawiah, Abraham; Kulyk, Dmytro
  • Licensing Officer: Panic, Ana

Development of Thread Spray Ambient Mass Spectrometry
TS-062337 — The Need: The healthcare industry is witnessing rapid changes, and the establishment of biobanks to collect and store biological specimens has become crucial for facilitating research and healthcare advancements. However, current microsampling techniques face challenges such as handling small sample…
  • College: College of Arts & Sciences
  • Inventors: Badu-Tawiah, Abraham; Jackson, Sierra; Swiner, Devin
  • Licensing Officer: Panic, Ana

Genetic Method for Generating Continuous Cell Lines in Drosophila.
TS-062331 — The Need: Advancing Drosophila Cell Culture for Biological Research In biological research, the analysis of cells in culture has been pivotal in advancing our understanding of various biological processes. However, the underdeveloped state of Drosophila cell culture has presented a challenge, as th…
  • College: College of Arts & Sciences
  • Inventors: Simcox, Amanda; Dequeant, Mary-Lee; Perrimon, Norbert
  • Licensing Officer: Panic, Ana

Method and Apparatus for Contained-Electrospray for Use in Mass Spectrometry and Droplet Reactions
TS-062326 — The Need: In today's analytical landscape, there is a pressing demand for improved sensitivity in electrospray ionization (ESI) to accurately quantify diverse analytes within complex mixtures. However, this task is often hindered by varying ionization responses among different compounds, includ…
  • College: College of Arts & Sciences
  • Inventors: Badu-Tawiah, Abraham; Kulyk, Dmytro
  • Licensing Officer: Panic, Ana

Propionibacterium acidipropionici Knockout Mutant for Propionic Acid Fermentation
TS-062323 — The Need: In today's industrial landscape, the demand for sustainable and cost-effective bio-based chemicals continues to rise. Propionic acid, a valuable building block in various industries, including food, pharmaceuticals, and plastics, is no exception. However, conventional production method…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"
  • Licensing Officer: Panic, Ana

Programmable Magnetic Platform for Biomolecular Sorting
TS-062300 — The Need: In modern research and diagnostics, there is a growing demand for an advanced technology that can efficiently isolate, manipulate, and sort individual micro- or nano-scale biomolecules such as cells, viruses, DNA, proteins, and peptides. Traditional methods have proven to be slow, power-in…
  • College: College of Arts & Sciences
  • Inventors: Sooryakumar, Ratnasingham; Chalmers, Jeffrey; Henighan, Thomas; Vieira, Gregory
  • Licensing Officer: Panic, Ana

Paper-based Dried Blood Spheroids for Stabilization of Labile Organic Compounds Stored in Ambient Air
TS-038604 — Apparatus and methods to form three-dimensional dried blood spheroids on hydrophobic paper substrates.
Dried blood spots on paper substrates offer a facile sample collection, storage, and transportation approach for biofluids. However, variable diffusion, volcanic effects, analyte instability, and difficulty in recovering samples from paper plague this method, lowering confidence in analyte quantif…
  • College: College of Arts & Sciences
  • Inventors: Badu-Tawiah, Abraham; Damon, Deidre
  • Licensing Officer: Panic, Ana

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