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Modulation of Mismatch Repair and Genomic Stability by miR-155
TS-062322 — The Need The field of molecular biology faces a critical commercial need in the effective diagnosis, treatment, and prevention of cancer-related disorders associated with mismatch repair (MMR) dysfunction. Diseases such as Lynch Syndrome (LS) and hereditary non-polyposis colorectal cancer (HNPCC), …
  • College: College of Medicine (COM)
  • Inventors: Croce, Carlo; Valeri, Nicola
  • Licensing Officer: Willson, Christopher

Diagnosis of Chemoresistant Ovarian Cancer.
TS-062306 — The Need Ovarian cancer is a significant health concern, being the leading cause of gynecological cancer-related deaths in the developed world. Current treatments, such as platinum-based chemotherapy, have limited success due to issues like late-stage diagnosis and chemoresistance. Identifying mole…
  • College: College of Medicine (COM)
  • Inventors: Croce, Carlo; Vecchione, Andrea
  • Licensing Officer: Willson, Christopher

Microrna-21, Mismatch Repair, and Colorectal Cancer
TS-062305 — The Need: Colorectal cancer (CRC) is a significant health concern, with a high incidence rate and limited treatment options, particularly regarding resistance to standard chemotherapy like 5-fluorouracil (5-FU). The management of CRC patients is complicated by the frequent occurrence of primary or a…
  • College: College of Medicine (COM)
  • Inventors: Croce, Carlo; Valeri, Nicola
  • Licensing Officer: Willson, Christopher

Advancing Cancer-Related Technology for Better Prognosis and Treatment
TS-062303 — The Need: Cancer continues to be a significant global health challenge, with conditions like non-small cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC) often diagnosed at advanced stages, resulting in poor prognoses. Existing treatment methods, such as TRAIL-based therapy, face obstacle…
  • College: College of Medicine (COM)
  • Inventors: Croce, Carlo
  • Licensing Officer: Willson, Christopher

MicroRNA signatures in human ovarian cancer
TS-062298 — The Need: Ovarian cancer remains a significant challenge in the field of medicine, with late-stage diagnosis and limited effective treatments contributing to high mortality rates. The need for improved diagnostic tools and targeted therapies is evident to address this aggressive disease. Convention…
  • College: College of Medicine (COM)
  • Inventors: Croce, Carlo
  • Licensing Officer: Willson, Christopher

Composition and Methods for Lung Cancer Diagnosis and Treatment
TS-062296 — The Need: Advancing Lung Cancer Detection and Treatment Lung cancer continues to be a global health concern, accounting for the highest number of cancer-related deaths worldwide. In the United States, it is the leading cause of cancer mortality for both men and women, with a disheartening five-year…
  • College: College of Medicine (COM)
  • Inventors: Croce, Carlo; Calin, George
  • Licensing Officer: Willson, Christopher

Composition and Methods for Breast Cancer Diagnosis and Treatment
TS-062295 — The Need: Breast cancer continues to be a significant health challenge, affecting a large number of women worldwide and remaining the second leading cause of cancer-related deaths among women in the United States. Despite advancements in detection and treatment, there is no universally successful m…
  • College: College of Medicine (COM)
  • Inventors: Croce, Carlo; Calin, George
  • Licensing Officer: Willson, Christopher

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