Novel HIV Targeting Strategy for Next‑Generation Antivirals
TS-074218 — This HIV-focused technology introduces a novel strategy for engaging conserved viral biology that is not directly addressed by existing antiretroviral classes. By expanding the range of actionable HIV mechanisms, the approach creates new opportunities for therapeutic discovery, combination strategies, and next‑generation intervention concepts. The technology is designed to complement current HIV treatment paradigms while supporting diversification of long‑term antiviral pipelines.
Technology Overview
This HIV-focused technology introduces a novel strategy for engaging conserved viral biology that is not directly addressed by existing antiretroviral classes. By expanding the range of actionable HIV mechanisms, the approach creates new opportunities for therapeutic discove…
- College: College of Arts and Sciences (COAAS)
- Inventors: Musier-Forsyth, Karin; Kelley, Elise; Nielsen, Andrew
- Licensing Officer: Panic, Ana
Breakthrough In Delivery: Expanding Access to Intracellular Targets for Next-Generation Therapies
TS-072004 — Empower your pipeline with a versatile platform for efficient, customizable biomolecule transport.
Overview
Intracellular delivery remains a persistent challenge in drug delivery, gene editing, and biotechnology. Pharmaceutical and biotech companies lose valuable opportunities when promising drugs and biologics cannot reach their intended targets inside cells, limiting product effectiveness and m…
- College: College of Arts and Sciences (COAAS)
- Inventors: Bong, Dennis
- Licensing Officer: Panic, Ana
Smart Blueberry Extract: The Modern Natural Health Solution for Inflammation Relief and Wellness
TS-071830 — Unlocking plant-powered solutions to deliver effective inflammation relief and enhance disease outcomes.
Overview
Chronic inflammation driven by elevated interleukin-11 (IL-11) is a critical underlying cause of tissue scarring and cancer, worsening the disease outcomes over time. Current anti-inflammatory options fall short, offering limited control over IL-11 and failing to stop its persistent buildu…
- College: College of Food, Agricultural, and Environmental Sciences (CFAES)
- Inventors: Giusti, M. Monica; Prasher, Harmeen; Sellers, Patrick; Ziouzenkova, Ouliana
- Licensing Officer: Panic, Ana
A new modular format for bispecific antibody fragments
TS-068425 — Functionalization of scFvs with cyclic peptide linkers
The Need
The high specificity of antibodies has been utilized to develop numerous technologies, tools and therapeutics, like ADCs and radiopharmaceuticals. Engineered antibody fragments like single-chain variable fragments (scFvs) are starting to see their way into the clinic in BiTEs and CAR T. Sc…
- College: College of Arts and Sciences (COAAS)
- Inventors: Magliery, Thomas; Do, Jamie; Han, Jeong Min "Mina"; Zhu, Ian
- Licensing Officer: Panic, Ana
Precision RNA-PROTACs: Revolutionizing Therapeutic Targeting of Dysregulated Ribonucleoprotein Complexes
TS-065457 — The Need:
In the realm of therapeutic development, there's a pressing need for precise targeting of dysregulated ribonucleoprotein (RNP) complexes to combat various diseases, particularly neurodegenerative disorders like ALS, Alzheimer’s, and Huntington’s diseases. Traditional metho…
- College: College of Arts and Sciences (COAAS)
- Inventors: Bong, Dennis; Liang, Yufeng; Miao, Shiqin "Shiqin"; Strong, Rebekah
- Licensing Officer: Panic, Ana
Playing with Fire; flavor modulators to control spicy food experiences
TS-064187 — The Need
Spicy foods can be polarizing as too much can make food simply inedible for some while others may still want it hotter. Spice tolerance is also highly subjective making it hard to adjust spice levels appropriately - what could be a very spice dish to some might not even register as spciy t…
- College: College of Food, Agricultural, and Environmental Sciences (CFAES)
- Inventors: Peterson, Devin; Borcherding, Joel
- Licensing Officer: Panic, Ana
Underwater Zooplankton Enhancing Light Array (UZELA); A Novel Device for Stimulating Nutritional Therapy in Corals
TS-062571 —
The Need
Coral reefs are declining at an alarming rate. When temperatures increase by as little as 1-2 °C above their normal thermal maximum for as little as ten days, corals become stressed, lose their endosymbiotic algae, and turn white – hence the term bleaching. When bleached, corals…
- College: College of Arts and Sciences (COAAS)
- Inventors: Grottoli, Andrea; Dixon, Shannon; Hulver, Ann Marie; Jackson, Eric; Shea, Ryan; Steck, James
- Licensing Officer: Panic, Ana
Addressing the Challenges in Cancer Imaging
TS-062545 — The Need: Addressing the Challenges in Cancer Imaging
Cancer continues to be a major cause of global mortality, with over 10% of all deaths attributed to this devastating disease. Despite significant advancements in cancer research, there remains a critical need to enhance current techniques for pr…
- College: College of Arts and Sciences (COAAS)
- Inventors: Magliery, Thomas; Long, Nicholas; Sullivan, Brandon
- Licensing Officer: Panic, Ana
Addressing the Challenges in Cancer Imaging
TS-062544 — The Need: Addressing the Challenges in Cancer Imaging
Cancer continues to be a major cause of global mortality, with over 10% of all deaths attributed to this devastating disease. Despite significant advancements in cancer research, there remains a critical need to enhance current techniques for pr…
- College: College of Arts and Sciences (COAAS)
- Inventors: Magliery, Thomas; Allen, Heather; Alten, Edward; Hitchcock, Charles; Long, Nicholas; Martin, Edward; Sullivan, Brandon
- Licensing Officer: Panic, Ana
Probiotic for Enhanced Mood and Gut Health
TS-062355 — The Need
In today's fast-paced and demanding world, the need for innovative solutions that enhance mental well-being and cognitive performance has never been greater. Recent scientific discoveries have highlighted the crucial role of the gut-brain connection in influencing human behavior and br…
- College: College of Food, Agricultural, and Environmental Sciences (CFAES)
- Inventors: Jacobi, Sheila; Brown, Rebecca; Delaney, Erica; Jimenez-Flores, Rafael; Miller, Celeste
- Licensing Officer: Panic, Ana
Protecting Against Chemical Threats: A Revolutionary Solution
TS-044619 — The Need:
The threat of chemical weapons, such as sarin gas and VX, looms large in today's world. These organophosphorus (OP) nerve agents can cause rapid and devastating neurological damage, leading to paralysis, respiratory failure, and death. Current treatments, like oximes, are ineffective …
- College: College of Arts and Sciences (COAAS)
- Inventors: Hadad, Christopher; Callam, Christopher; Corrigan, Thomas; Dicken, Rachel; Dogan Ekici, Ozlem; Fitzpatrick, Keegan; Franjesevic, Andrew; McElroy, Craig; McKenney, Ryan; Muthukrishnan, Siva; Sanan, Toby; Vyas, Shubham; Yoder, Ryan; Young, Amneh "Amneh"
- Licensing Officer: Panic, Ana
Immunomodulating agents engineered from Notch receptor ligand extracellular domains
TS-036760 — Immunomodulating agents have been engineered from Notch receptor ligand extracelluar domains. These are useful for stimulating the immune system.
The Notch signaling pathway is important in immune cell differentiation and maturation. As a result, it has been shown that Notch receptor signaling can promote or suppress adaptive immune responses depending on the particular ligands and receptors involved. A set of native protein-inspired biolog…
- College: College of Arts and Sciences (COAAS)
- Inventors: Magliery, Thomas; Carbone, David; Dikov, Mikhail; Long, Nicholas; Sullivan, Brandon; Tchekneva, Elena
- Licensing Officer: Panic, Ana
Method to Synthesize Ceratamine A and B and Analogs Thereof
TS-030264 — A chemical process to produce ceratamine A and B.
The natural products ceratamines A and B were isolated from a marine sponge in minute quantities and shown to have potent anti-tumor activity. Due to the insufficient sample size and subsequent lack of availability of the producing sponge, evaluation was incomplete. Thus, the clinical potential ne…
- College: College of Arts and Sciences (COAAS)
- Inventors: Coleman, Robert "Rob"; Campbell, Erica
- Licensing Officer: Panic, Ana
Self-Assembly of Therapeutic-Agent Nanostructures
TS-014812 — An improved delivery mechanism has been developed for hydrophobic drugs such as camptothecin which will increase chemotherapeutic efficacy.
Many cancer therapeutics exhibit extremely toxic side effects or have limited efficacy due to low bio-availability. Existing drug delivery technologies can add excessive mass to the therapeutic, grossly expanding the dosage necessary for response. Camptothecin (CPT) is a naturally occurring compou…
- College: College of Arts and Sciences (COAAS)
- Inventors: Parquette, Jonathan; Grinstaff, Mark; Kaplan, Jonah; Kim, Se Hye
- Licensing Officer: Panic, Ana